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Understanding the Determinants of Blockchain Adoption: An Empirical Study
Get PDFBlockchain technology (BT) has the potential to enhance security and robustness of transactions through a distributed ledger bookkeeping process. This study employs technology-organization-environment (TOE) framework and threat-rigidity theory (TRT) to examine whether perceived disruption caused by COVID-19 pandemic significantly impacted the adoption of BT, and inclination to adopt BT in the US. The COVID-19 pandemic provided a unique backdrop, as it affected businesses across all industries, sizes, and geographies. Results show a non-significant effect of perceived pandemic disruption on the current stage of BT adoption and intention to adopt BT. However, disruption readiness positively influences the current stage of BT adoption and intention to adopt BT. While the complexity of BT does not significantly influence the level of adoption, it negatively impacts the intention to adopt BT. The study provides insights into key factors that managers need to focus on to accelerate the adoption of BT
Sense of belonging of bachelor nursing students: a descriptive-comparative study
No full textackground: A sense of belonging, defined as acceptance, inclusion, and identity within a group, significantlyinfluences nursing students’ academic and social integration into college. Limited belonging causes studentattrition.Aim: This research explored factors influencing nursing students’ sense of belonging and identified elementspromoting or hindering this feeling.Methods: This is a cross-sectional, descriptive comparative study that was conducted with undergraduatenursing students (N = 201) from multiple campuses at a southwestern U.S. university. Data were collectedvia an anonymous survey using the Department Sense of Belonging and Involvement (DeSBI) tool. Descrip-tive and comparative statistics were analyzed.Results: Campus location significantly influenced students’ sense of belonging. Satellite campus studentsreported significantly higher belonging than main campus students.Conclusions: Campus location has a significant impact on nursing students’ sense of belonging, with studentsfrom satellite campuses reporting higher levels of inclusion and connection. These findings highlight theneed for targeted institutional interventions at main campuses to cultivate a stronger sense of community.Enhancing the sense of belonging on main campuses may contribute to improved academic performance,reduced attrition, and a more resilient nursing workforce
Natalie Collins
Get PDFIn this recording, Natalie Collins is the guest being interviewed by her adult child. She is asked about her life living in Southern California, to which she talks about being in a large family and how schools were segregated and integrated. She also speaks about the dairy farm her family had, which was run by her father to support his family. She then talks about how her parents separated and explains how living between parents changed the way she and her siblings attended school. After a brief discussion of how her mother preferred ice boxes to fridges and the friends from her childhood, Collins talks about going to churches different in denominations and then about the racism in her time. In her own words, Collins never experienced racism in extreme events other than being called names, rarely, and segregation in the movie theater. However, her father was very much active in that discussion for racial equality. Once she was older, Collins explains she worked in house cleaning and looking after children and later attended college. She went to Tuskegee University to study business and, after coming home, married her future husband, the father of the interviewer. The recording ends with a discussion of her wedding in Las Vegas
IMPLEMENTING A SUSTAINABLE ANTIMICROBIAL RESISTANCE SURVEILLANCE ACROSS RIVERSIDE COUNTY
Get PDFThis project focuses on improving health surveillance in remote communities, addressing antimicrobial resistance (AMR) enhancing connectivity and data collection. Geographic barriers, high shipping costs, and logistical challenges have historically hindered healthcare delivery in underserved areas. By integrating healthcare facilities into a cohesive surveillance systems, would improve specimen collection and data analysis. A systematic review of literature identified key strategies, including governmental support, strengthening laboratory capacity, addressing logistical barriers, and enhancing connectivity. Notable results include insights to integrate new facilities when creating a surveillance network, supported by training and state-funded resources. Actionable steps, such as implementing National Action Plans, establishing National Reference Laboratories, and developing Laboratory Information Management Systems (LIMS), have improved data reliability and facilitated proactive health responses. The project anticipates generating valuable information to inform public health policies, increasing awareness, and bridging healthcare gaps. By addressing logistical barriers and empowering local facilities, it provides a replicable model for improving healthcare delivery in vulnerable populations
Are Emojis the New Words? A Sentiment Analysis of Social Media Brand Conversations
Get PDFEmojis have become an increasingly important aspect of consumer-brand interactions in the Indian subcontinent. However, the impact of emoji use on brand image and mental health remains underexplored, particularly in emerging economies like India, where structured research on this topic is limited. To address this gap, the present study analyzes over 4,600 consumer tweets related to 19 prominent brands across eleven industries. Using VADER sentiment analysis, the research develops a metric to assess consumer sentiment and brand engagement in relation to emoji usage. The findings indicate that effective integration of emojis contributes to positive consumer sentiment and enhanced brand engagement. Given that emojis have become a fundamental part of everyday communication, this study recommends that brand and marketing managers closely monitor consumer interactions with emojis, utilizing rich data to refine communication strategies and maximize emoji-driven engagement
The Development of MAGMAS Inhibition as a Potential Therapeutic Target in Temozolomide Resistant Glioma
Get PDFGlioblastoma (GBM) is a highly aggressive brain tumor that remains a significant challenge in neuro-oncology today. Approximately 90% of GBM patients experience tumor recurrence within one to two years of diagnosis. Therefore, due to its high resistance to conventional therapies, new treatment strategies are urgently needed. The current standard of care for GBM is the chemotherapeutic Temozolomide (TMZ). TMZ is an oral alkylating agent, it functions by delivering a methyl group to purine bases. The development of resistance to TMZ is partially regulated by the DNA repair enzyme O6- methylguanine-DNA methyltransferase (MGMT). Despite the potential shown by MGMT promoter methylation in enhancing patient survival, recent studies have revealed its low predictive value in GBM patients. MGMT hypermethylation often leads to resistance by activating DNA repair pathways. Glioma stem cells (GSCs) contribute to chemoresistance and tumor heterogeneity due to their self-renewal capacity and activation of DNA repair responses to overcome radiation and TMZ treatment. These resistance defenses contribute to tumor recurrence and highlight a need for potential therapies in GBM.
