29295 research outputs found
Sort by
Efficacy, pharmacokinetic and pharmacodynamic evaluation of Apaziquone in the treatment of non- muscle invasive bladder cancer
No full textIntroduction: Apaziquone (also known as EO9 and Qapzola) is a prodrug that is activated to DNA damaging species by oxidoreductases (particularly NQO1) and has the ability to kill aerobic and/or hypoxic cancer cells.
Areas covered: Whilst its poor pharmacokinetic properties contributed to its failure in phase II clinical trials when administered intravenously, these properties were ideal for loco-regional therapies. Apaziquone demonstrated good anti-cancer activity against non-muscle invasive bladder cancer (NMIBC) when administered intravesically to marker lesions and was well tolerated with no systemic side effects. However, phase III clinical trials did not reach statistical significance for the primary endpoint of 2-year recurrence in apaziquone over placebo although improvements were observed. Post-hoc analysis of the combined study data did indicate a significant benefit for patients treated with apaziquone, especially when the instillation of apaziquone was given 30 minutes or more after surgery. A further phase III study is ongoing to test the hypotheses generated in the unsuccessful phase III studies conducted to date.
Expert opinion: Because of its specific pharmacological properties, Apaziquone is excellently suited for local therapy such as NMIBC. Future studies should include proper biomarkers
The social, legal and practice context for protecting and safeguarding children
No full textThis chapter explicates important themes in the development of child protection legislation. It begins by learning further from the history of a small number of child tragedies that help to illustrate how understanding of child protection as a social and relational phenomenon. The importance of trans-national conventions is then highlighted. Discussion consequently moves to brief consideration of examples of abusive practices by early years practitioners before consideration is given to the prevalence of child abuse for young children. The subsequent duties and responsibilities placed on early years practitioners by legislation and the conditions necessary for effective practice with parents and carers are covered
Safeguarding and Protecting Children in the Early Years, 2nd edition
No full textThis second edition provides a comprehensive guide to safeguarding and child protection in the early years. Aimed at both students and practitioners, it offers clear insight and guidance into the legal and policy foundations for effective safeguarding practice, together with both the historical context and also more contemporary developments in safeguarding practice in the early years sector.
This new edition has been fully updated to reflect current legislation and includes new material on interagency work, supporting children’s resilience and safeguardingall children. Drawing on the everyday dilemmas and experiences of early years professionals, it helps you to find solutions to both practical and moral issues in a context of legal duties and responsibilities. The chapters consider:
•the historical context of safeguarding and child protection;
•the legislative framework around safeguarding and child protection;
•safeguarding through inter-professional and multidisciplinary work;
•the identification of neglect in early years children;
•the consequential abuse that can occur as a result of parental behaviours;
•safeguarding children’s health and wellbeing;
•safeguarding as a member of a team, and the importance of communication; and
•safeguarding against the misuse of technology.
This text has been written by a multidisciplinary team of academics from a breadth of UK Universities, with a wealth of experience in safeguarding and child protection, the EYFS, health visiting, social work, the police, and in leading and managing services for children and families. This second edition is essential reading for anyone aspiring to, or working with children in the early years
Towards an Understanding of Microservices
No full textMicroservices architectures are a departure from traditional Service Oriented Architecture (SOA). Influenced by Domain Driven Design (DDD), microservices architectures aim to help business analysts and enterprise architects develop scalable applications that embody flexibility for new functionalities as businesses develop, such as scenarios in the Internet of Things (IoT) domain. This article compares microservices architecture with SOA and identifies key characteristics that will assist application designers to select the most appropriate approach.
Urban spaces’ commoning and its impact on planning: a case study of the former Slaughterhouse Exchange Building in Milan
No full textThanks to several foundational contributions (De Angelis 2010; Hardt and Negri 2009; Harvey 2012; Ostrom 1990), the topic of urban commons has recently gained much interest, as indicated by a number of publications and international conferences (Dellenbaugh et al., 2015). While these have variously analysed the topic in relationship to its fundamental elements, this paper further investigates the relationship between urban commons and planning and local governance processes (Muller 2015). On 5 May 2012, the artists’ collective M^C^O (henceforth Macao) drew public attention to the massive number of unused and vacant spaces in Milan by squatting in the iconic Galfa Tower, a private property that had been abandoned since 1996. This event, recalling ideals and actions of the social centres that flourished during the 1980s and 1990s in Italy, represented the first public manifestation of the complex and hidden scenarios of the social movements animating the cultural life of Milan. Due to their intimate awareness of urban spaces (Molinari 2012), these artist-led informal initiatives have been able to stand opposite to globally oriented political choices and could thus be interpreted as symbols of community values and local resistance. Symbolically, squatting in the Galfa Tower served to shine a light on the need for a radical change in urban policies regarding the reuse of the massive patrimony of abandoned sites in towns, which could accommodate un-revealed spatial and social needs (Valli 2015).
