Indonesian Journal of Obstetrics and Gynecology (INAJOG)
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Effect of Pyridoxine on Prostaglandin Plasma Level for Primary Dysmenorrheal Treatment: Pengaruh Pemberian Piridoksin terhadap Kadar Prostaglandin Plasma sebagai Terapi Dismenore Primer
No full textObjective : To determine the effect of vitamin B6 (pyridoxine) the levels of prostaglandins and intensity of pain in primary dysmenorrheal.
Methods : The levels of prostaglandin (PGF2α) in plasma measured by ELISA and pain intensity by verbal rating scales conducted on 35 women with primary dysmenorrheal (n=35) supplemented with vitamin B6 100mg for 4 days and controls with placebo (n=35).
Results : Prostaglandin levels decreased significantly after vitamin B6 supplementation (2212.9+1374.2 vs 1490.3+1119.0; p<0.05) followed by a significant reduction in pain intensity (4.29+0.7 vs 1.71+0.5; p<0.05) in the test group compared to control.
Conclusion : Due to vitamin B6 effects on decreasing prostaglandin levels and pain of primary dysmenorrheal, so that B6 vitamin can become the treatment for the primary dysmenorrheal.
Keywords : Primary dysmenorrheal, pyridoxine, prostaglandin
Tujuan: Untuk mengetahui pengaruh pemberian vitamin B6 (piridoksin) terhadap kadar prostaglandin dan intensitas nyeri pada dismenore primer.
Metode: Pemeriksaan kadar prostaglandin (PGF2α) dengan ELISA dan pengukuran intensitas nyeri dengan verbal rating scales dilakukan pada 35 orang (n=35) wanita dengan dismenore primer yang mendapatkan vitamin B6 100mg selama 4 hari dan kontrol yang mendapatkan plasebo (n=35).
Hasil: Kadar prostaglandin menurun bermakna setelah pemberian vitamin B6 (2212,9+1374,2 vs 1490,3+1119,0; p<0,05) disertai dengan penurunan intensitas nyeri yang bermakna (4,29+0,7 vs 1,71+0,5; p<0,05) pada kelompok uji dibandingkan kontrol.
Kesimpulan: Vitamin B6 menurunkan kadar prostaglandin dan nyeri sehingga vitamin B6 dapat dipertimbangkan menjadi salah satu pengobatan dismenore primer.
Kata kunci : Dismenore primer, piridoksin, prostaglandi
Conformity of Human Papillomavirus between Self-examination of Vaginal Fluid and Cervical Specimen with Fluid-Based Cytology in Precancerous Lesions: Tingkat Kesesuaian Human Papillomavirus antara Pemeriksaan Cairan Vagina secara Mandiri dan Spesimen Serviks dengan Sitologi Berbasis Cairan pada Lesi Prakanker
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Objective: To determine the conformity of human papillomavirus between self-examination of vaginal specimen and cervical specimen with fluid-based cytology in precancerous lesions.
Methods: A cross-sectional study performed on cervical and vaginal fluid from 90 pre-cancerous lesions patients from April to September 2016. Cytological examination performed with self-examination and liquid-based cytology technique. HPV genotyping performed with PCR technique. Data were analyzed with SPSS.
Results: Most of the women aged >35 years (89%), 78% (71/90) multiparity and 74.4% (67/90) do not know about HPV screening. High risk type found in both vaginal and cervical fluid was type 16, 18, 33 and 45 whereas type 35 found only in vaginal fluid. The most prevalent high-risk HPV for both specimens were type 16 and 18. HPV type 42 and 53 were the low risk HPV found in the vaginal and cervical specimens (table 2). Cohen’s kappa for inter-test agreement shows a strong correlation (r=0.864).
Conclusion: The HPV self-examination method can be used as a primary examination of cervical cancer lesions detection in addition to fluid-based cytology with the similar results.
Keywords: Human papillomavirus, self-examination, fluid-based cytology, cervical cancer
Abstrak
Tujuan: Untuk mengetahui tingkat kesesuaian antara pemeriksaan HPV mandiri dari spesimen vagina dan hasil pemeriksaan sitologi berbasis cairan dari spesimen serviks.
Metode: Penelitian cross-sectional dilakukan pada cairan serviks dan vagina dari 90 pasien lesi pra-kanker pada April sampai September 2016. Pemeriksaan sitologi dilakukan dengan pemeriksaan diri dan teknik sitologi berbasis cairan. Pemeriksaan genotip HPV dilakukan dengan teknik PCR. Data dianalisis dengan SPSS.
