Indonesian Journal of Obstetrics and Gynecology (INAJOG)
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Diagnostic Value of Transvaginal Ultrasonography to Determined Degree of Myometrium Invasion in Endometrial Cancer: Nilai Diagnostik Ultrasonografi Transvaginal dalam Menilai Kedalaman Invasi ke Miometrium pada Kanker Endometrium
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Objectives: To show transvaginal ultrasound accuracy in determining the degree of myometrial invasion of endometrial cancer within five years in RSCM. Also, to know histopathology characteristics of endometrial cancer according to cell type, degree of invasion, and degree of differentiation of endometrial cancer, within the last five years in RSCM.
Methods: This study is a cross-sectional study with a sample of 82 subjects in January 2011 – December 2016 at RSCM. The data were collected by total sampling from cancer registry oncology and gynaecology division of Obstetrics and Gynecology FKUI-RSCM.
Results: Transvaginal USG diagnostic test in detection invasion has sensitivity, specificity, PPV, and NPV as 78.79%, 50%, 86.67%, 36.36% respectively. For determine degree of myometrial invasion it has sensitivity, specificity, PPV, and NPV as 81.40%, 76.92%, 79.55%, and 78.90% respectively.
Conclusions: Transvaginal ultrasound has better accuracy in determining the degree of invasion compared to detecting myometrial invasion in endometrial cancer. In determining the degree of invasion, its sensitivity and specificity are 81.4% and 76.92%. For detecting any invasion its sensitivity and specificity was only 79.41% and 57.14%. Our study showed that transvaginal ultrasound was an efficient diagnostic tool fo determine further treatment and prognosis in endometrial cancer
Keywords: accuracy test, HPV DNA, liquid-based cytology, pre-cervical cancer lesion.
Abstrak
Tujuan : Mengetahui akurasi USG transvaginal dalam menilai invasi miometrium pada kanker endometrium dalam 5 tahun terakhir di RSCM. Serta karakteristik histopatologi berdasarkan tipe, invasi, dan derajat diferensiasi kanker endometrium dalam 5 tahun terakhir di RSCM
Metode :Penelitian potong lintang dengan jumlah sampel 82 subjek pada Jan 2011 – Des 2016 di RSCM. Data dikumpulkan secara total sampling dari registrasi kanker divisi Onkologi Ginekologi FKUI RSCM dan dilakukan uji diagnostik
Hasil: Uji diagnostik USG transvaginal menilai ada tidaknya invasi memiliki sensitivitas, spesifisitas, NPP, NPN sebesar 78,79%, 50%, 86,67%, 36,36%. Sedangkan hasil uji diagnostik usg transvaginal dalam menilai derajat invasi memiliki sensitivitas, spesifisitas, NPP, NPN sebesar 81.40%, 76.92%, 79.55%, dan 78.90%
Kesimpulan :USG transvaginal dalam menilai derajat invasi lebih baik dibanding menentukan ada tidaknya invasi. Sensitivitas, spesifisitasnya 81,4-% dan 76,92% dibanding 79,41% dan 57,14%. Dalam hal ini USG transvaginal dapat digunakan sebagai alat bantu diagnostik efisien dalam menentukan tata laksana dan prognosis kanker endometrium
Kata kunci : kanker endometrium, kedalaman invasi, uji diagnostik, USG transvaginal
Sacrospinosus Fixation Efectivity in Pelvic Organ Prolapse Patient: Efektivitas Fiksasi Sakrospinosus pada Penderita Prolaps Organ Panggul
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Background : Pelvic organ prolapse (POP) is a condition in which interna genitalia protrude into vagina, or even out of vagina. This occur due to weaknesses of pelvic muscle, fascia and ligaments support. Sacrospinous ligament fixation (SSF) is an ideal vaginal procedure for POP repair with 90-95% success rate. This study aims to determine the effectiveness of SSF in patients with POP at dr. Mohammad Hoesin hospital (RSMH) Palembang
Method: Randomized clinical trial (RCT) was performed at RSMH Palembang from January to September 2017. There were 30 samples of pelvic organ prolapse who met the inclusion criteria. Data frequency and distribution were described in table form and the effectiveness of SSF were analyzed by Wilcoxon / paired t-test while the effectiveness ratio was analyzed by Mann Whitney / independent t-test. Data were analyzed using SPSS version 16.0.