Unlike the current planning tools and practices adopted by the City Council of Milan (Oliva 2001), Macao’s activists developed and proposed the Constituent City manifesto (Macao 2015), which sought to guarantee that vacant and abandoned properties within metropolitan Milan, whether privately or publicly owned, could be directly managed by self-organised groups of citizens. In their alternative proposal, the Macao activists were striving for the possibility for these self-organised communities to manage the available spaces for non-profit purposes through public assemblies.
Starting from these premises, the paper interrogates the issue of how urban commoning can challenge conventional planning procedures. Using a case study of the former Slaughterhouse Exchange Building (henceforth SEB) in Milan, also squatted in the by Macao movement, the paper seeks to identify the mutual influences between commoning practices, local governance and planning policies.
Drawing on these insights, we conclude by offering a reflection on the roles that commoning practices may have in defining innovative governance and planning processes
Two challenges for critical studies on men and masculinities: The hegemony of men, and trans(national)patriarchies
No full textThis article provides a brief overview of Critical Studies on Men and Masculinities (CSMM), a broad sub-field of Feminist Studies, Gender Studies, and Women's Studies, and some of the tensions and contradictory processes there. The main body of the article explores two major contemporary challenges for CSMM. The first concerns the conceptual and political move from masculinities, and hegemonic masculinity, to the hegemony of men. The second addresses the move from the ethnographic moment to global and transnational processes, and specifically the transformations of patriarchy from the local and the national to the transnational, as summed up in the term trans(national)patriarchies. Characteristics features of such transpatriarchies are examined. Challenging both the relations of men and masculinities and the relations of local and transnational patriarchies are key tasks for CSMM
Making an Arsonist: A Psychological Approach to Understanding Expressive Arson
No full textThe offence of arson comes under the category of property crime, although the serious consequences of the offence often have a huge impact on both people and public costs, with serious injury and death potential outcomes. As with many crimes, there are various motivations that may behind a person committing arson. These can be understood under whether the offence was instrumental and therefore carrying out the crime for personal gain, or expressive, carrying out the offence due to difficulty in expressing their emotions. Instrumental arsonists may be easier to detect due to an often obvious financial or personal motivation, and these offenders are generally more common within the population of arsonists. However, perhaps more important to explore in relation to where psychology can best aid understanding and inform practice, is in cases where there is little or no instrumental value. These expressive arsonists are significantly more likely to reoffend than their instrumental counterparts, adding further to the need to gain a greater understanding of the factors that play a role in such individuals’ trajectories. The present paper reviews the
current literature surrounding expressive arson to present a more comprehensive understanding of the factors that contribute to this deviant behaviour. In doing so, the present paper draws on explanations from developmental, psychopathological and personality psychology to critically form such an understanding and present this in an understandable way that possesses heuristic value for the
psychological community with an interest in this area
Tandem Aryne-Capture/Sigmatropic Rearrangement as a Metal-Free Entry to Functionalized N -Aryl Pyrrolidines
No full textWe report a new method for the synthesis of novel N-aryl proline analogues. By reacting an aryne precursor with N-(2-malonyl) tetrahydropyridines in the presence of tetrabutylammonium fluoride (TBAF), a tandem aryne-capture/anion isomerisation/[2,3]-sigmatropic rearrangement is induced, leading to good yields of 3-substituted N-aryl-2-acylpyrrolidines. These products are known subunits of biological probes, sensors and drug-like fragments, and are not easily accessed directly by other methods. The reaction is also notable as the first [2,3]-rearrangement of cyclic ammonium ylides at room temperature
Access Repository Dashboard
Do you manage University of Huddersfield Repository? Access insider analytics, issue reports and manage access to outputs from your repository in the CORE Repository Dashboard!