Copenhagen University Hospital
CURIS (Copenhagen University Research Information System)Not a member yet
395145 research outputs found
Sort by
Contact Allergy in Children in Europe:A Proposal for a Paediatric European Baseline Series
No full textBackground Contact allergy is common in children, but no paediatric baseline series (pEBS) exists in Europe, despite recommendations in several countries.Objectives To collect and compare patch testing data from European centres to propose a common pEBS, possibly adapted by age group.Materials and Methods Data from 13 centres in 12 European countries were aggregated, covering 1816 children (1099 girls, 60.5%), aged 0-16 years, tested with the adult EBS (aEBS) and other frequent allergens between 2018 and 2022. Allergen selection followed adult criteria, with a stricter cut-off for inclusion, requiring at least 1% positive reactions (lower 95% CI) in children.Results A total of 17 allergens from the aEBS caused positive reactions in >= 1% of children (lower 95% CI). Common allergens included metals, fragrances, and preservatives. Tixocortol-21-pivalate was included despite its lower frequency due to its difficult-to-suspect nature. Additional frequent allergens were hydroperoxides of limonene and linalool, Amerchol L-101, and sorbitan sesquioleate. In total, 18 allergens were identified as potentially qualifying for a pEBS, with a further 7 as recommended additions.Conclusion Results from patch testing children across europe highlight a common set of frequent allergens, which should be considered for a pEBS
Impact of psychiatric disease and treatment on biologic drug survival in patients with hidradenitis suppurativa
No full textEffect of implantable cardioverter-defibrillator in non-ischemic heart failure according to heart failure etiology:Extended follow-up of the DANISH trial
No full textBACKGROUND: Due to differences in clinical profiles and outcomes among patients with different causes of non-ischemic heart failure (HF), the risk of sudden cardiovascular death and the effect of implantable cardioverter-defibrillators (ICDs) may vary depending on HF etiology. We examined the effects of primary-prevention ICDs according to HF etiology in an extended follow-up study of DANISH (Danish Study to Assess the Efficacy of ICDs in Patients With Non-ischemic Systolic Heart Failure on Mortality).METHODS: DANISH randomized 1116 patients with non-ischemic HF to ICD implantation (N = 556) or usual care (N = 550). In this study, outcomes were analyzed by HF etiology.RESULTS: In total, 849 patients (76 %) had idiopathic HF, and 267 (24 %) had non-idiopathic HF (valvular, n = 41; hypertensive, n = 117; other, n = 109). During a median follow-up of 9.5 years, non-idiopathic HF was not associated with a significantly different rate of death from any cause (HR 1.03 [95 %CI,0.82-1.29]) or sudden cardiovascular death (HR 0.92 [95 %CI,0.55-1.55]) compared with idiopathic HF. Compared with usual care, ICD implantation did not reduce the rate of death from any cause in idiopathic (HR 0.89 [95 %CI,0.72-1.11]) or non-idiopathic HF (HR 0.86 [95 %CI,0.59-1.25]), with no interaction between HF etiology and treatment effect (Pinteraction = 0.84). The beneficial effect of ICD implantation on sudden cardiovascular death was not modified by HF etiology (idiopathic: HR 0.60 [95 %CI,0.37-0.97]; non-idiopathic: HR 0.59 [95 %CI,0.24-1.48]; Pinteraction = 0.99).CONCLUSIONS: Rates of sudden cardiovascular death (or all-cause death) did not differ across different etiologies of non-ischemic HF. HF etiology did not modify the effects of primary-prevention ICD implantation compared with usual care.</p
Childhood maltreatment and impaired emotion regulation and processing in remitted affective disorders:Evidence from a large-scale investigation
