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Prioritization of novel agents for further investigation in pediatric non-rhabdomyosarcoma soft tissue sarcomas: A report from the Children\u27s Oncology Group
No full textNon-rhabdomyosarcoma soft tissue sarcoma (NRSTS) is a group of over 70 tumors that occur across the age range and account for approximately 4 % of childhood cancers. Patients with metastatic or relapsed NRSTS have a dismal prognosis. The histologic, molecular, and clinical heterogeneity of NRSTS and the rarity of individual types pose unique challenges to the study of these diseases. The Children\u27s Oncology Group (COG) Soft Tissue Sarcoma (STS) Committee established a NRSTS Novel Agents Working Group to identify and prioritize agents for further study in pediatric NRSTS, similar to recent efforts in Ewing sarcoma, rhabdomyosarcoma and osteosarcoma. We report the framework that was used to evaluate agents and the results of this evaluation. Immune checkpoint inhibitors and tyrosine kinase inhibitors were identified by the COG STS Committee as candidate classes of agents for inclusion in phase 2 or phase 3 clinical trials of pediatric NRSTS. Gaps in the existing literature and practical barriers were identified for additional classes of agents to guide future drug development efforts
Climate Impacts and Response Options in the Gulf of Maine
No full textCME available for 1 year after presentation
CME Text Code: 97009
In order to claim CME credit, please complete an evaluation in CloudCME for each presentation.https://knowledgeconnection.mainehealth.org/pediatrics_gr/1066/thumbnail.jp
Summary of: Improving VTE Risk Assessment: Education and Prophylaxis in Rural Cancer Clinics
Get PDF•Cancer-associated thrombosis (CAT) is the second leading cause of death in patients with cancer and is preventable •Venous thromboembolism (VTE) risk assessment and preventative treatment in high-risk patients who are at low risk of bleeding are recommended for outpatients with cancer initiating therapyhttps://knowledgeconnection.mainehealth.org/nnectr/1006/thumbnail.jp
Real-world data of immune-related adverse events in lung cancer patients receiving immune-checkpoint inhibitors
No full textBACKGROUND: Immune-checkpoint inhibitors (ICIs) have revolutionized lung cancer (LC) treatment; however, immune-related adverse effects (irAEs) may occur. The risk factors of irAEs and the impact of irAEs on patient outcomes in LC remain uncertain. MATERIALS AND METHODS: irAEs within 12 months of ICI initiation in LC patients who initiated ICIs 2018-2021 were identified. Cause-specific Cox regression was used to assess risk factors for irAEs with the competing risk of death; a subset analysis was done among non-small cell lung cancer (NSCLC) group. Multivariable Cox regressions were used to evaluate the impact of irAEs on progression-free survival (PFS) and overall survival (OS). RESULTS: Of 125 patients, 50 irAEs occurred in 39 patients. Small cell lung cancer (SCLC) histology was associated with a higher risk of irAEs (Hazard ratio (HR) = 2.73, 95% CI [1.17, 6.35], p = 0.020) than NSCLC. In NSCLC subset, programmed death-ligand 1 (PDL1) positivity (HR = 2.68, 95% CI [1.10. 6.53], p = 0.030) was identified as a risk factor. irAEs were not significantly associated with PFS (HR = 0.69, p = 0.204) or OS (HR = 0.72, p = 0.353). CONCLUSION: SCLC histology and PDL1 positivity were associated with irAEs, and the occurrence of irAEs showed no impact on survival in LC patients. Future studies are required to validate the findings
Mental Health Conditions Among Patients with a Disorder of the Gut-Brain Interaction
Get PDFTwo thirds of pediatric patients with disorders of the gut-brain interaction have mental health comorbidity.https://knowledgeconnection.mainehealth.org/lambrew-retreat-2025/1007/thumbnail.jp
Experiences with Mental Health Screening in Primary Care
Get PDFPatients with psychosis may answer mental health questions less honestly in primary care settings due to experiences with and fear of disclosure of mental health symptoms to legal guardians, involuntary hospitalization, stigma, and dismissal of physical health symptoms.https://knowledgeconnection.mainehealth.org/lambrew-retreat-2025/1024/thumbnail.jp
