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Vernon Olson
No full textPhotograph of Vernon Olson standing in front of a grass hut in the Fijian heat. Title taken from photographer\u27s original album.https://commons.und.edu/infantry-photos/1143/thumbnail.jp
Fijian Police
No full textFijian Police walk along the road away from the camera. Title taken from photographer\u27s original album.https://commons.und.edu/infantry-photos/1141/thumbnail.jp
Social Experiences of Individuals with Autism in Adolescence and Adulthood: A literature review
Get PDFThis literature review examines social experiences of individuals with Autism Spectrum Disorder (ASD) during adolescence and adulthood, addressing a critical knowledge gap regarding developmental trajectories and support needs across the lifespan. Despite increased ASD awareness, individuals face persistent social challenges, with research showing concerning rates of isolation. The purpose of this review is to understand how sensory processing differences and atypical gaze behaviors contribute to social outcomes in ASD. As such, three key questions were asked: How do social participation patterns change from adolescence to adulthood? What sensory-based subtypes exist within ASD? How do different gaze behavior patterns relate to social functioning? Through analysis of recent empirical studies, the research found that many individuals with ASD experience limited social engagement throughout development, with community participation decreasing during the transition to adulthood. Distinct sensory subtypes were identified, including groups characterized by neural hyperresponsivity that correlates with everyday sensory difficulties. Both hyperarousal/avoidance and hypoarousal/indifference patterns of gaze behavior were observed in different subgroups. Social outcomes were predicted by individual characteristics (communication abilities, cognitive skills) and environmental factors (case management, socioeconomic resources). Future research should explore longitudinal trajectories and develop targeted interventions based on sensory profiles to better address social challenges across the diverse autism spectrum.https://commons.und.edu/as-showcase/1021/thumbnail.jp
Hairspray
No full textCast of Hairsprayhttps://commons.und.edu/performing-arts-photos/1182/thumbnail.jp
Grease
No full textCast and crew of Greasehttps://commons.und.edu/performing-arts-photos/1181/thumbnail.jp
Effects of NSAIDs on Bone Healing Time in Orthopedic Patients
Get PDFUse of NSAIDs in adults recovering from orthopedic injury or surgery has been found to be largely inconclusive when it comes to determining significance in delay of bone healing. The purpose of this review is to determine whether use of NSAIDs is detrimental to bone healing after orthopedic injury or surgery. A literature review was performed using electronic databases PubMed and SportsDiscus from May to July of 2024. There were fifteen studies that met final inclusion criteria. Research overwhelmingly acknowledged that selective COX-2 inhibitors are not recommended in a post injury or post operative state. However, when it comes to nonselective COX inhibitors, there is no definitive answer. Future research should focus on larger sample sizes, more randomized controlled trials, use of more in vivo/ in vitro study models and effects of specific NSAIDs. Investigations should also include all ages, genders, and races. The focus of initial research should be placed on otherwise healthy individuals with no known medical conditions. Subsequent studies should compare initial outcomes against individuals with the most common comorbidities and continue to grow the population outward
Efficacy of Stem Cell Therapy Versus Standard Drug Therapy in Adults with Heart Failure
Get PDFMyocardial infarction (MI) or other damage to the heart tissue may result in ischemia, and because cardiomyocytes have limited regenerative capacity, this often leads to the development of heart failure (HF). Typical symptoms of HF include dyspnea, edema, cough, fatigue, and chest pain, which arises from fluid overload and congestion. Current medical treatments focus on alleviating these symptoms through loop diuretics, which reduce fluid accumulation but do not treat the underlying ischemic damage. Recent studies have shifted focus towards stem cell therapy, which have shown potential to differentiate into cardiomyocytes and regenerate ischemic heart tissue. A comprehensive search of databases resulted in eight total articles that met inclusion criteria. This literature review explores the current standard drug therapy, the efficacy of stem cell therapy, and the combination of drug therapy and stem cell therapy in the treatment of heart failure. Despite these promising findings, further research is necessary to establish stem cell-based therapies as a viable treatment option for HF
Get In The Zone: Utilizing A Food Skills Survey To Assess The Education Needs Of A Blue Zones Project Community
Get PDFUnder-resourced communities often demonstrate little to basic knowledge and skills regarding food and nutrition-related practices, such as cooking and meal planning, nutrition label reading, and gardening. This can be attributed to various factors such as education level, socioeconomic status, available education programs, and overall interest in these topics. Limited research is available discussing the current knowledge, skills, and interests of nutrition topics and healthy eating patterns within Blue Zones Project (BZP) communities. To explore this gap in the literature, a cross-sectional design was implemented via a food skills survey completed by the residents of a modest-sized college town and site of a BZP in the upper Midwest. The University of North Dakota collaborated with the BZP to develop and distribute the food skills survey. Survey links and QR codes were distributed in person, online, and mailed on a postcard. Responses were recorded over six weeks and analyzed to assess knowledge, skills, and interest in expanding these in the areas of meal preparation, nutrition knowledge, and gardening. Analysis from 345 surveys will help to determine education opportunities within the community. Participants indicate some level of interest in increasing their cooking and meal planning skills, and time, interest, and cost as the main barriers to cooking and meal planning. Participants also indicate interest in increasing their gardening skills and identify knowledge, skills, and space as their main barriers to gardening at home