Result: There were no differences in patient characteristics (age, parity, body weight, height, and occupation) between the two treatment groups (p <0.05). There were differences of breech pain (proctalgia) before and after 1, 3, and 6 months post operation in SSF group (p <0.05), in which proctalgia was more exquisite after than before surgery. The results showed that SSF was effective in reducing urinary disorders, defecation disorders, vaginal prolapse, cystocele and rectocele, and effectively improving the quality of life of POP patient. In addition, there was a difference of proctalgia and vaginal prolapse 1, 3, and 6 months after surgery between two groups where the adverse outcome of the proctalgia was more significant in SSF group but the vaginal prolapse was more significant in the non-SSF group. There were no differences in bleeding complications (p = 1,000) and infection (p = 1,000) between the two groups.
Conclusion: Sacrospinosus Fixation was effectively reduces the vaginal prolapse of pelvic organ prolapse patients.
Keywords: Urinary, Defecation, Sacrospinosus Fixation, Quality of Life, Proclatgia, Rectocele, Cystocele.
Abstrak
Latar Belakang:. Prolapsus organ panggul (POP) merupakan keadaan dimana suatu organ genitalia turun kedalam vagina, bahkan mungkin keluar liang vagina. Hal ini terjadi dikarenakan kelemahan otot, fasia dan ligamen penyokongnya. Sacrospinous ligament fixation (SSF) adalah prosedur vaginal yang ideal untuk perbaikan POP dengan tingkat keberhasilan 90-95%. Penelitian ini bertujuan untuk mengetahui efektivitas SSF pada penderita prolaps organ panggul di rumah sakit dr. Mohammad Hoesin (RSMH) Palembang
Metode: Uji klinis acak berpembanding (RCT) dilakukan di RSMH Palembang sejak bulan Januari sampai September 2017. Didapatkan sampel sebanyak 30 penderita prolaps organ panggul yang memenuhi kriteria inklusi. Frekuensi dan distribusi data dijelaskan dalam bentuk table dan efektivitas SSF dianalisis dengan uji Wilcoxon/paired t-test dan perbandingan efektivitas dianalisa dengan uji Mann Whitney/independent t-Test menggunakan SPSS versi 16.0.
Hasil: Analisis statistik tidak terdapat perbedaan karakteristik pasien baik umur, paritas, berat badan, tinggi badan, dan pekerjaan antara kedua kelompok perlakuan (p< 0,05). Didapatkan bahwa SSF efektif mengurangi gangguan berkemih, gangguan defekasi, prolaps vagina, sistokel dan rektokel serta meningkatkan kualitas hidup pasien POP, namun terdapat perbedaan nyeri bokong (proktalgia) sebelum dan sesudah 1 bulan, 3 bulan dan 6 bulan operasi pada group SSF (p <0,05). dimana proktalgia lebih dirasakan setelah operasi dibandingkan sebelum operasi. Selain itu terdapat perbedaan proklatgia dan prolaps vagina 1,3 dan 6 bulan setelah operasi antar kedua group dimana proktalgia lebih dirasakan pada kelompok SSF namun prolaps vagina lebih banyak dialami oleh kelompok non SSF. Tidak terdapat perbedaan komplikasi perdarahan (p = 1,000) dan infeksi (p = 1,000) antara kedua kelompok.
Simpulan: Fiksasi sakrospinosus efektif mengurangi prolaps vagina pasien prolaps organ panggul.
