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Moderate Exercise and Tirzepatide versus Tirzepatide Alone for Long-Term Weight Loss Maintenance
Background: Glucagon-like peptide-1 (GLP-1) receptor agonist (RA) drugs have been transformative when managing obesity in the clinical setting. Though these medications are effective for weight loss, questions regarding their efficacy for long-term weight loss or maintenance remain unanswered.
Purpose: The purpose of this scoping review was to answer the following clinical question: Can overweight or obese patients (P) who use tirzepatide without exercise (I) as compared to those incorporating 150 minutes a week of moderate aerobic exercise (C) sustain a ≥5% weight loss (O) one-year post-treatment (T)?
Methods: Five electronic article databases were searched to locate articles related to the PICOT question. Articles, including those that utilized primary studies and focused on weight loss, were evaluated. Across all article searches, 245 abstracts were retained, yielding 15 articles for use in this review.
Results: The results do not provide a definitive answer to the PICOT question. Although there is evidence that GLP-1 medications can be used to maintain weight, and that the use of a GLP-1 medication with exercise does accelerate weight loss, it is not possible to state that tirzepatide is the best medication or that aerobic exercise is the only method for weight loss.
Implications: Patients should be encouraged to exercise when prescribed a GLP-1. Exercise should be undertaken using national guidelines: 150+ minutes per week of moderate intensity exercise. The GLP-1 medication and the type of exercise used should be based on patient preferences. Additional clinical research into the topic is needed to ensure that a GLP-1 medication alone can sustain weight loss at one year
Jingle Dress
A leather jingle dress with a medicine wheel painted on the center of the chest, depictions of animal tracks and plants painted along the middle, a red collar, and tassels featuring beads and jingles are tied all the way around.
Featured in the exhibition, Plain of Stars: An exhibition to uplift, acknowledge, and celebrate Indigenous students.https://commons.und.edu/native-art/1132/thumbnail.jp
A Few Bombers Coming In
Though they\u27re difficult to see, there are a few bombers in the distance returning. Title taken from photographer\u27s original album.https://commons.und.edu/infantry-photos/1097/thumbnail.jp
Exploring the Impact of Maternal Mental Health/Psychological Interventions
Examining how a mother\u27s mental health—e.g., postnatal depression, anxiety, and stress—affects a mother\u27s physical health as well as infant development and looking at how psychological therapies for mothers could help outcomes for both mothers and children
A Bit of Poker
A circle of unidentified men play a round of poker. Title taken from photographer\u27s original album.https://commons.und.edu/infantry-photos/1134/thumbnail.jp
Sisters of the Holy Rock
Cast of Sisters of the Holy Rockhttps://commons.und.edu/performing-arts-photos/1194/thumbnail.jp
RENT
Cast of RENT - Constantine Maroulishttps://commons.und.edu/performing-arts-photos/1190/thumbnail.jp