6289 research outputs found
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Physical Activity Programming to Improve QoL in Pediatric IBD Patients
Get PDFDiscussion: This work contributes to limited literature supporting the positive impact of PA in a target population and provides novel guidelines to implement an accessible PA program proven to be effective and well-liked by patients & families. Findings support incorporation of PA into the holistic care of pediatric patients with IBD.https://knowledgeconnection.mainehealth.org/lambrew-retreat-2025/1037/thumbnail.jp
Do Hospitalized Patients\u27 Quality of Life benefit from Alternative Lighting Practices?
Get PDFPICOT Question: In hospitalized patients, does exposure to alternative lighting interventions, as opposed to standard lighting practices, improve quality of life and/or recovery outcomes during their hospital stay?https://knowledgeconnection.mainehealth.org/nurseresidency/1122/thumbnail.jp
Well Water Contamination: Lessons Learned Over the Past Three Decades
No full textCME available for 1 year after presentation
CME Text Code: 97034
In order to claim CME credit, please complete an evaluation in CloudCME for each presentation.https://knowledgeconnection.mainehealth.org/pediatrics_gr/1080/thumbnail.jp
The History of the MaineHealth Institute for Research
Get PDFhttps://knowledgeconnection.mainehealth.org/histories/1013/thumbnail.jp
Associations between COVID-19 therapies and outcomes in rural and urban America: A multisite, temporal analysis from the Alpha to Omicron SARS-CoV-2 variants
No full textPURPOSE: To investigate the enduring disparities in adverse COVID-19 events between urban and rural communities in the United States, focusing on the effects of SARS-CoV-2 vaccination and therapeutic advances on patient outcomes. METHODS: Using National COVID Cohort Collaborative (N3C) data from 2021 to 2023, this retrospective cohort study examined COVID-19 hospitalization, inpatient death, and other adverse events. Populations were categorized into urban, urban-adjacent rural (UAR), and nonurban-adjacent rural (NAR). Adjustments included demographics, variant-dominant waves, comorbidities, region, and SARS-CoV-2 treatment and vaccination. Statistical methods included Kaplan-Meier survival estimates, multivariable logistic, and Cox regression. FINDINGS: The study included 3,018,646 patients, with rural residents constituting 506,204. These rural dwellers were older, had more comorbidities, and were less vaccinated than their urban counterparts. Adjusted analyses revealed higher hospitalization odds in UAR and NAR (aOR 1.07 [1.05-1.08] and 1.06 [1.03-1.08]), greater inpatient death hazard (aHR 1.30 [1.26-1.35] UAR and 1.37 [1.30-1.45] NAR), and greater risk of other adverse events compared to urban dwellers. Delta increased, while Omicron decreased, inpatient adverse events relative to pre-Delta, with rural disparities persisting throughout. Treatment effectiveness and vaccination were similarly protective across all cohorts, but dexamethasone post-ventilation was effective only in urban areas. Nirmatrelvir/ritonavir and molnupiravir better protected rural residents against hospitalization. CONCLUSIONS: Despite advancements in treatment and vaccinations, disparities in adverse COVID-19 outcomes persist between urban and rural communities. The effectiveness of some therapeutic agents appears to vary based on rurality, suggesting a nuanced relationship between treatment and geographic location while highlighting the need for targeted rural health care strategies
Interventions to Boost Child Development
No full textCME available for 1 year after presentation
CME Text Code: 97006
In order to claim CME credit, please complete an evaluation in CloudCME for each presentation.https://knowledgeconnection.mainehealth.org/pediatrics_gr/1064/thumbnail.jp
Cross-titration from risperidone to clozapine utilizing clozapine serum concentrations: A case report
No full textINTRODUCTION: Clozapine and risperidone are second-generation antipsychotics used in the treatment of schizophrenia. There are no guidelines on cross-titration of antipsychotics and, additionally, there is a paucity of published data to support the potential utility of using serum drug levels to guide dosing in these situations. CASE REPORT: A 68-year-old female patient with a history of schizophrenia, taking risperidone and fluoxetine, and a recent diagnosis of Parkinson\u27s disease was admitted to the hospital after a fall at home. During the patient\u27s hospital stay, utilizing serum clozapine levels as guidance, the patient was cross-titrated from risperidone 12 mg daily to a final dose of clozapine 75 mg daily over the span of 17 days, in the setting of multiple possible drug-drug interactions. DISCUSSION: There is no evidence-based guidance on transitioning patients from one antipsychotic to another especially in the setting of drug-drug interactions. In this case, the patient was successfully transitioned from risperidone to clozapine using serum clozapine levels and clinical status to guide decision-making. CONCLUSIONS: Utilizing serum clozapine levels may be helpful in guiding dose changes during antipsychotic cross-titration, especially when multiple drug interactions are involved
February 26th, 2025: Point-of-Care Ultrasound: An Opportunity for Healthcare Innovation to Bridge Medical Education & Patient Care
No full texthttps://knowledgeconnection.mainehealth.org/medicine_gr/1036/thumbnail.jp
A Tale of Two Burdens: Chronic Illness and Mental Health in Pediatrics
No full textCME available for 1 year after presentation
CME Text Code: 97036
In order to claim CME credit, please complete an evaluation in CloudCME for each presentation.https://knowledgeconnection.mainehealth.org/pediatrics_gr/1082/thumbnail.jp