Kata Kunci:. Berkemih, Defekasi, Fiksasi sacrospinosus, Kualitas Hidup, Nyeri Bokong, Rektokel, Sistoke
 
The Role of Maternal Progesterone and Estradiol Levels in Predicting the Success of Induction of Labour: A Preliminary Study: Hubungan Kadar Progesteron dan Estradiol Ibu terhadap Keberhasilan Induksi Persalinan: Suatu Studi Pendahuluan
Get PDFObjective: to evaluate whether maternal progesterone and estradiol levels could be used to predictthe success ofinduction of labour (IOL)
Methods:This cross-sectional study was conducted at the Women’s Health Clinic as well as delivery suite of Dr. Cipto Mangunkusumo Hospital during the period of May 2016 to April 2017. Blood samples of term pregnant women who were indicated for IOL wereobtainedbefore birth.
Results:A total 44 subject were recruited in this study.Of these, 24 subjects had successful IOL while the other 20 subjects had IOL failure. There was no significant difference of progesterone among both groups (66,7% vs 75%, p=0,55). The estradiol levels in subjects who successfully performed induction had an average of 16,916.28 ± 2,574.75 pg/mL which did not differ significantly from the failed of induction group with estradiol levels of 14,832.24 ± 2374.47 pg/mL (p = 0,65).
Conclusion:We found no significant association between both maternal progesterone and estradiol levels and the success rate of IOL. Further studies with larger sample sizes are required to confirm whether progesterone and estradiol play pivotal roles in the success of IOL.
Keywords: progesterone, estradiol, induction of labour
Tujuan: mengevaluasi kadar progesteron dan estradiol ibu sebagai prediktor kesuksesan induksi persalinan
Metode: Penelitian ini menggunakan desain potong lintang yang berlangsung pada bulan Mei 2016 hingga April 2017 di Poliklinik dan IGD Kebidanan Rumah Sakit Umum Pusat Rujukan Nasional Cipto Mangunkusumo. Pasien hamil aterm yang dilakukan induksi persalinan dan memenuhi kriteria penelitian akan diambil sampel darah sebelum persalinan.
Hasil: Dari 44 subjek yang mengikuti penelitian, 24 subjek berhasil dilakukan induksi persalinan dan 20 subjek gagal.Tidakterdapatperbedaanbermaknapadakadarprogesterone
Antarakeduagrup(66,7% vs 75%, p=0,55). Kadar estradiol padapasien yang berhasildilakukaninduksimemiliki rata-rata 16.916,28 + 2.574,75pg/mL yang tidakberbedajauhdengankadar estradiol pasien yang gagalinduksiyaitu 14.832,24 + 2374,47pg/mL (p = 0,65).
Kesimpulan: Tidakterdapat perbedaan bermakna antara kadar progesteron dan estradiol maternal terhadap keberhasilan induksi persalinan. Penelitian lebih lanjut dengan jumlah sampel yang lebih besar dibutuhkan untuk mengkonfirmasi hubungan ini dengan lebih baik.
Kata kunci: progesteron, estradiol, induksi persalina
Making Diagnostic of Gestational Trophoblastic Neoplasia : What, When, How to Treat and What to do Next ?
Get PDFA delay on diagnosing Gestational Trophoblastic Neoplasia (GTN) may cause increase of morbidity to the patient. The important things that OBGYN usually forgot is that GTN may develop not only from previous molar gestation (50-60%), but also from abortions or ectopic pregnancy (25-30%) and term or preterm deliveries (10-25%).1,2This can cause a delay on diagnosing that may increase the GTN score from low risk become high risk, such as this case, as follow
The Association between Preeclampsia and Newborn Hearing Loss: Hubungan antara Preeklamsia dengan Penurunan Pendengaran pada Bayi Baru Lahir
Get PDFObjective: to analyze the relationship between PE and the newborn hearing loss
Method : Analytic observation research withcross sectionaldesign performed inRSMHPalembangsince December 2016 to July 2017, obtained 48 aterm neonates born from mother diagnosed with PE (11 PE and 37 severe PE). Measurements of neonatal hearing loss then performed using emission otoacoustics (OAE) in both ears by ENT division with catagories intepretation of pass and refer. The mothers were physically check and interviewed to obtain demographic data and obstetric history. After the data normality were proved byShapiro Wilktest, we performed bivariate analysis using X2test on demographic and obstetric characteristics of the mother, neonatal demographic characteristics, and determine the relationship of PE with OAE result. The ratio of systolic (SBP) and diastolic (DBP) blood pressure to neonatal hearing loss was determined by independent T test and ROC test. Multivariate analysis was performed to determine the maternal and neonatal risk factors that influenced neonatal hearing loss. Data analysis using SPSS version 18.0.