MAGMAS, a 13.8 kDa mitochondria trafficking protein, regulates the ATP stimulatory activity of mitochondrial import inner membrane translocase subunit Tim14 on mtHSP70 and oxidative phosphorylation via interactions with the respiratory complexes in the inner mitochondrial membrane. Previously, our lab has demonstrated that MAGMAS is overexpressed in GBM patients\u27 tissues and mouse xenografts. Furthermore, the pharmacological inhibition of MAGMAS through the novel compound, BT9, has been shown to promote cytotoxicity and impair respiratory functions in malignant glioma cells, underscoring its therapeutic potential in GBM. However, further studies are needed to fully understand the role of MAGMAS, from initial tumor progression to its implication in the development of treatment resistance.
Our study\u27s main objective is to understand the role of MAGMAS in the development of TMZ resistance. Our preliminary data, comparing temozolomide- resistant (TR) GBM cell lines, U251-TR and D54 MG-TR, with their drug- sensitive parental cell lines (S), shows a significant upregulation of MAGMAS in the TR cell lines compared to the S lines. To study alternative DNA repair mechanisms and their contribution to chemoresistance, we incorporated an additional clinically relevant model, cell lines resistant to TMZ in presence of O6- benzylguanine (O6-BG, MGMT inhibitor), OTR lines. Since O6-MG inhibits MGMT, OTR cell lines acquire TMZ resistance through alternative DNA repair pathways. MAGMAS mRNA expression is significantly higher in both TR and OTR in comparison to S cells. This observation led to our hypothesis that MAGMAS inhibition could potentially re-sensitize TR and OTR GBM cell lines to TMZ. Our findings support this hypothesis, as we demonstrate that MAGMAS pharmacological inhibition, using BT9, sensitizes chemoresistant cell lines, TR and OTR, to TMZ. These results suggest that a combination therapy based on MAGMAS inhibition and TMZ might offer an increased benefit when used in combination to treat TMZ-resistant GBM
USING THE DASH DIET TO CREATE HYPERTENSIVE-FRIENDLY DISHES FOR PEOPLE OF CHINESE HERITAGE
Get PDFCardiovascular disease is the leading cause of death worldwide, associated with high sodium intake being a primary contributor to elevated blood pressure. The US Dietary Guidelines for sodium intake is 2,300 mg per day; however, studies indicate that the average daily sodium consumption among Chinese adults is 5,013 mg. The Dietary Approaches to Stop Hypertension (DASH) diet is often recommended to those diagnosed with hypertension. This project aims to develop a cookbook featuring lower-sodium Chinese recipes following the DASH diet guidelines. Twenty-five traditional Chinese recipes were modified to align with DASH diet guidelines (25% reduction in sodium content). Nutrient analysis software was employed to evaluate the sodium content of the original and modified recipes. Twenty-five participants were recruited through direct recruitment and word of mouth. The participants will complete two online surveys. The first survey was conducted to gather insight into participants’ eating habits, preferences, and cooking skills related to the preparation of Chinese food. The second survey was to have participants evaluate the recipes and the dishes prepared for their visual appeal, taste, portion size, and overall satisfaction with the dish. Recipe development was guided by feedback from three different taste testing sessions involving over 180 responses from Chinese American individuals and nutrition students. Participants evaluated the recipes based on their visual appeal, taste, clarity, and ease of preparation. Common feedback highlighted the need for a stronger umami flavor (due to reduced sodium), which called for adding alternative seasonings such as herbs, spices, and flavorful vegetables. The final product is a heart-healthy resource for those with hypertension and are struggling to create flavorful, low-sodium Chinese meals at home