Hasil: Sebagian besar wanita dalam penelitian iniaberusia >35 tahun (89%), 78% (71/90) multiparitas dan 74,4% (67/90) tidak mengetahui tentang skrining HPV. Tipe HPV risiko tinggi yang ditemukan pada cairan vagina dan serviks adalah tipe 16, 18, 33 dan 45 sedangkan tipe 35 hanya ditemukan pada cairan vagina. Tipe HPV risiko tinggi yang dominan untuk kedua spesimen adalah tipe 16 dan 18. HPV tipe 42 dan 53 adalah HPV risiko rendah yang ditemukan pada baik spesimen vagina maupun serviks. Kappa Cohen untuk tingkat kesesuaian antara pemeriksaan mandiri dan sitologi berbasis cairan menunjukkan korelasi kuat (r = 0,864).
Kesimpulan: Metode pemeriksaan HPV secara mandiri sendiri dapat digunakan sebagai pemeriksaan primer deteksi lesi kanker serviks selain sitologi berbasis cairan dengan hasil yang sama
Relationship between Vaginal Sialidase Levels with Threatened of Preterm Labour
Get PDFObjective: To investigate the association between vaginalsialidase levels and threatened of preterm labor.Methods: A cross sectional study design was used. Subjects weredivided into two groups; the first group were pregnant women withthreatened of preterm labour, whereas the second were pretermpregnant women in Prof. Dr. R.D. Kandou Manado hospitals andnetwork hospitals, during the period between August 2016 andOctober 2016. Data were analyzed with SPSS version 20 to see thesignificancy levels.Results: From the 16 pregnant women with threatened ofpreterm labor and 16 pregnant women with preterm pregnant,the statistical t test showed that there were significant differencesaverage level of sialidase vagina between the threatened ofpreterm labor and preterm pregnant group (p = 0.000).Conclusion: There is a relationship between the incidencethreatened of preterm labor with vaginal sialidase levels.Keywords: bacteria, threat of preterm labour, vaginal sialidas
Vaginal Delivery in Placental Abruption: Persalinan Pervaginam pada Solusi Plasenta
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Objective: To describe the case of vaginal delivery in placental abruption.
Methods: A case report
Results: In the case of placental abruption, we could perform vaginal delivery.
Conclusion: The treatment of placental abruption can be vaginally or by cesarean section depending on the severity of disease, gestational age, and state of the mother and fetus.
Keywords: IUFD, placental abruption, vaginal deliver
Hypertriglyceridemia is associated with the incidence of preeclampsia: Hubungan Profil Lipid Serum pada Kehamilan Trimester Kedua dengan Kejadian Preeklamsia
No full textAbstract
Objective: to find out the correlation between lipid profille at trimester II of pregnancy and the incidence.of preeclampsia
Method : The research was conducted in the Polyclinic of Hasanuddin University Teaching Hospital, Department of Obstetrics and Gynecology of the Faculty of Medicine, and it network in Makassar city from March, 2015 through March, 2016. The research used was the prospective cohort design.
Results : The examination of the lipid levels of 115 pregnant mothers, aged 24-28 weeks. The mothers were then observed whether they experienced preeclampsia up to the time they gave birth or not. In the end, 8 subjects (6.9%) experienced preeclampsia and 107 subjects (93.1%) have no preeclampsia. The statistical analyses used Fisher’s Exact test and Mann Whitney test. The research results indicated that the mean value of the total cholesterol and Low Density Lipoprotein (LDL) was higher in the preeclampsia group compared to the non-preeclampsia group: 267.37 ± 64.12 : 238 ± 37.98; 177.38 ± 55.38 : 157.24 ± 35.08 (p>0.05). The mean value of High Density Lipoprotein (HDL) was lower in the preeclampsia group compared to the non-preeclampsia group: 64.75 ± 14.64 : 67.86 ± 16.72 (p>0,05). The mean value of trigliserida in preeclampsia group was significantly higher (19,5%) compared thanin the non-preeclampsia group: 260.12 ± 58.86 vs 209.14 ± 65.10 (p=0,027).
Conclusion : The hypertrigliseridemia was correlated with the preeclampsia incidence.
