Mediamusic (E-Journal)
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The Fornax Deep Survey (FDS) with the VST. XI. The search for signs of preprocessing between the Fornax main cluster and Fornax A group
No full textContext. Galaxies either live in a cluster, a group, or in a field environment. In the hierarchical framework, the group environment bridges the field to the cluster environment, as field galaxies form groups before aggregating into clusters. In principle, environmental mechanisms, such as galaxy-galaxy interactions, can be more efficient in groups than in clusters due to lower velocity dispersion, which lead to changes in the properties of galaxies. This change in properties for group galaxies before entering the cluster environment is known as preprocessing. Whilst cluster and field galaxies are well studied, the extent to which galaxies become preprocessed in the group environment is unclear. Aims: We investigate the structural properties of cluster and group galaxies by studying the Fornax main cluster and the infalling Fornax A group, exploring the effects of galaxy preprocessing in this showcase example. Additionally, we compare the structural complexity of Fornax galaxies to those in the Virgo cluster and in the field. Methods: Our sample consists of 582 galaxies from the Fornax main cluster and Fornax A group. We quantified the light distributions of each galaxy based on a combination of aperture photometry, Sérsic+PSF (point spread function) and multi-component decompositions, and non-parametric measures of morphology. From these analyses, we derived the galaxy colours, structural parameters, non-parametric morphological indices (Concentration C; Asymmetry A, Clumpiness S; Gini G; second order moment of light M20), and structural complexity based on multi-component decompositions. These quantities were then compared between the Fornax main cluster and Fornax A group. The structural complexity of Fornax galaxies were also compared to those in Virgo and in the field. Results: We find significant (Kolmogorov-Smirnov test p-value < α = 0.05) differences in the distributions of quantities derived from Sérsic profiles (g′‒r′, r′‒i′, Re, and μ̄e,r′), and non-parametric indices (A and S) between the Fornax main cluster and Fornax A group. Fornax A group galaxies are typically bluer, smaller, brighter, and more asymmetric and clumpy. Moreover, we find significant cluster-centric trends with r′‒i′, Re, and μ̄e,r′, as well as A, S, G, and M20 for galaxies in the Fornax main cluster. This implies that galaxies falling towards the centre of the Fornax main cluster become fainter, more extended, and generally smoother in their light distribution. Conversely, we do not find significant group-centric trends for Fornax A group galaxies. We find the structural complexity of galaxies (in terms of the number of components required to fit a galaxy) to increase as a function of the absolute r′-band magnitude (and stellar mass), with the largest change occurring between ‒14 mag ≲Mr′ ≲ ‒19 mag (7.5 ≲ log10(M*/M⊙) ≲ 9.7). This same trend was found in galaxy samples from the Virgo cluster and in the field, which suggests that the formation or maintenance of morphological structures (e.g., bulges, bar) are largely due to the stellar mass of the galaxies, rather than the environment they reside in. Full Tables 2, 3, and I.1 are only available at the CDS via anonymous ftp to cdsarc.u-strasbg.fr (ftp://130.79.128.5) or via http://cdsarc.u-strasbg.fr/viz-bin/cat/J/A+A/647/A10
Investigating Data-driven Biological Subtypes of Psychiatric Disorders Using Specification-Curve Analysis - ERRATUM
No full textTranslational insights from single-cell technologies across the cardiovascular disease continuum
No full textCardiovascular disease is the leading cause of death worldwide. The societal health burden it represents can be reduced by taking preventive measures and developing more effective therapies. Reaching these goals, however, requires a better understanding of the pathophysiological processes leading to and occurring in the diseased heart. In the last 5 years, several biological advances applying single-cell technologies have enabled researchers to study cardiovascular diseases with unprecedented resolution. This has produced many new insights into how specific cell types change their gene expression level, activation status and potential cellular interactions with the development of cardiovascular disease, but a comprehensive overview of the clinical implications of these findings is lacking. In this review, we summarize and discuss these recent advances and the promise of single-cell technologies from a translational perspective across the cardiovascular disease continuum, covering both animal and human studies, and explore the future directions of the field.</p
Long-term outcomes after endoscopic treatment for Barrett's neoplasia with radiofrequency ablation +/- endoscopic resection:results from the national Dutch database in a 10-year period
