Indonesian Journal of Obstetrics and Gynecology (INAJOG)
Not a member yet
904 research outputs found
Sort by
Classic Antiphospholipid and Antiphosphatidylserine Antibody Profile in Suspected Antiphospholipid Antibody Syndrome Patient
Get PDFObjective: To compare the classic examination results of antiphospholipid
(aPS) and antiphospatidylserine (aPL) antibody profile to
establish the diagnosis from suspected antiphospholipid antibody
syndrome (APS) patient in order to state the subsequent treatment
strategies.
Method: This descriptive cross-sectional study design was conducted
at outpatient clinics of Dr. Cipto Mangunkusumo Hospital
(RSCM) from January to December 2015. The laboratory test was
held in Clinical Pathology Laboratory RSCM/Faculty of Medicine
Universitas Indonesia (FKUI) and in corporation with Prodia laboratory.
Result: All of normal patients did not have positive result in any
laboratory examination (Lupus Anti-coagulant (LA), anticardiolipin
(aCL), anti-?2 glycoprotein I (anti-?2GPI), and aPS). In patient suspected
APS, 11 (37.1%) patients had positive aCL, 7 (25.9%) patients
had positive anti-?2GPI, and 11 (37.1%) patients had positive
aPS. The most positive cross laboratory examination was between
aCL and aPS (25.9%). In this study, we found the most positive test
result was aCL and aPS (62.9%). From this study, suspected APS patient
who had negative result in classic laboratory examination, but
showing the positive result in aPS was in 5 (18.5%) patients.
Conclusion: All normal pregnant patients do not have any positive
classic examination and aPS. Meanwhile, in patients with suspected
APS, less than 20% patients show positive result of aPS with negative
result in classic laboratory examination.
Keywords: antiphospatidylserine, antiphospolipid syndrom
Postradical Hysterectomy Survival Rate in Early Stage Cervical Cancer Patients
Get PDFObjective: Determining the survival rate of early stage cervical cancer
patients after radical hysterectomy.
Method: A retrospective cohort study was conducted on 24 earlystage
cervical cancer patients who had performed radical hysterectomy
in Prof. dr. R.D. Kandou Hospital Manado during the period
between January 2008 and December 2010. We used Kaplan-Meier
methods to observe the survival rate.
Result: The mean age of patients in this study was 47.8 (33-63)
years old with a median of 45 years old. The largest proportion was
less than 50 years old (66.7%) and stage IIA cervical cancer (66.7%)
as the severity of cancer. Most histopathology type was the squamous
cell carcinoma (50.0%). About 70.8% patients did not have
lymph nodes metastasis and 62.5% patients did not receive adjuvant
therapy. This study revealed that 1-year, 2-year, 3-year, 4-year, and
5-year survival rate were 100.0%, 100.0%, 95.8%, 83.0%, 70.8%;
respectively.
Conclusion: The survival rate of early stage cervical cancer afte[Indones J Obstet Gynecol 2016; 4-3: 164-169]
Keywords: cervical cancer, radical hysterectomy, survival rat
Theurapeutic Response of Neoadjuvant Chemotherapy between Platinum and Ifosfamide Combination and Platinum, Vincristine and Bleomycin Combination in Cervical Carcinoma Stage IB2
Get PDFObjective: To evaluate the theurapeutic response and acute toxicity
of neoadjuvant chemotherapy between the combination of Platinum
and Ifosfamide, and the combination of Platinum, Vincristine and
Bleomycin in Cervical Carcinoma Stage IB2 and then continued with
radical hysterectomy and pelvic lymphadenectomy.
Method: Thirteen samples received neoadjuvant chemotherapy of
Platinum and Ifosfamide and 17 samples received neoadjuvant chemotherapy
of Platinum, Vincristine and Bleomycin, after receiving
the neoadjuvant chemotherapy, clinically complete response samples
underwent radical hysterectomy and pelvic lymphadenectomy
(PI VS PVB = 3 VS 1). Histopathology examination was performed to
evaluate the presence of malignant viable cells at the cervix, pelvic
lymph node metastasis and parametrium metastasis. Acute toxicity
evaluation was performed based on gastrointestinal, genitourinarius
and hematology sign and symptom.
Result: Theurapeutic response of PI is 1.12 higher than PVB
(p>0.05). Subanalysis of group response of PI is 1.962 higher than
PVB. PI and PVB have the same risk to have pelvic lymph node metastasis,
but not parametrial metastasis. There were no differences
in terms of the risk of gastrointestinal, genitourinarius and hematologic
toxicity between PI and PVB.