Keywords:preeclampsia, lipid profile, trimester II of pregnancy
Abstrak
Tujuan: mengetahui hubungan antara profil lipid kehamilan trimester II dengan kejadian preeklamsia.
Metode : Penelitian dilaksanakan di Poliklinik RS jejaring pendidikan Departemen Obstetri dan Ginekologi Fakulltas Kedokteran Universitas Hasanuddin dan Poliklinik Kesehatan Ibu dan Anak di beberapa Puskesmas Kota Makassar selama Maret 2015 sampai dengan Maret 2016. Rancangan penelitian yang digunakan adalah prospektif kohort.
Hasil: dari 115 ibu hamil dilakukan pemeriksaan kadar lipid, 115 ibu hamil pada usia kehamilan 24 – 28 minggu, kemudian diamati apakah subyek mengalami preeklamsia hingga proses persalinan. Terdapat delapan subyek (6,9%) berkembang menjadi preeklampsia dan 107 subyek tidak preeklamsia. Data dianalisis secara statistik dengan menggunakan uji Fisher’s Exact dan uji Mann Whitney. Hasil penelitian menunjukkan bahwa nilai mean kolesterol total dan Low Density Lipoprotein (LDL) lebih tinggi pada kelompok preeklampsia dibandingkan kelompok tidak preeklamsia, yaitu 267,37 ± 64,12 : 238,01 ± 37,98; 177,38 ± 55,38 : 157,24 ± 35,08 (p>0,05). Nilai mean High Density Lipoprotein (HDL) lebih rendah pada kelompok preeklamsia dibandingkan tidak preeklamsia yaitu 64,75 ± 14,64 : 67,86 ± 16,72 (p>0,05). Nilai mean trigli seri daripada kelompok preeklamsia secara signifikan lebih tinggi 19,5 % dibandingkan kelompok tidak preeklamsia, yaitu 260,12 ± 58,86 : 209,14 ± 65,10 (p=0,027).
Kesimpulan : Hiper trigli seridemia berhubungan dengan kejadian preeklamsia.
Kata kunci : preeklamsia, profil lipid, kehamilan trimester II
 
Effectiveness of Oral Probiotics as Adjuvant Therapy in Reproductive Aged Women with Vaginal Discharge
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Objective: To investigate the efficacy of oral proboiotics and prove the high proportion of cure and satisfaction levels of post-treatment patients with a combination of antimicrobial-probiotic oral Lactobacillus rhamnosus GR-1 and Lactobacillus reuteri RC-14 compared to a combination of antimicrobial-placebo in the treatment of reproductive aged patients with vaginal discharge in the outpatient obstetrics and gynecologic clinic in Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia and Arifin Achmad Regional Hospital Pekanbaru, Riau, Indonesia.
Methods:This was a randomized, double-blind, placebo-controlled trial involving50 subjects consisting of reproductive aged women. Data were collected using syndromic approach, probiotics were given as an adjuvant for standard antimicrobial therapy versus placebo as control, response was recorded 4 weeks later, for cure proportion and satisfaction level. Statistical analysis was performed to assess the variables. Interim analysis with conditional power assesment and futility testing were performed at midway due to insufficient sample size. Research was approved by Ethics Commitee for Health Researches Faculty of Medicine University of Indonesia-Dr. Cipto Mangunkusumo Hospital in March 2016.
Results: A total of 50 subjects participated in this study. and analyzed (25 subjects in each group), cure proportion 56%(14) of the treatment and 60%(15)on the control group, with relative risk of 1.1, Chi-square test p value (0.77, 95% CI; 0.57 to 2 , 11). High satisfaction level (score ≥67) was higher in the placebo (52,6%, 10 subjects) compared to probiotic group (47,4%, 9 subjects), p value 0,65 (≥0,05). Conditional power and futility testing curve, revealed Z = -0.2865, conditional power 0.11 to 0.13, and futility index of 0.87 to 0.88, equals to low possibility of statistical significance with full sample size (84).
Conclusion: There was no clinical and statistical difference in the proportion of cure rate and the level of satisfaction in patients of probiotics vs placebo groups after treatment for 4 weeks. The initial hypothesis of higher proportion of the cure ratein the treatment group still cannot be excluded, due to insufficient samples.
