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Serum CETP status is independently associated with reduction rates in LDL-C in pitavastatin-treated diabetic patients and possible involvement of LXR in its association
No full textBackground: Statins decrease cholesteryl ester transfer protein (CETP) levels, which have been positively associated with hepatic lipid content as well as serum low density lipoproteins-cholesterol (LDL-C) levels. However, the relationship between the CETP status and statin-induced reductions in LDL-C levels has not yet been elucidated in detail. We herein examined the influence of the CETP status on the lipid-reducing effects of pitavastatin in hypercholesterolemic patients with type 2 diabetes mellitus as well as the molecular mechanism underlying pitavastatin-induced modifications in CETP levels.
Methods: Fifty-three patients were treated with 2 mg of pitavastatin for 3 months. Serum levels of LDL-C, small dense (sd) LDL-C, and CETP were measured before and after the pitavastatin treatment. The effects of pitavastatin,
T0901317, a specific agonist for liver X receptor (LXR) that reflects hepatic cholesterol contents, and LXR silencing on CETP mRNA expression in HepG2 cells were also examined by a real-time PCR assay.
Results: The pitavastatin treatment decreased LDL-C, sdLDL-C, and CETP levels by 39, 42, and 23 %, respectively. Despite the absence of a significant association between CETP and LDL-C levels at baseline, baseline CETP levels
and its percentage change were an independent positive determinant for the changes observed in LDL-C and sdLDL-C levels. The LXR activation with T0901317 (0.5 μM), an in vitro condition analogous to hepatic cholesterol accumulation, increased CETP mRNA levels in HepG2 cells by approximately 220 %, while LXR silencing markedly diminished the increased expression of CETP. Pitavastatin (5 μM) decreased basal CETP mRNA levels by 21 %, and this was completely reversed by T0901317.
Conclusion: Baseline CETP levels may predict the lipid-reducing effects of pitavastatin. Pitavastatin-induced CETP reductions may be partially attributed to decreased LXR activity, predictable by the ensuing decline in hepatic cholesterol synthesis.
Trial registration: UMIN Clinical Trials Registry ID UMIN00001902
図書館forum No.13
No full text内容：
批判的に考える………………………………… 寺尾 健夫 1
文献検索と収集を早くするために
～ PubMed と Discovery の併用～ …………… 佐野 和生 3
■福井大学附属図書館所蔵「小島家文書」を読む（3）
富者の庇護下で生きる人びと
―元禄 12（1699）年、野中組 18 ヶ村の請文から― 長谷川裕子 5
■福井大学附属図書館所蔵の古典籍（10）
江戸の気象学、明逸『通機図解』
―雲の形を見て、気象を予測する― …………… 膽吹 覚 8
「のらくろ」を見て思ったこと
～徒然なるままに～ …………………………… 太田 仁 11
■私の推薦書
数学の学び方を学ぼう …………………… 田嶋 直樹 13
『法学』の扉を開いてみよう ……………… 生駒 俊英 14
化学式が苦手という人にお勧め！
これであなたの分子観も変わる！ ………… 藤井 豊 16
主な行事等 …………………………………………………… 17
平成 27 年度教員寄贈図書 ………………………………… 18
総合図書館企画展示 2015 ………………………………… 19
医学図書館日記 ………………………………………………
Cutting Properties of Tool with Nano-structured Surface against Titanium Alloy
No full textLow thermal conductivity and high chemical reactivity of titanium alloys cause the tool life to shorten. One of the solutions of this problem is cutting by a coated tool has high thermal resistance and low reactivity against cutting materials. In this study, I improve a coated tool to extend the tool life by producing nano-structure on its face by femto-second laser irradiations and investigate cutting properties of the improved tools such as tool wear and cutting temperature in titanium alloys milling.
The cutting temperature is measured using two-color pyrometer with optical fi ber. As a result, the nano-structure decrease the tool wear, but increase the cutting temperature
Vowel generation method focused on outline of frequency spectrum
No full textWe propose a vowel generation method focused on outline of frequency spectrum for a vowel.