Conclusion: There was no statistical difference in clinical and
pathological response, and also in acute toxicity between the two
combination (p>0.05).
[Indones J Obstet Gynecol 2016; 1: 47-51]
Keywords: acute toxicity, cervical carcinoma stage IB2, neoadjuvant
chemotherapy, respons
Impact of Ethinyl Estradiol to Human Telomerase Reverse Transcriptase Activity on Complete Hydatidiform Mole Culture
Get PDFObjective: To prove the effect of ethinyl estradiol as an activator on
human Telomerase Reverse Transcriptase (hTERT).
Method: The experimental study was conducted in vitro by using
culture of complete hydatidiform mole trophoblast cell. We exposed
the culture to ethinyl estradiol in varied doses and measured the
concentration of hTERT through RT-PCR quantitative. There were
40 specimens as control group and 20 specimens exposed to ethinyl
estradiol in different doses (10, 20, 40 and 80 mcg) as experimental
group. The activity of hTERT was measured by RT-PCR and the
concentration of it was assessed by ELISA. We analyzed the variables
using ANOVA, Turkey post hoc and Pearson correlation test.
Result: In control group, the concentration of hTERT was not detected.
Meanwhile, the concentration among different doses of
ethynil estradiol (10, 20, 40, 80 mcg) was 113,117.5; 114,507.6;
102,193.9; 127.546.1 amoles/ml, respectively. Among experimental
group, they were significantly different both using F test (ANOVA)
(p=0.001) and Turkey post hoc test (p=0.005). The correlation
among group was 0.84 which meant higher level of ethinyl estradiol
was correlated with higher activity of hTERT.
Conclusion: Ethinyl estradiol impacts to the increase of hTERT activity
on complete hydatidiform mole cell culture.
[Indones J Obstet Gynecol 2016; 4-2: 93-96]
Keywords: complete hydatidiform mole, ethinyl estradiol, human
Telomerase Reverse Transcriptase (hTERT
Tampilan integrin ανβ3 endometrium pada wanita infertil dengan penyakit radang panggul subklinik
Get PDFTujuan: Diketahuinya tampilan integrin ανβ3 pada wanita infertil
dengan penyakit radang panggul (PRP).
Rancangan/rumusan data: Penelitian bersifat klinis retrospektif.
Bahan dan cara kerja: Penelitian dilakukan pada 52 orang pasien
infertilitas dengan penyakit radang panggul subklinik yang datang ke
klinik Yasmin RSCM. Dilakukan biopsi endometrium pada hari ke 20-
24 siklus haid. Hasil biopsi dianalisa dengan pemeriksaan imunositokimia
di Makmal terpadu RSCM-FKUI. Hasil pewarnaan dievaluasi
untuk mendapatkan HSCORE.
Hasil: Didapatkan 26 sampel (50%) dengan intensitas lemah, 16
sampel (30,7%) dengan intensitas sedang, 5 sampel (9,6%) dengan intensitas
kuat dan 3 sampel (5,7%) dengan intensitas sangat kuat.
Kesimpulan: Intensitas tampilan integrin endometrium yang rendah
pada 50% pasien infertilitas dengan penyakit radang panggul subklinik,
menunjukkan kemungkinan adanya kaitan sebab-akibat antara
penyakit radang panggul dan kejadian infertilitas.
[Maj Obstet Ginekol Indones 2006; 30-2:116-9]
Kata kunci: integrin ανβ3, reseptivitas endometrium, hidrosalping,
imunositokimia
Pengaruh Isoflavon Terhadap Profil Lipid pada Perempuan Menopause/pascamenopause
Get PDFTujuan: Untuk menentukan efek perubahan profil lipid pada perempuan
menopause/pascamenopause yang diberi fitoestrogen (isoflavon).
Tempat: Poliklinik Menopause RSCM/FKUI Jakarta.
Rancangan/rumusan data: Uji klinis cara tersamar ganda dengan
desain paralel tanpa matching.
Bahan dan cara kerja: Selama kurun waktu April 2005 - September
2005, terkumpul 48 orang perempuan menopause/pascamenopause
berusia < 65 tahun yang sehat, telah mengalami henti haid minimal selama
1 tahun dengan kadar FSH ≥ 30 mIU/L. Setelah dilakukan randomisasi
sederhana dengan tabel random dan tersamar ganda, subjek
penelitian dibagi dua kelompok, kelompok pertama diberi obat fitoestrogen
isoflavon oral 100 mg/hari (2 x 50 mg), kelompok kedua diberi
plasebo oral. Sebelum minum obat, diperiksa kadar lipid serum berupa
kolesterol total, LDL kolesterol, HDL kolesterol dan trigliserida. Pemeriksaan
kadar lipid serum kedua diperiksa setelah minum obat selama
12 minggu untuk melihat perubahan profil lipid setelah minum obat.