Cisplatin-Induced Nephrotoxicity And Adaptive Responses In Renal Progenitor Cells: Molecular Insights From Transcriptomic And Proteomic Analyses
Get PDFCisplatin is a widely used chemotherapeutic agent known for its efficacy against various solid tumors, but its clinical utility is limited by dose-dependent nephrotoxicity. The renal proximal tubule, particularly its epithelial cell population, is highly susceptible to cisplatin-induced injury due to its role in solute transport and high metabolic activity. Recent advances suggest that renal progenitor cells play a key role in epithelial repair following nephrotoxic injury; however, the molecular mechanisms underlying their response to cisplatin remain poorly understood.This study investigates the impact of both acute and chronic cisplatin exposure on immortalized human renal progenitor cells (HRTPT, CD24⁺/CD133⁺) using a combination of transcriptomic (RNA sequencing) and proteomic (TMT-labeled mass spectrometry) approaches. Morphological changes and platinum accumulation were evaluated using microscopy and ICP-MS, respectively. RNA-seq data revealed progressive transcriptional reprogramming across passages, marked by the upregulation of DNA damage response, oxidative stress, and apoptosis pathways, alongside suppression of metabolic and transport-related genes. Proteomic analyses supported these findings, highlighting alterations in mitochondrial function and inflammatory signaling. Notably, partial discordance between transcript and protein levels suggested possible post-transcriptional regulation during cisplatin adaptation. The results demonstrate that HRTPT cells exhibit adaptive molecular responses to cisplatin-induced stress, including changes in gene expression, protein regulation, and cellular phenotype. These findings enhance our understanding of renal progenitor cell-mediated repair mechanisms and offer potential targets for therapeutic intervention to mitigate cisplatin nephrotoxicity. This study also validates HRTPT cells as a physiologically relevant in vitro model for studying nephrotoxic injury and regeneration in the human kidney
Thermally Induced Evolution Of The Cement Microannulus In Co2 Injection Wells
No full textEnsuring wellbore integrity during CO2 injection is a critical challenge in Carbon Capture and Storage (CCS), as failures at the casing-cement and cement-formation interfaces can create potential leakage pathways. This dissertation presents a multi-scale, physics-based investigation into well integrity risks, integrating finite element analysis (FEA), thermal-mechanical-poroelastic modeling, and transient stress analysis to evaluate cement sheath stability, fracture-driven stress localization, and microannulus formation under various CCS conditions.
A key novelty of this research is the development of a fully coupled thermal-mechanical-poroelastic FEA framework using COMSOL Multiphysics, a renowned industry-standard software for multiphysics simulations. This model enables a dynamic, time-dependent assessment of stress evolution during different CO2 injection phases, improving upon traditional studies that focus solely on simplified steady-state models distributions. The results indicate that thermal contraction from low-temperature CO2 injection amplifies localized stress concentrations, increasing the risk of cement debonding, radial cracking, and microannulus formation at cement interfaces. Compared to traditional elasticity-based methods, the Drucker-Prager plasticity model provides a more realistic representation of material behavior. By capturing nonlinear deformation effects, this approach allows for a more accurate assessment of cement and formation stability. Additionally, high-resolution stress mapping identifies interface-specific failure risks, enhancing risk evaluation for caprock integrity and long-term CO2 storage.
This dissertation also introduces a novel approach to wellbore integrity assessment in fractured reservoirs, incorporating thermal, mechanical, and chemical interactions to evaluate CO2 injection effects under more realistic conditions. Unlike traditional models that assume homogeneous formations, this study quantifies how fracture networks influence stress redistribution, revealing that fractures increase localized failure risks and alter stress paths near the cement sheath. Furthermore, CO2 interactions with residual fluids (oil/water) cause acid-induced cement degradation, particularly at the cement-casing and cement-formation interfaces. The study confirms that fracture-concentrated acidic fluid pathways accelerate cement weakening, emphasizing the need for fracture-aware well integrity strategies for CCS. In comparison with conventional models, COMSOL Multiphysics provided a more accurate representation of fracture-driven stress changes.
A key contribution of this work is the development of a microannulus evolution model, which improves upon traditional resistor-based temperature models by employing a finite-difference method (FDM) for transient thermal behavior. The approach captures more accurately thermal stress cycles and their effects on wellbore integrity than standard analytical models, which cannot account for temperature fluctuations before and after shut-in. The improved model provides a robust framework for evaluating the integrity of CCS wells in varying thermal conditions.
Beyond active CO2 injection wells, this dissertation also examines well integrity risks in abandoned wells, where aging cement sheaths and mechanical degradation increase the likelihood of CO2 migration. By analyzing casing expansion, cement shrinkage, and zonal isolation failures, this study provides quantitative insights into long-term well integrity management and proposes enhanced cement design strategies to reduce long-term leakage risks.
By bridging reservoir-scale stress distribution with localized failure mechanisms, this dissertation advances CO2 well integrity assessment, offering: Quantitative guidelines for cement optimization and failure mitigation More realistic predictions of CO2-induced stress changes in fractured reservoirs A refined understanding of transient thermal effects on microannulus formation Improved risk assessment frameworks for active and abandoned CCS wells Practical recommendations for well integrity regulations and long-term CO2 storage safety
The findings contribute to safer long-term CO2 storage, enhance predictive failure models, and support the development of advanced well integrity management strategies for carbon storage and enhanced oil recovery (EOR) applications