One of some vowels is sampled, and modifying it according to the feature of frequency spectrum for
each vowel. In this way, the feature of tone is kept and other four vowels are generated from one
vowel. We have experimented the case of other four vowels were generated from each of vowels /a/, /i/, /u/,/e/, /o/, and evaluated for fi ve vowels obtained by the above method by four test subjects. We obtained good results in the experiment that vowels of /a/, /i/, /u/, and /o/ are generated by modifi ed vowel /e/
Purification of the dyeing waste water by the microbubble
No full textThe regulation about the colored waste water has been already carried out by some Japanese local governments. This regulation for colored waste water may spread out in the whole country, and
the improvement of the purifi cation technology of the coloration waste water is required in future.
The purification technology by the microbubble was applied in most. In this study, the synergetic
effect between a microbubble and an oxidizer were investigated about working to purify dye solution.
As a result, purifi cation of the dye solution needed both an oxidizer and a microbubble. After the main structure of the dye material was destroyed at the beginning because the decrease in absorbency of the coloration solution was considerably faster than a decrease in carbon density, it is considered that the divided organic substance was discomposed. Furthermore, approximately 30% of organic substance were not able to disintegrate even if more oxidizers were added
退院から在宅療養初期においてがん患者および家族が直面する問題
No full text本研究では，がんに罹患した患者が，医療機関から退院し在宅療養に移行するにあたって，また，在宅療養を開始した後にどのような不安や心配を感じているのかを明らかにすることを目的に取り組んだ．
研究は，帰納的アプローチによる質的記述的方法を用いた．研究対象者の選定は当該病院の医師および看護師から事前に対象者に説明を行ってもらい同意が得られた人9名である．研究期間は平成26年12月から平成27年5月までの5か月間である．データ収集の方法は半構成的質問を用いた面接により行われた．
本研究結果からは，退院後においてもがんを予期する過程を経ず，想定していなかった患者は，がんという病気を受容しきれずにいた．また，がんの種類によっては，乳がんでは上肢の可動域障害等により患側上肢の挙上困難感や胃の切除後の患者では，食生活の再構築等の課題を抱えていた．さらに，これから始まるであろう化学療法である抗がん剤の使用については，副作用への恐怖が多く抽出された．また，高齢のがん患者を抱える家族の場合は家族への影響等がデータ分析の結果導かれた．
これからは在宅医療の中心になって患者を日常生活面から支えるのは看護師である．本研究により得られた結果はがん患者に限定したものであると同時に，極少数の患者からのインタビューによるものである．今後は，在宅における看護のあり方や看護技術の開発に繋げるための基礎研究として，さらに発展させていきたいと考える
About a Historical View on the Architect V. Scamozzi’s Architectural Theory in the 16th Century Italy
No full textThis paper aims to make clear the historical evaluation about the architectural theory of the architect Vincenzo Scamozzi in the 16th century Italy. In the 16th century, Italy pushed forward the universalization of the concepts that integrate each art. Yet, Scamozzi constituted a logic that puts Architecture in a high position and puts Painting/Sculpture in its subordinate position. In this logic, the concept that has an important role is “scienza”. Architecture becomes a more excellent art than Painting/Sculpture, on the condition that it secures the inevitable relationship with the scienza. Scamozzi’s architectural book “Idea della architettura universale” is the concept that was composed by the scienza. This paper makes the historical value about the architectural book which proves such thing clear
The Change of the Samurai’s Premises with the Salary Reduction of Jyokyo Three Years A Study on the Samurai’s Premises of the Fukui Castle Town, Part 31
No full textThis paper considers of the change of Samurai’s Premises with the salary reduction of Jyokyo three years. A person of dismissal with the salary reduction was 288 people, and the immigrant was 51 people. It was dismissed 191 people intermediate samurai’s less than 300Koku and the low-class samurai’s. The person of large number of dismissal lived in the perimeter of the Fukui Castle Town. In contrast, there are only four people of dismissal in the center of the Fukui Castle Town.
As for the immigrant, of the aide of Tunamasa MATUDAIRA were picked. Kozaemon TAKADA and Sakonuemon NARA who lived in Keya-Cho moved in the unoccupied house of the center of the Fukui Castle Town. The center of the Fukui Castle Town comes back to the samurai’s premises by Syotoku four years