Keywords: bacterial vaginosis, , lactobacillus reuteri RC-14, lactobacillus rhamnosus GR-1, randomized double blind controlled trial, trichomoniasis , vaginal discharge, vulvovaginal candidiasis
Fetal Biometry Nomogram Based on Normal Population : an Observational Study: Nomogram Biometri Janin Berdasarkan Populasi Normal : Suatu Penelitian Observasional
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Objective: To establish fetal biometry nomogram using percentilemethod based on normal population.
Methods: A descriptive retrospective study in order to establishfetal biometry nomogram using percentile method basedon normal population. Four fetal biometry measurement (BPD,HC, AC and FL) was collected from ultrasonography examinationresult in Fetomaternal Division Ultrasound Unit - AnggrekClinic and from medical record unit Dr. Cipto MangunkusumoGeneral Hospital, from January 2015 until April 2016. Databeing documented using case report form and being tabulatedusing Microsoft Excell 2011 Version 14.7.0 (161029). All datawere analyzed using SPSS 20.0 dan Matlab R2016a.
Results: There were 6169 pregnant women underwent fetalbiometry ultrasound within January 2015 - April 2016. Basedon inclusion criteria, 2798 (45%) were eligible as researchsample distributed from 12 until 42 wga. Due to evenly distributiondata, 2205 (78%) were distributed from 20 until 40 wgato develop fetal biometry nomogram. Most pregnant womenwere 28.9 years old (SD  5.74) in range of 21-30 (55%) yearsold. The youngest was 13 years old and the oldest was 45years old. Four fetal biometry were collected and distributedevenly using percentile method to establish fetal biometrynomogram. As for estimated fetal weight curve was developedby Hadlock C formula. Each biometry was calculated the 10th,50th and 90th centile curves according to gestational age. Thus,representing the fetal biometry and modified Hadlock C estimatedfetal weight nomogram based on normal population inJakarta.
Conclusion: Each biometry and modified Hadlock C estimated fetalweight were calculated in 10th, 50th and 90th centile curves accordingto gestational age represent fetal biometry nomogram based onnormal population in Jakarta.
Keywords: biometry, estimated fetal weight formula, nomogra
Effectiveness of Oral Misoprostol to Prevent Postcesarean Section Urinary Retention: Efektivitas Misoprostol Per-oral terhadap Perubahan Residu Urine sebagai Pencegahan Retensio Urine Pascaseksio Sesaria
Get PDFObjective: to determine the effect of misoprostol on the incidence of urinary retention in post cesarean section patients by measuring maternal residual urine volume 6 hours after catheter removal.
Methods: This was a single-blind randomized controlled trial, at Department of Obstetrics and Gynecology Mohammad Hoesin Palembang Hospital from October 2016 to February 2017. Samples were patients who underwent cesarean section, either elective or emergencies treated at Department of Obstetrics and Gynecology Hospital, Mohammad Hoesin Palembang. Subjects were allocated into two groups: treatment group (receiving misoprostol) and placebo group. Urinary retention is diagnosed if post-voiding residual urine volume after Foley catheter removal was > 200 ml. Statistical analysis was performed using SPSS 17.0
Results: There were no differences in mean time between of urination between control group (placebo) and 600μg oral misoprostol group. The average of urine volume, and residual urine volume between control group (placebo) and 600μg oral misoprostol group was significantly different. 600μg misoprostol orally can increase the amount of urine and reduce the volume of urinary residue after cesarean section.
Conclusion: 600μg oral misoprostol can increase urine volume and reduce volume of residual urine post cesarean section
Keywords: Misoprostol, urinary retention, cesarean section
Tujuan: untuk mengetahui pengaruh misoprostol terhadap kejadian retensi urin pada pasien operasi seksio sesaria dengan mengukur volume residu urin maternal 6 jam setelah kateter dilepaskan.
Metode: Penelitian uji klinik acak berpembanding (Randomized Controlled Trial) secara single blind (tersamar tunggal) ini dilakukan di Departemen Obstetri dan Ginekologi RSUP Mohammad Hoesin Palembang mulai bulan Oktober 2016 sampai dengan Februari 2017. Sampel penelitian adalah semua pasien seksio sesaria, baik elektif maupun emergensi yang dirawat di Departemen Obstetri dan Ginekologi RSUP Mohammad Hoesin Palembang. Subjek dialokasikan menjadi 2 kelompok yaitu kelompok penanganan yang menerima misoprostol dan kelompok placebo. Retensio urin didiagnosis jika volume residu urin pasca berkemih setelah kateter Foley dilepaskan >200 ml. Analisis statistik dilakukan dengan menggunakan SPSS 17.0
Hasil:Tidak terdapat perbedaan rerata waktu urinasi antara kelompok kontrol (plasebo) dengan misoprostol peroral 600µg.Terdapat perbedaan rerata jumlah urine, dan volume residu urine antara kelompok kontrol (plasebo) dengan misoprostol peroral 600µg. Misoprostol per oral 600µg dapat meningkatkan jumlah urin dan mengurangi volume residu urin pasca persalian seksio sesaria.