Results : There were no significant differences in maternal and neonatal demographic characteristics in neonatal hearing loss (p> 0.05). No significant relationship was found between PE and OAE of both ear (right, p = 0,437; left, p = 0,368). There was difference of mean of SBP and DBP of mother inneonate OAE of both ears (p <0,05) with cut off point of SBP 160 mmHg and DBP 106 mmHg.There was a significant association between DBP (> 106 mmHg) of the mother and birth weight of the fetus (< 2500 g) with referOAE.
Conclusion: There was a significant association between neonatal hearing loss and maternal PE, determined primarily by maternal DBP, and neonatal birth weight.
Keywords: maternal blood pressure, OAE,preeclampsia,
Abstrak
Tujuan: untuk menilai hubungan PE ibu dengan penurunan pendengarah bayyi baru lahir
Metode: Penelitian observasi analitik dengan disain cross sectionaldilakukan di RSMH Palembang sejak Desember 2016 sampai Juli 2017, diperoleh 48 neonatus aterm lahir dari ibu PE (11 PER dan 37 PEB). Neonatus dilakukan pengukuran pendengaran menggunakan otoakustik emisi (OAE) pada kedua telinga oleh divisi THT dengan kategori intepretasi refer dan pass. Ibu dilakukan pemeriksaan dan wawancara untuk memperoleh data demografi dan riwayat obstetri. Setelah normalitas data dibuktikan dengan tes Saphiro Wilk, dilakukan analisis bivariat menggunakan tes X2 pada karakteristik demografi dan obstetri Ibu, karakteristik demografi neonatus, dan menentukan hubungan preeklampsia dengan hasil OAE. Perbandingan tekanan darah sistolik (TDS) dan diastolik (TDD) terhadap penurunan pendengaran neonatus ditentukan dengan independent T test dan uji ROC. Analisis multivariat dilakukan untuk menentukan faktor risiko Ibu maupun neonatus yang berpengaruh terhadap penurunan pendengaran neonatus. Analisa data menggunakan SPSS versi 18.0.
Hasil: Tidak ditemukan perbedaan signifikan karakteristik demografi Ibu maupun neonatus tehadap penurunan pendengaran neonatus (p>0,05). Tidak ditemukan hubungan signfikan antara kondisi PE dengan OAE kanan (p = 0,437) dan kiri (p = 0,368). Ditemukan perbedaan rerata TDS dan TDD ibu terhadap OAE kedua telinga neonatus (p<0,05) dengan cut off point TDS 160 mmHg dan TDD 106 mmHg. Ditemukan hubungan signifikan antara TDD (>106 mmHg) ibu dan berat lahir janin (>2500 gr) dengan OAE refer.
Kesimpulan: Terdapat hubungan bermakna antara penurunan pendengaran neonatus dengan kondisi preeklampsia ibu, yang ditentukan terutama oleh TDD ibu, serta berat lahir bayi.
Kata kunci:, OAE, preeklamsia, tekanan dara
Accuracy of Fetal Weight Estimation Using Hadlock II Formula: Keakuratan Taksiran Berat Janin Menggunakan Rumus Hadlock II
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Objective: to investigate the accuracy of estimated fetal weight using Hadlock II formula in RSUD Dr Moewardi.
Methods: This cross-sectional study was conducted at RSUD Dr Moewardi in June 2017. Subjects were women who gave birth at RSUD Dr Moewardi from August 2014 to March 2017. The method of collecting data by quoting the medical record as required. Data analysis was done by using linear regression statistic test.