No full textOBJECTIVE: Radiofrequency ablation (RFA)±endoscopic resection (ER) is the preferred treatment for early neoplasia in Barrett's oesophagus (BE). We aimed to report short-term and long-term outcomes for all 1384 patients treated in the Netherlands (NL) from 2008 to 2018, with uniform treatment and follow-up (FU) in a centralised setting.DESIGN: Endoscopic therapy for early BE neoplasia in NL is centralised in nine expert centres with specifically trained endoscopists and pathologists that adhere to a joint protocol. Prospectively collected data are registered in a uniform database. Patients with low/high-grade dysplasia or low-risk cancer, were treated by ER of visible lesions followed by trimonthly RFA sessions of any residual BE until complete eradication of BE (CE-BE). Patients with ER alone were not included.RESULTS: After ER (62% of cases; 43% low-risk cancers) and median 1 circumferential and 2 focal RFA (p25-p75 0-1; 1-2) per patient, CE-BE was achieved in 94% (1270/1348). Adverse events occurred in 21% (268/1386), most commonly oesophageal stenosis (15%), all were managed endoscopically. A total of 1154 patients with CE-BE were analysed for long-term outcomes. During median 43 months (22-69) and 4 endoscopies (1-5), 38 patients developed dysplastic recurrence (3%, annual recurrence risk 1%), all were detected as endoscopically visible abnormalities. Random biopsies from a normal appearing cardia showed intestinal metaplasia (IM) in 14% and neoplasia in 0%. A finding of IM in the cardia was reproduced during further FU in only 33%, none progressed to neoplasia. Frequent FU visits in the first year of FU were not associated with recurrence risk.CONCLUSION: In a setting of centralised care, RFA±ER is effective for eradication of Barrett's related neoplasia and has remarkably low rates of dysplastic recurrence. Our data support more lenient FU intervals, with emphasis on careful endoscopic inspection. Random biopsies from neosquamous epithelium and cardia are of questionable value.NETHERLANDS TRIAL REGISTER NUMBER: NL7039.</p
Fairness Perceptions of the Division of Household Labor:Housework and Childcare
No full textAn unequal division of housework has been found to be often regarded as fair, which may explain why women still do most household labor. This study extends previous research by also investigating childcare-an increasingly important part of household labor, which is likely to have a different meaning than housework. It examines how perceptions of fairness for both housework and childcare are influenced by the division of housework, childcare, and paid labor, and whether patterns differ by gender. Data from the Netherlands (men: N = 462; women: N = 638) show that unequal divisions of housework, and especially childcare, are often perceived as fair. When it comes to how an increasingly unequal household labor division is related to unfairness, associations are stronger for women than for men. Fairness of the household labor division is evaluated in relation to total workload and not in isolation from other types of labor.</p
The ethnic identity of transracially placed foster children with an ethnic minority background:A systematic literature review
No full textBackgroundEthnic minority foster children are frequently placed in families with ethnic majority backgrounds. In the international literature these placements are most commonly called transracial placements.AimsWith this study, we aim to obtain an encompassing view of the empirical scientific literature on how transracial placements may affect the ethnic identity of foster children.Materials and methodsTo gain insight into the ethnic identity of transracially placed foster children and the way they are ethnically socialized, we conducted a systematic literature review. We thereby followed the guidelines of the PRISMA statement.ResultsTransracially placed foster children may experience higher fluctuations in their racial/ ethnic identity over time than adolescents with a minority background in the general population. They also seem to be prone to experience disconnection from, or on the contrary, connection with the birth network; and some transracially placed foster children struggle with societal messages they receive about minority ethnicity and race. They may have an increased awareness of their minority ethnic background because of different physical appearances between themselves and the foster family. Foster parents can play a pivotal role in these processes, since culturally competent foster parents may guide foster children in their ethnic identity development by being open towards children’s cultural minority background as well as being self‐reflective regarding their own cultural values and beliefs.DiscussionThe ethnic development of transracially placed foster children seems to be influenced by intersecting mechanisms of being in foster care and having a minority ethnicity. Although the selected articles assume that foster parents impact the ethnic identities of their ethnic minority foster children, none of them measured the impact of foster parents’ skills and knowledge on foster children’ s ethnic identity development directly.ConclusionBeing transracially placed impacts the ethnic identity of foster children. Foster parents need to be cultural competent to encourage their foster children’s ethnic identity development
The Role of Domestic Courts in the Interpretation of Customary International Law:How can we Learn from Domestic Interpretive Practices?