No full textBACKGROUND: Childhood maltreatment (CM) has been linked to difficulties in emotion regulation and processing in affective disorders, but associations are mixed, underscoring the need for large-scale investigation.METHODS: This cross-sectional study examined associations between CM (overall and subtypes) and emotion regulation and processing in n = 348 individuals with affective disorders (bipolar disorder (BD) = 81 %; major depressive disorder (MDD) = 19 %) in full or partial remission (68 % female, meanage = 33 ± 9 years) and n = 218 healthy controls (HC) (64 % female, meanage = 32 ± 11 years). Baseline data were pooled for the Childhood Trauma Questionnaire, Social Scenarios Task, and Facial Expression Recognition Test. Analyses included Spearman's rho correlations (rs), multiple linear regression, and analysis of covariance.RESULTS: In affective disorders, more overall CM correlated with less successful down-regulation of emotions in negative social scenarios (rs = -0.12, p = .03), surviving adjustment for demographic and clinical factors (B = -0.33, 95 % CI [-0.59,-0.08], p = .010; Benjamini-Hochberg adj. p < .05), with preliminary indications suggesting potential contributions from CM-related sexual abuse and physical neglect. Patients with high vs. low CM displayed less successful down-regulation of negative emotions, lower reactivity in aversive scenarios, and poorer discrimination accuracy of positive facial expressions (ps ≤ .04). Across patients and HC, more overall CM correlated weakly with poorer emotion down-regulation, lower positive emotions reactivity, and slower facial expression recognition (ps ≤ .019).CONCLUSIONS: CM is associated with altered emotion regulation and processing, and specific maltreatment-subtypes may potentially be differentially related to these difficulties across remitted BD and MDD. Assessing CM may inform interventions targeting emotion regulation and processing in affective disorders.</p
Weight gain trajectories from birth to 12 months and cardiovascular risk factors in middle adulthood
No full textBackground and aim: Infant weight gain is positively associated with fat and lean mass later in life, but whether it relates to adult cardiovascular disease (CVD) risk factors is ambiguous. We examined associations between infant weight gain trajectories and adult CVD risk factors. Methods and results: We included 739 individuals from the Copenhagen Perinatal Cohort. Repeated infant weight measurements and information on adult CVD risk factors at age 48–51 years were available. Five infant weight gain trajectories were estimated using latent class modelling (very low-moderately increasing; low-markedly increasing; low-stable increasing; average-stable increasing [reference group]; high-moderately increasing). Linear regression models were adjusted for parental and infant factors and additionally for birthweight. Compared with the average-stable increasing weight gain trajectory, in men, the very low-moderately increasing trajectory was associated with higher systolic and diastolic blood pressure (DBP), triglycerides, low-density lipoprotein and total cholesterol. In women, the low-markedly increasing trajectory was associated with higher DBP and the low-stable increasing trajectory was associated with lower body mass index and body fat percentage. The high-moderately increasing trajectory was associated with higher waist circumference in men and lower total cholesterol in women. Additional adjustment for birthweight attenuated some, but not all, associations. Conclusion: Infant weight gain trajectories were not consistently associated with CVD risk profiles during adulthood. In men, the very-low moderately increasing weight trajectory had a worse CVD risk profile. Women with the low-stable increasing weight trajectory tended to have a better CVD risk profile.</p
Global Discrepancies in Inflammatory Bowel Disease Care Reflect Health Care Expenditure Per Capita
No full text‘Lumpy’ technological innovation systems and net-zero transitions:The impact of technology characteristics on the carbon capture innovation system in Norway
No full textWhile past research indicates that technology characteristics matter for deployment and policymaking, especially for lumpy technologies, these insights have not yet been integrated with more comprehensive understandings of socio-technical diffusion. This is problematic because some net-zero decarbonization challenges require lumpy technologies (e.g., cement). To address this knowledge gap, we articulate a ‘lumpy’ technological innovation systems (TIS) approach by merging literatures on technology characteristics and TIS, deriving three important technology characteristics dimensions for analyzing lumpy technology diffusion: size, complexity, and level of customization. We then test the usefulness of this framework by analyzing the case of carbon capture (CC) innovation for decarbonization of process industrial plants in Norway. These types of CC units, with their large size, high complexity, and high customization requirements, have