Result: By distribution, the number of samples that, according to the standard, is 81.67 %. With the value of R = 0.706 which means that the relationship between two research variables are strong and the value of R Square = 0.499 which means that estimated fetal weight using Hadlock II formula has contribution 49.9 % on fetal birth weight and 50.1 % others by other factors.
Conclusion: Fetal weight estimation using Hadlock II formula in RSUD Dr Moewardi has low accuracy. Operator skills training is required to improve the accuracy of estimated fetal weight.
Keywords: fetal birth weight, fetal weight estimation, Hadlock II
abstrak
Tujuan : Mengetahui keakuratan taksiran berat janin menggunakan rumus Hadlock II di RSUD Dr Moewardi.
Metode : Penelitian ini adalah penelitian observasional analitik. Penelitian ini dilaksanakan di RSUD Dr Moewardi pada Juni 2017. Subjek penelitian ini adalah data rekam medis dari ibu hamil yang mengalami partus di RSUD Dr Moewardi pada Agustus 2014 – Maret 2017. Metode pengumpulan data dengan mengutip data rekam medis pasien sesuai ketentuan. Analisis data dilakukan dengan uji statistik regresi linier.
Hasil : Secara distribusi, jumlah sampel yang memenuhi standar yaitu 81,67 %. Dengan nilai R = 0,706 yang artinya bahwa hubungan kedua variabel penelitian ada dalam kategori kuat dan nilai R Square = 0,499 yang berarti taksiran berat janin menggunakan rumus Hadlock II memiliki pengaruh kontribusi sebesar 49,9% terhadap berat bayi lahir sedangkan 50.1 % lainnya dipengaruhi oleh faktor lain.
Kesimpulan : Taksiran berat janin menggunakan rumus Hadlock II di RSUD Dr Moewardi kurang akurat. Perlu dilakukan pelatihan ketrampilan operator sehingga diharapkan dapat meningkatkan keakuratan taksiran berat janin.
Kata kunci: berat bayi lahir , Hadlock II, , taksiran berat jani
Estradiol Level and Psychosocial Stress in Perimenopausal Women: Kadar Estradiol dan Stres Psikososial pada Perempuan Perimenopause
Get PDFObjective : To determine the relationship between estradiol levels and psychosocial stress in the perimenopausal women.
Methods : Sixty perimenopausal included in a cross-sectional study from July to December 2016. Blood samples obtained from the women to measure the estradiol and the cortisol levels. Stress level measured with visual. Data presented as the mean and standard deviation (mean±SD) with p-value <.05 was considered statistically significant.
Results : There was no significant difference between the estradiol levels and the stress level (p=0.27) during perimenopause period. The estradiol levels were higher compared with the cortisol levels. The non parametrik correlations analysis show the estradiol levels were not correlated with the cortisol levels (p=0.352). However, the cortisol levels were correlated with the stress levels (p<0.05).
Conclusion : Estradiol does not cause psychosocial stress during perimenopause period in our study population
Keywords : Estradiol, psychosocial stress, perimenopaus
The Associated of Serum Inhibin A Levels in Severe Preeclampsia: Hubungan Kadar Inhibin A Serum pada Preeklamsia Berat
Get PDFObjective: to prove the associated of serum Inhibin A levels in severe preeclampsia.
Method: this study was an observational analytic research with cross-sectional design. The subject of this study consists of 23 samples of normotensive pregnancy and 23 of samples severe preeclampsia who meet the inclusion and exclusion criteria.This study was conducted and evaluated fromSeptember 2016 until December 2016 at Department of Obstetrics and Gynecology Faculty of Medicine University of Sam Ratulangi Prof. Dr. R. D. Kandou Hospital Manado and satellite hospitals. Samples were analyzed using ELISA method at Prodia laboratory. Data were analyzed with SPSS version 20.0
Result: Mean serum Inhibin A levels in normotensive pregnancy is 477,22pg/ml while mean in severe preeclampsiais 2712,39 pg/ml with p value = 0,000.
Conclusion: Levels of serum Inhibin A in severe preeclampsia significantly higher compared to normotensive pregnancy.