No full textThis chapter examines the contribution that domestic courts may have in the development of rules or guidelines for the interpretation of customary international law (CIL). Through an examination of national cases where courts interpret both domestic and international custom, the chapter traces methodologies of interpretation and motivations behind them. The chapter then asks two questions: how can we learn from domestic interpretive practices? and why should we learn from them? In answer to the first question, the chapter argues that domestic courts can contribute to the development of rules for CIL interpretation beyond the role assigned to them in the framework of sources, and also in informal ways. In answer to the second question, the chapter argues that looking to domestic interpretive approaches for custom may help us fill the ‘gap’ currently existing on this issue in international law, that domestic courts offer a wealth of cases from which we can draw, and that by learning from domestic interpretive practices international law can provide domestic judges with various familiar tools for their further engagement with CIL in the future
Vitamin D levels in children and adolescents with chronic tic disorders:a multicentre study
No full textThis study investigated whether vitamin D is associated with the presence or severity of chronic tic disorders and their psychiatric comorbidities. This cross-sectional study compared serum 25-hydroxyvitamin D [25(OH)D] (ng/ml) levels among three groups: children and adolescents (3-16 years) with CTD (n = 327); first-degree relatives (3-10 years) of individuals with CTD who were assessed for a period of up to 7 years for possible onset of tics and developed tics within this period (n = 31); and first-degree relatives who did not develop tics and were ≥ 10 years old at their last assessment (n = 93). The relationship between 25(OH)D and the presence and severity of tics, as well as comorbid obsessive-compulsive disorder (OCD) and attention-deficit/hyperactivity disorder (ADHD), were analysed controlling for age, sex, season, centre, latitude, family relatedness, and comorbidities. When comparing the CTD cohort to the unaffected cohort, the observed result was contrary to the one expected: a 10 ng/ml increase in 25(OH)D was associated with higher odds of having CTD (OR 2.08, 95% CI 1.27-3.42, p < 0.01). There was no association between 25(OH)D and tic severity. However, a 10 ng/ml increase in 25(OH)D was associated with lower odds of having comorbid ADHD within the CTD cohort (OR 0.55, 95% CI 0.36-0.84, p = 0.01) and was inversely associated with ADHD symptom severity (β = - 2.52, 95% CI - 4.16-0.88, p < 0.01). In conclusion, lower vitamin D levels were not associated with a higher presence or severity of tics but were associated with the presence and severity of comorbid ADHD in children and adolescents with CTD.</p
Crafting Survey Research:A Systematic Process for Conducting Survey Research
No full textSurveys represent flexible and powerful ways for practitioners to gain insights into customers and markets and for researchers to develop, test, and generalize theories. However, conducting effective survey research is challenging. Survey researchers must induce participation by “over-surveyed” respondents, choose appropriately from among numerous design alternatives, and need to account for the respondents’ complex psychological processes when answering the survey. The aim of this chapter is to guide investigators in effective design of their surveys. We discuss state-of-the-art research findings on measurement biases (i.e., common method bias, key informant bias, social desirability bias, and response patterns) and representation biases (i.e., non-sampling bias and non-response bias) and outline when those biases are likely to occur and how investigators can best avoid them. In addition, we offer a systematic approach for crafting surveys. We discuss key steps and decisions in the survey design process, with a particular focus on standardized questionnaires, and we emphasize how those choices can help alleviate potential biases. Finally, we discuss how investigators can address potential endogeneity concerns in surveys