Kesimpulan:. Misoprostol per oral 600µg dapat meningkatkan jumlah urin dan mengurangi volume residu urin pasca persalian seksio sesaria
Kata kunci: Misoprostol, retensio urin, seksio sesari
The Risk of Infection Human Papilloma Virus Infection in Acceptors of Depot Medroxyprogesterone Acetate Contraceptions
Get PDFObjective: Cervical cancer is the second most prevalent cancer inwomen around the world and the most common cancer in womencausing death. This study aims to analyze the connection betweeninfection of human papilloma virus (HPV) 16/18 and cervicalchanges in the acceptors of Depot Medroxyprogesterone Acetate(DMPA) Contraceptions and nonacceptors of Depot MedroxyprogesteroneAcetate (DMPA) Contraceptions.Methods: The research was conducted at the Public ServiceInstitution of Dr. Wahidin Sudirohusodo hospital, and privatemidwife clinics for seven months from December 2015 to June 2016.The research design is cross-sectional with. The samples were fortyacceptors of Depot Medroxyprogesterone Acetate (DMPA) and fortynon-acceptors of Depot Medroxyprogesterone Acetate (DMPA)contraception. Prevalence of HPV 16/18 and cervical cytologychanges were examine using the polymerase chain reaction andliquid base cervical cytology.Results: The results showed there was no significant relationshipbetween long-term use of DMPA contraceptives with HPV 16 and 18.There was no significant relationship between long-term use ofDMPA contraceptives with cervical cytology changes. There was nosignificant relationship between HPV 16 and 18 infections with theoccurrence of cervical cytology changes in long-term use of DMPAcontraceptives.Conclusion: The long-term use of DMPA contraceptive does notincrease the risk of HPV 16 and 18 infections. Also does not causecervical cytology changes that lead to cervical malignancy.Keywords: cervical cytology changes, Depot MedroxyprogesteroneAcetate (DMPA) contraception, HPV 16/18 infectio
Different Doses of Intraumbilical Oxytocin on the Third Stage of Labor: Berbagai Dosis Oksitosin Intraumbilikal pada Manajemen Aktif Kala III
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Objective: To compare the dose of oxytocin injected intraumbilicalltowards the duration of the third stage, blood loss volume, hemoglobinand hematocrit.
Methods: This study is a prospective randomised study with acontrol. The control group was given an intramuscular injection of10 IU oxytocin. The intervention of the three groups intraumbilicaloxytocin treatment dose of 10 IU, 20 IU and 30 IU diluted in 50 ml ofnormal saline solution and administered intraumbilically. Thesample selection by purposive sampling and the distribution groupbased on systematic random sampling (10 samples each). Data weretaken from the period April 2016-January 2017 with the inclusionand exclusion criteria. Data were analysed using Chi-square, T-test,ANOVA and Post hoc tests.
Results: Characteristics study for variables of age, occupation,parity, education, episiotomy and neonates weight showed homogeneouscharacteristics. The mean duration of the third stage forall groups was between 366.7  159.0 seconds and 440.1  244.99seconds. While the average number of postpartum haemorrhage forall group 61.894  226.3ml and 309.5  110.26 ml. There were nodifferences in the dose of oxytocin on the duration of the thirdstage (p> 0.05) and the amount of bleeding (p> 0.005). There was adifference of haemoglobin between intervention group of oxytocindose of 10 IU and 30 IU intraumbilical (p = 0.031). There was nodifference between the mean hematocrit levels between the groups(p> 0.005).
Conclusion: There were no differences in the dose of oxytocinintraumbilical towards the duration of the third stage, the amountof bleeding and hematocrit levels. The decrease of haemoglobingreater in 30 IU intraumbilical significantly.
Keywords: duration of the third stage, haemoglobin and hematocrit,oxytocin intraumbilical, the amount of bleedin