been notoriously difficult to deploy despite technological maturity. From our analysis, we demonstrate the usefulness of our framework through an empirical case of lumpy technology characteristics directly impacting TIS structures and functions. Theoretically, our findings demonstrate the usefulness of treating the material dimensions of technology as a TIS structure and draw attention to the seldom used materialization function's importance for diffusion of lumpy technologies. Our findings reveal an iterative process by technology developers to alter the characteristics of CC technology, challenging past notions of technology-inherent characteristics. Moreover, our findings confirm the importance of considering technology characteristics in policymaking for net-zero transitions and we contribute a novel approach for policymakers to assess the characteristics of focal technology and why they matter for diffusion.</p
Association between serum high-sensitivity C-reactive protein levels and migraine:a REFORM study
No full textBackgroundHigh-sensitivity C-reactive protein (hs-CRP) is a well-established biomarker of systemic inflammation and endothelial dysfunction. Its role in capturing inflammatory processes underlying migraine remains unclear. We aimed to determine whether serum hs-CRP levels are associated with migraine.MethodsThis cross-sectional study enrolled adult participants with migraine and sex-matched healthy controls (HCs). Serum hs-CRP concentrations (mg/L) were measured using a validated assay. Participants with migraine were categorized into subgroups based on type (with aura, without aura, chronic, episodic) and headache status at sampling (ictal, interictal). The primary outcome was the percentage difference in serum hs-CRP concentrations between participants with migraine and HCs. Secondary outcomes included comparisons of hs-CRP levels across migraine subgroups and between each subgroup and HCs. Multivariate regression models were used to assess associations between hs-CRP and migraine after adjusting for age, sex, body mass index, and smoking status.ResultsA total of 642 participants with migraine and 154 sex-matched HCs were enrolled. Of these, 630 with migraine (565 [89.7%] females) and 153 HCs (131 [85.6%] females) provided eligible outcome data. Participants with migraine exhibited significantly higher hs-CRP concentrations than HCs, with an average increase of 31.2% (95% CI, 9.4–57.3%; P = 0.003). Subgroup analyses showed higher hs-CRP in migraine with aura (47.0% above HCs; P = 0.002) and chronic migraine (33.5% above HCs; P = 0.009).ConclusionsElevated hs-CRP levels were identified in adults with migraine, implicating low-grade inflammation in migraine pathogenesis.Background: High-sensitivity C-reactive protein (hs-CRP) is a well-established biomarker of systemic inflammation and endothelial dysfunction. Its role in capturing inflammatory processes underlying migraine remains unclear. We aimed to determine whether serum hs-CRP levels are associated with migraine. Methods: This cross-sectional study enrolled adult participants with migraine and sex-matched healthy controls (HCs). Serum hs-CRP concentrations (mg/L) were measured using a validated assay. Participants with migraine were categorized into subgroups based on type (with aura, without aura, chronic, episodic) and headache status at sampling (ictal, interictal). The primary outcome was the percentage difference in serum hs-CRP concentrations between participants with migraine and HCs. Secondary outcomes included comparisons of hs-CRP levels across migraine subgroups and between each subgroup and HCs. Multivariate regression models were used to assess associations between hs-CRP and migraine after adjusting for age, sex, body mass index, and smoking status. Results: A total of 642 participants with migraine and 154 sex-matched HCs were enrolled. Of these, 630 with migraine (565 [89.7%] females) and 153 HCs (131 [85.6%] females) provided eligible outcome data. Participants with migraine exhibited significantly higher hs-CRP concentrations than HCs, with an average increase of 31.2% (95% CI, 9.4–57.3%; P = 0.003). Subgroup analyses showed higher hs-CRP in migraine with aura (47.0% above HCs; P = 0.002) and chronic migraine (33.5% above HCs; P = 0.009). Conclusions: Elevated hs-CRP levels were identified in adults with migraine, implicating low-grade inflammation in migraine pathogenesis.</p