Journal of Patan Academy of Health Sciences
Not a member yet
134332 research outputs found
Sort by
Study of heart rate variability test in prediabetes, prehypertension and co-existing prediabetes with prehypertension subjects
Get PDFIntroduction: Cardiac autonomic neuropathy is common in people with diabetes and hypertension and increases the risk of heart disease. Heart rate variability (HRV) is a reliable method to assess cardiac autonomic function. However, limited information exists about HRV changes before these conditions develop. This study aimed to assess HRV changes in individuals with prediabetes, prehypertension, and both conditions together.
Method: A comparative cross-sectional study was conducted on 120 participants (both sexes, mean age 40.24±7.34 years) after ethical approval. Participants were categorized into four groups (n=30 each): control, prediabetes, prehypertension, and coexisting prediabetes with prehypertension, based on HbA1c and blood pressure measured on two occasions. HRV was recorded for 5 minutes in the sitting position using the Polar H10 device, and time- and frequency-domain parameters were analyzed and compared with controls.
Result: Total Power was significantly lower in the coexisting group and prehypertensive group compared to controls (p<0.001). Time-domain indices- RMSSD, NN50, pNN50, and SDNN were also markedly reduced in the coexisting and prehypertensive groups compared to controls (p<0.001 for all). The mean RR interval was shorter in the coexisting group (p<0.001), indicating a higher resting heart rate. Maximum and minimum heart rates were also significantly higher (p = 0.032 and 0.002, respectively). HRV parameters showed no significant difference between the prediabetes and control groups.
Conclusion: HRV was lowest in the coexisting group, moderately reduced in prehypertension, and unchanged in prediabetes. Coexistence of prediabetes and prehypertension causes greater autonomic dysfunction, highlighting the importance of early detection and prevention
Association of maxillary sinus volume and deviated nasal septum (DNS) assessed by computed tomography (CT) in patients with chronic maxillary sinusitis in tertiary care hospital of Nepal.
Get PDFIntroduction: Deviated nasal septum (DNS) is a common anatomical variation frequently associated with chronic maxillary rhinosinusitis (CRS). Changes in nasal airflow dynamics due to DNS can alter sinus ventilation and muco-ciliary drainage, potentially affecting maxillary sinus volume. Radiological assessment, particularly computed tomography (CT), plays a vital role in evaluating sinonasal anatomy and pathology.
Method: This cross-sectional, prospective study was done in Department of Radiology, Patan Hospital, among patients diagnosed with CRS who underwent paranasal sinus (PNS) CT scans. MSV were measured using CT imaging software, and the presence and severity of DNS were documented. Statistical analysis was performed using SPSS v 20.
Result: Among the patients, 237 (78.2%) had DNS, predominantly on the right side (54.0%). The mean MSV was significantly smaller on the deviated side (13.21±2.98 cm³) compared to the contralateral side (14.56±3.15 cm³, p<0.001). Increasing DNS severity was associated with progressive reduction in MSV (mild: 0.58 ± 0.61 cm³; moderate: 1.63±0.85 cm³; severe: 3.07±1.22 cm³; p<0.001). A strong negative correlation was found between deviation angle and ipsilateral MSV (r=–0.62, p<0.001). Mucosal thickening occurred in 84.2% of patients, mainly on the deviated side (62.4%, p=0.002), and was more frequent in moderate-to-severe deviations. Pyramidal sinus morphology predominated, with no significant right–left differences in patients without DNS
Conclusion: DNS significantly reduces ipsilateral sinus volume and increases mucosal changes. CT-based volumetric evaluation and septal assessment are vital for CRS diagnosis and surgical planning
Data from the ARDA National Profiles, 2005 Update - Religion Indexes, Adherents and Other Data
No full text
National Longitudinal Study of Adolescent to Adult Health, Public Use Children and Parenting Data, Wave III
No full text
Library Instruction
No full textSessions targeted to students and researchers of all levels (but mainly to undergraduate and graduate students) to increase working efficiency and ability to find appropriate information