Keywords: inhibin A, normotensi, severe preeclampsia
Tujuan: untuk membuktikan hubungan kadar inhibin A serum pada preeclamsia berat.
Metode: penelitian ini merupakan studi analitik observasional dalam bentuk desain potong lintang. Dilakukan pemeriksaan kadar Inhibin A serum pada 46 sampel ibu hamil yang memenuhi kriteria inklusi dan eksklusi, terdiri atas 23 kelompok preeclamsia berat dan 23 kelompok kehamilan normotesi. Penelitian dilaksanakan dan dievaluasi sejak bulan September 2016 sampai Desember 2016 di Bagian Obstetri dan Ginekologi Fakultas Kedokteran Universitas Sam Ratulangi / RSU Prof. dr. R. D. Kandou Manado dan rumah sakit jejaring. Analisis sampel dilakukan di Laboratorium Prodia Jakartamenggunakan metode ELISA. Data dianalisis denganSPSS versi 20.0.
Hasil: rerata kadar Inhibin A serum pada kelompok kehamilan normotesi yaitu 477,22 pg/mlsedangkan rerata pada kelompok preeklamsia berat yaitu 271,.39 pg/ml dengan nilai p=,.000.
Kesimpulan: kadar Inhibin A serum pada preeclampsia berat lebih tinggi secara bermakna dibandingkan dengan kehamilan normotensi.
Kata kunci: inhibin A, normotensi, preeclamsia bera
Correlation between Body Mass Index and Lipid Profile in Second Trimester with Incidence of Hypertension in Third Trimester: Hubungan Index Massa Tubuh dan Profil Lipid Trimester II Dengan Kejadian Hipertensipada Trimester III
Get PDFAbstract Objective : to determine the relationship of BMI (Body Mass Index) and lipid profile (total cholesterol, triglycerides, HDL, LDL, VLDV) in the second trimester of pregnancy with the incidence of hypertension in the third trimester of pregnancy
Methods :this study is a prospective cohort. The research subjects were the second trimester pregnant women group which examined by BMI and lipid profile, then assessed the incidence of hypertension in third trimester. The study was conducted in Department of Obstetric and Gynecology and Prof.DR.RDKandou General Hospital, and affiliated hospital from January 2017 until May 2017. Data analyzed with SPSS version 2.0
Results:from 49 research subjects, based on age,most subject with age 20-34 years with 42 subjects (85.8%). Based on the parity obtained 27 subjects (55.2%) with multigravida. By education level, most are high school with 19 subjects (38,7%). From the occupation, most are housewives with 30 subjects (61.3%). Based on BMI, most were subjects with normal BMI with 21 subjects (42.9%). Pearson test showed a significant association between BMI with total cholesterol (r = 0,500 and p = 0,000), whereas Spearman test showed significant relation between BMI with LDL cholesterol (r = 0,416 and p = 0,003) and significant relation between second trimester LDL cholesterol with third trimester diastolic blood pressure(r = 0.303 and p = 0.034).
Conclusions:there was a significant correlation between BMI with total cholesterol & LDL in second trimester and there was significant correlation between LDL in second trimester and third trimesterdiastolic blood pressure.
Keywords:BMI,total cholesterol, VLDL, TG, LDL, HDL, hypertension.
Abstrak
Tujuan : Untuk mengetahui hubungan IMT (Index Massa Tubuh)danprofil lipid ( kolesterol total, trigliserida, HDL, LDL, VLDV) pada trimester kedua kehamilan dengan kejadian hipertensi pada trimester ketigak ehamilan.
