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Processus de l’aide médicale à mourir (AMM) chez la personne âgée en centre d’hébergement et de soins de longue durée (CHSLD) : étude qualitative descriptive de la perception des proches
Full text linkAnalyse des conceptions des élèves du secondaire quant à leurs choix d’orthographe des homophones
No full textL’étude des variables biomécaniques lors de la descente d’escaliers chez les personnes âgées ayant fait une chute
No full textLa détermination du code de déverrouillage des appareils mobiles à partir des traces digitales en contexte opérationnel
No full textExploration des facteurs sociétaux, organisationnels et individuels qui soutiennent ou entravent l'intégration socioprofessionnelle des personnes ayant une déficience auditive
No full text
Integration of Water Management Into the Energy Management Strategy for a Fuel Cell Vehicle
No full textUnlike other studies that focus solely on determining the optimal power distribution for a fuel cell hybrid electric vehicle (FC-HEV), this article aims to integrate water management into the energy management strategy (EMS) by designing an adaptive efficient purge strategy. This article investigates the impact of integrated water management into the EMS (IWM-EMS) on the performance and operating cost of FC-HEV. The IWM-EMS consists of two levels: the first level is the EMS, which determines the optimal power, and the second level is the proposed purge strategy. The proposed IWM-EMS in this article is the adaptive IWM-EMS (AIWM-EMS), which utilizes an adaptive efficient purge strategy that can adjust based on the fuel cell (FC) reference current. Another IWM-EMS is the nonadaptive IWM-EMS (NAIWM-EMS), which utilizes a constant purge strategy suggested by the FC manufacturer for all current levels. The results show that the FC-HEV under AIWM-EMS consumes 4.09% less hydrogen than the NAIWM-EMS and reduces total operating cost by up to 5.21%. In addition, 78.36% of the FCs’ operating time is spent in the high-efficiency zone
Soutenir l’inclusion scolaire d’élèves à besoins éducatifs particuliers en primaire quand on est néo-contractuel en France
No full textContemporary profiles and professional activities of French chiropractors: A national survey
No full textAbstract
Background
A comprehensive description of the profile of chiropractic practices and services provided can help guide curriculum design, inform quality improvement and guideline initiatives, and facilitate workforce planning. This cross-sectional study aimed to describe the sociodemographic characteristics, professional activities, work organization, clinical practice patterns, and interprofessional referrals of chiropractors in France.
Methods
A 37-item online questionnaire was administered between February and April 2023 to all registered chiropractors practicing or having a chiropractic-related professional activity in France, for whom an email address was available (n = 1067). We computed means and standard deviations for continuous variables and percentages for categorical variables. Representativeness of the results was estimated by comparing survey participants’ demographic information with members of the Association Française de Chiropraxie (AFC).
Results
The response rate was 46.4% (67.7% females; mean age = 34.9 ± 9.7 years), a sample comparable to AFC members. Most participants graduated in the past 15 years (81%) from the Institut Franco-Européen de Chiropraxie IFEC (94.5%). Just over one fifth of respondents had an additional university degree, and a similar proportion were involved in at least one chiropractic-related professional activity, mainly as lecturers in the IFEC or supervising clinicians in its outpatient clinics. Over half of the respondents (53.5%) had their main practice location in one of the four most populated regions in France, with 27.4% working in a multidisciplinary setting. Chiropractors reported regularly referring patients to general practitioners and physiotherapists, but less commonly received referrals. Middle-aged adults most commonly sought care, and spinal pain was the primary complaint reported by chiropractors. Chiropractors generally provided advice and education, manual therapy, and exercises. Two-thirds of respondents reported feeling moderate (30.6%) to intense or very intense (31.7%) competition with other manual therapy practitioners.
Conclusion
The French chiropractic workforce appears predominantly composed of female practitioners who graduated in the past 15 years. Practice patterns and continuing education choices suggest that evidence-based information is part of their practice. While chiropractors commonly reported referring patients to other care providers, fewer reported receiving referrals. Patients seeking chiropractic care were similar to those described in other countries
Triazenes as inhibitors of HIV-1 and HCoV-OC43: A structure-activity relationship study
No full textAbstract
Triazenes, or amino-substituted diazenes, are organic compounds containing three contiguous nitrogen atoms, that have potent biological activities. We previously demonstrated that triazenes, particularly those substituted with a phenyl or 3-pyridyl ring at the 1-position and a 2-pyridyl ring at the 3-position, exhibit anti-DENV properties. Here, we evaluated the antiviral activity against a betacoronavirus (HCoV-OC43) and a lentivirus (HIV-1). 1-(4-trifluoromethylphenyl)-2-imidazole-1-yldiazene (21) exhibited broad-spectrum activity (EC50 = 6.6–6.8 μM) but was cytotoxic to THP-1 cells. Pyridyl triazenes (14, 15) were the most potent against HCoV-OC43, while 1-(4-methoxyphenyl)-2-morpholin-4-yldiazene (6) and 1-(4-methoxyphenyl)3-(-6-methylpyridin-2-yl)triazene (10) inhibited HIV-1 the most. Structure–activity relationship analysis, supported by molecular docking, indicated that para-methoxy groups favored interactions with viral enzyme binding pockets, enhancing antiviral potency, while meta and para-trifluoromethyl groups were associated with reduced activity and increased cytotoxicity. These findings support the further development of triazenes as antiviral scaffolds