Hasil: Dari 48 orang yang ikut penelitian, 2 orang dikeluarkan dari
penelitian. Ditemukan kenaikan rerata kadar kolesterol total serum
setelah 12 minggu pada kelompok obat sebesar -17,21 mg/dl (8,1%),
tetapi secara statistik tidak bermakna. Pada kelompok plasebo sebesar
-33,04 mg/dl (15%), secara statistik tidak bermakna. Pada kelompok
obat ditemukan kenaikan kadar LDL sebesar -20,43 mg/dl, lebih sedikit
dibanding kelompok plasebo sebesar -30,92 dan secara statistik bermakna
setelah minum obat. Ditemukan penurunan kadar rerata HDL sebesar
3,99 mg/dl, secara statistik tidak bermakna pada kelompok obat
setelah 12 minggu. Pada kelompok plasebo ditemukan kenaikan sebesar
1,40 dan tidak bermakna secara statistik. Pada kedua kelompok obat dan
plasebo terdapat kenaikan rerata kadar trigliserida (secara statistik tidak
bermakna) yaitu berturut-turut sebesar 3,54 mg/dl dan 4,16 mg/dl.
Kesimpulan: Tidak ditemukan perubahan profil lipid pada pemberian
isoflavon 100 mg/hari selama 12 minggu pada perempuan menopause/
pascamenopause yang sehat.
[Maj Obstet Ginekol Indones 2006; 30-3: 156-63]
Kata kunci: profil lipid, perempuan menopause/pascamenopause,
isoflavon
Operasi Mikro Rekanalisasi Tuba Per Laparoskopi (Laporan Kasus)
Get PDFTujuan: Untuk mengevaluasi hasil luaran dari prosedur operasi
mikro rekanalisasi anastomosis tuba fallopii dengan laparoskopi.
Tempat: Klinik Raden Saleh, Divisi Kesehatan Reproduksi, Departemen
Obstetri dan Ginekologi, FKUI/RSUPNCM.
Bahan dan cara kerja: Dilaporkan 3 kasus. Kasus pertama: Ny. A,
38 tahun, P3A0 (anak terkecil 3 tahun), sterilisasi 3 tahun, menikah 1 x,
usia suami 41 tahun, ingin punya anak lagi karena sosial ekonomi membaik.
Kasus kedua: Ny. I, 44 tahun, P3A0 (anak hidup 1), riwayat bekas
seksio 1 x, nikah 1 x, usia suami 48 tahun, ingin punya anak lagi karena
dua anak terakhir meninggal. Kasus ketiga: Ny. S, 40 tahun, P3A0 (anak
terkecil 8 tahun), sterilisasi 8 tahun lalu, cerai dengan suami pertama 5
tahun lalu, menikah lagi 2 tahun lalu, ingin punya anak lagi karena desakan
suami kedua, telah gagal menjalani IVF satu tahun yang lalu.
Hasil: Rekanalisasi tuba dengan laparoskopi telah dilakukan pada
ketiga pasien. Pada pasien pertama dan kedua dilakukan rekanalisasi
pada kedua tuba dengan hasil pascaoperasi kedua tuba paten. Pada
pasien ketiga tuba kanan oklusi diproksimal, sehingga hanya pada tuba
kiri yang dilakukan rekanalisasi dengan hasil tuba kiri paten.
Kesimpulan: Pada ketiga kasus rekanalisasi tuba dilakukan karena
keinginan kuat dari masing-masing pasangan suami istri dengan alasan
yang berbeda. Pada kasus-kasus yang diseleksi laparoskopi dengan
teknik khusus memakai instrumen mikro KOH (dengan diameter alat
masing-masing 2,5 mm) dapat ditawarkan untuk rekanalisasi tuba. Seleksi
pasien dan teknik operasi yang baik adalah faktor kunci untuk
mencapai angka kehamilan yang memuaskan. Hasil luaran pada ketiga
kasus hanya dinilai pada tahap patensi tuba, sedangkan hasil luaran kehamilan
belum dapat dinilai karena laporan ini dibuat baru 7 bulan berjalan.
[Maj Obstet Ginekol Indones 2006: 30-4: 234-7]
Kata kunci: rekanalisasi tuba, laparoskop