Metode : Penelitian ini merupakan kohort prospektif. Subjek penelitian adalah kelompok ibu hamil trimester kedua yang diperiksa IMT dan profil lipidnya, kemudian dinilai kejadian hipertensi pada trimester ketiga. Penelitian dilakukan di Departemen Obstetri dan Ginekologi Rumah Sakit Umum Pusat (RSUP) Prof.DR.R.D Kandou, dan RS jejaring mulai Januari 2017 sampai Mei 2017. Data dianalisa dengan SPSS versi 2.0
Hasil : Dari 49 subjek penelitian, berdasarkan usia paling banyak usia 20 – 34 tahun dengan 42 subjek (85,8%). Berdasarkan paritas didapatkan 27 subjek (55,2%) dengan multigravida. Berdasarkan pendidikan, paling banyak adalah SMA dengan 19 subjek (38,7%). Dari jenis pekerjaan, paling banyak adalah ibu rumah tangga dengan 30 subjek (61,3%). Berdasarkan IMT, paling banyak adalah subjek dengan IMT normal dengan 21 subjek (42,9%). Uji Pearson menunjukkan hubungan bermakna antara IMT dengan kolesterol total (r = 0,500 dan p = 0,000), sedangkan Uji Spearman menunjukkan hubungan bermakna antara IMT dengan kolesterol LDL (r = 0,416 dan p = 0,003) dan hubungan bermakna antara kolesterol LDL trimester kedua dengan tekanan darah diastol trimester ketiga (r = 0,303 dan p = 0,034).
Kesimpulan : Terdapat hubungan bermakna antara IMT dengan kolesterol total, LDL trimester kedua dan terdapat hubungan bermakna antara LDL trimester kedua dengan tekanan darah diastol trimester ketiga.
Kata kunci :IMT, kolesterol total, VLDL, TG, LDL, HDL, hipertensi
Differences of Vitamin D Level in Non-pregnant Reproductive Age Women and First Trimester Pregnant Women: Perbedaan Kadar Vitamin D pada Perempuan Usia Reproduksi Tidak Hamil dan Perempuan Hamil Trimester Pertama
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Objective: To compare vitamin D level in non-pregnantreproductive age women and first-trimester pregnant women.
Methods: This was acomparative cross-sectional study. The vitamin D serum level of two groups, the first one wasnon-pregnantreproductive age women (18-35 years), and the second one was first-trimester pregnant women,was collected. Samples were examined by Electro Chemiluminescence Immunoassay (ECLIA) method. The study was conducted in Dr. Hasan Sadikin Hospital in February-April 2018.
Results: The mean of vitamin D level in the non-pregnantreproductive age women group was 18.73 (6.93) ng/mL, while the first-trimester pregnant women group was 13.87 (4.04) ng/mL. The difference in mean of vitamin D level in both groups was significant with p-value<0.001.
Conclusion: Vitamin D level in the non-pregnantreproductive age women group is higher than the first-trimester pregnant women group.
Keywords: first-trimester pregnant women, non-pregnantreproductive-age women, vitamin D
Abstrak
Tujuan: Membandingkan kadar vitamin D pada perempuan usia reproduksi tidak hamil danperempuan hamil trimester pertama sehingga dapat mencegah berbagai komplikasi kehamilan.
Metode: Penelitian analitik komparatif potong lintang terhadap 60 perempuan yang dibagi menjadi 2 kelompok, kelompok perempuan usia reproduksi tidak hamil (18-35 tahun) dan kelompok perempuan hamil trimester pertama. Pada kedua kelompok dilakukan pemeriksaan kadar vitamin D dengan metode Electro-chemiluminescence immunoassay(ECLIA). Penelitian ini dilakukan di RSUP Dr. Hasan Sadikin pada bulan Februari-April 2018.Data diproses menggunakan program SPSS versi 24.0.
Hasil: Kadar vitamin D rata-rata pada kelompok perempuan usia reproduksi tidak hamil adalah 18,73 (6,93) ng/mL, sedangkan pada kelompok perempuan hamil trimester pertama adalah 13,87 (4,04) ng/mL. Perbedaan kadar rata-rata vitamin D pada kedua kelompok tersebut bermaka dengan nilai p<0,001.
Kesimpulan: Kadar vitamin D pada kelompok perempuan usia reproduksi tidak hamil lebih tinggi dibandingkan dengan kelompok perempuan hamil trimester pertama.
Kata kunci: perempuan hamil trimester pertama, perempuan usia reproduksi tidak hamil, vitamin