Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases

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    819 research outputs found

    Solving Two-Stage Stochastic Steiner Tree Problems by Two-Stage Branch-and-Cut

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    We consider the Steiner tree problem under a two-stage stochastic model with recourse and finitely many scenarios. In this problem, edges are purchased in the first stage when only probabilistic information on the set of terminals and the future edge costs is known. In the second stage, one of the given scenarios is realized and additional edges are purchased in order to interconnect the set of (now known) terminals. The goal is to decide on the set of edges to be purchased in the first stage while minimizing the overall expected cost of the solution. We provide a new semi-directed cut-set based integer programming formulation, which is stronger than the previously known undirected model. We suggest a two-stage branch-and-cut (B&C) approach in which L-shaped and integer-L-shaped cuts are generated. In our computational study we compare the performance of two variants of our algorithm with that of a B&C algorithm for the extensive form of the deterministic equivalent (EF). We show that, as the number of scenarios increases, the new approach significantly outperforms the (EF) approach

    A Fast Exact Algorithm for the Problem of Optimum Cooperation and Structure of Its Solutions

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    Given a graph with real edge weights, the optimum cooperation problem consists in determining a partition of the graph that maximizes the sum of weights of the edges with nodes in the same class plus the number of the classes of the partition. The problem is also known in the literature as the optimum attack problem in networks. Furthermore, a relevant physics application exists. In this work, we present a fast exact algorithm for the optimum cooperation problem. Algorithms known in the literature require n-1 minimum cut computations in a corresponding network, where n is the number of nodes in the graph. By theoretical considerations and appropriately designed heuristics, we considerably reduce the numbers of minimum cut computations that are necessary in practice. We show the effectiveness of our method by presenting results on instances coming from the physics application. Furthermore, we analyze the structure of the optimal solutions

    The Transitive Minimum Manhattan Subnetwork Problem in 3 Dimensions

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    We consider the Minimum Manhattan Subnetwork (MMSN) Problem which generalizes the already known Minimum Manhattan Network (MMN) Problem: Given a set P of n points in the plane, find shortest rectilinear paths between all pairs of points. These paths form a network, the total length of which has to be minimized. From a graph theoretical point of view, a MMN is a 1-spanner with respect to the L_1 metric. In contrast to the MMN problem, a solution to the MMSN problem does not demand L_1 -shortest paths for all point pairs, but only for a given set R subseteq P imes P of pairs. The complexity status of the MMN problem is still unsolved in geq 2 dimensions, whereas the MMSN was shown to be NP -complete considering general relations R in the plane. We restrict the MMSN problem to transitive relations R_T ({em Transitive} Minimum Manhattan Subnetwork (TMMSN) Problem) and show that the TMMSN problem is Max-SNP -complete with epsilon<frac{1}{8} in 3 dimensions

    An Effective Branch-and-Bound Algorithm for Convex Quadratic Integer Programming

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    We present a branch-and-bound algorithm for minimizing a convex quadratic objective function over integer variables subject to convex constraints. In a given node of the enumeration tree, corresponding to the fixing of a subset of the variables, a lower bound is given by the continuous minimum of the restricted objective function. We improve this bound by considering certain lattice-free ellipsoids. Experiments show that our approach is very fast on both unconstrained problems and problems with box constraints. The main reason is that all expensive calculations can be done in a preprocessing phase, while a single node in the enumeration tree can be processed in linear time in the problem dimension

    Preprocessing Maximum Flow Algorithms

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    Maximum-flow problems occur in a wide range of applications. Although already well-studied, they are still an area of active research. The fastest available implementations for determining maximum flows in graphs are either based on augmenting-path or on push-relabel algorithms. In this work, we present two ingredients that, appropriately used, can considerably speed up these methods. On the one hand, we present flow-conserving conditions under which subgraphs can be contracted to a single node. These rules are in the same spirit as presented by Padberg and Rinaldi (Math. Programming (47), 1990) for the minimum cut problem in graphs. On the other hand, we propose a two-step max-flow algorithm for solving the problem on instances coming from physics and computer vision. In the two-step algorithm flow is first sent along augmenting paths of restricted lengths only. Starting from this flow, the problem is then solved to optimality using some known max-flow methods. By extensive experiments on random instances and on instances coming from applications in theoretical physics and in computer vision, we show that a suitable combination of the proposed techniques speeds up traditionally used methods

    Integer Programming Subject to Monomial Constraints

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    We investigate integer programs containing monomial constraints. Due to the number-theoretic nature of these constraints, standard methods based on linear algebra cannot be applied directly. Instead, we present a reformulation resulting in integer programs with linear constraints and polynomial objective functions, using prime decompositions of the right hand sides. Moreover, we show that minimizing a linear objective function with nonnegative coefficients over bivariate constraints is possible in polynomial time

    On efficient total domination

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    An efficiently total dominating set of a graph G is a subset of its vertices such that each vertex of G is adjacent to exactly one vertex of the subset. If there is such a subset, then G is an efficiently total dominatable graph (G is etd). We show that the corresponding etd decision problem is NP-complete on (1,2)-colorable chordal graphs and on planar bipartite graphs of maximum degree 3 and obtain polynomial solvability on T_3-free chordal graphs, implying polynomial solvability on interval graphs and circular arc graphs

    A Graph Class related to the Structural Domination Problem

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    In the structural domination problem one is concerned with the question if a given graph has a connected dominating set whose induced subgraph has certain structural properties. For most of the common graph properties, the associated decision problem is NP-hard. Recently, Bacsô and Tuza gave a full characterization of the graphs whose every induced subgraph has a connected dominating set satisfying an arbitrary prescribed hereditary property. Using the Theorem of Bacsô and Tuza, we derive a finite forbidden subgraph characterization of the distance-hereditary graphs that have a dominating induced tree. Furthermore, we show that for distance-hereditary graphs minimum dominating induced trees can be found efficiently. The main part of the paper studies a new class of graphs, the extit{structural domination class}, which is closely related to the structural domination problem. Among other results, we give new characterizations of certain subclasses of distance-hereditary graphs (in particular for ptolemaic graphs) and analyse the structure of minimum connected dominating sets of structural domination graphs. It turns out that many of the problems associated to structural domination become tractable on the hereditary part of the structural domination class

    Semi-preemptive routing on a linear and circular track

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    The problem of routing a robot (or vehicle) between n stations in the plane in order to transport objects is well studied, even if the stations are specially arranged, e.g. on a linear track or circle. The robot may use either all or none of the stations for reloading. We will generalize these concepts of preemptiveness/nonpreemptiveness and emancipate the robot by letting it choose k le n reload-stations. We will show that the problem on the linear and circular track remains polynomial solvable

    Terse Integer Linear Programs for Boolean Optimization

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    We present a new polyhedral approach to nonlinear boolean optimization problems. Compared to other methods, our approach produces much smaller integer programming models, making it more efficient from a practical point of view. We mainly obtain this by two different ideas: first, we do not require the objective function to be in any normal form. The transformation into a normal form usually leads to the introduction of many additional variables or constraints. Second, we reduce the problem to the degree-two case in a very efficient way, using a slightly extended formulation. The resulting model turns out to be closely related to the maximum cut problem; we show that the corresponding polytope is a face of a suitable cut polytope in most cases. In particular, our separation problem reduces to the one for the maximum cut problem. In practice, our approach turns out to be very competitive. First experimental results, which have been obtained for some particularly hard instances of the Max-SAT Evaluation 2007, show that our very general implementation can outperform even special-purpose SAT solvers

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