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Foreign policy in transition:the ANC’s search for a foreign policy direction during South Africa’s transition, 1990-1994
No full textAt the beginning of the transition from apartheid to democracy, the African National Congress (ANC) was unprepared for foreign policy discussion, a lack of readiness magnified by the collapse of international Communism and the Cold War ideology. President De Klerk and the National Party controlled foreign policy in the early years of the transition and began the process of reintegration with the international community, The ANC initially struggled to adapt to the new international situation, whereas De Klerk was successful in wooing the international community. In the later stages of transition, the ANC developed a greater sense of direction and substance in foreign relations, although there were differences of opinion among and between the leadership and the rank and file. Already in 1994 there was evidence of tension between idealism and pragmatism. Post-apartheid foreign policy under Mandela was riddled with inconsistencies, which stemmed from the events of South Africa’s transitio
Quantifying the contribution of organisms to the provision of ecosystem services
No full textResearch on ecosystem services has grown rapidly over the last decade. Two conceptual frameworks have been published to guide ecological assessments of organisms that deliver services - the concepts of service-providing units (SPUs) and ecosystem service providers (ESPs). Here, we unite these frameworks and present an SPU-ESP continuum that offers a coherent conceptual approach for synthesizing the latest developments in ecosystem service research, and can direct future studies at all levels of organization. In particular, we show how the service-provider concept can be applied at the population, functional group, and community levels. We strongly emphasize the need to identify and quantify the organisms and their characteristics (e.g., functional traits) that provide services, and to assess service provision relative to the demands of human beneficiaries. We use key examples from the literature to illustrate the new approach and to highlight gaps in knowledge, particularly in relation to the impact of species interactions and ecosystem dynamics on service provision
APEX1 regulation of aldosterone synthase gene transcription is disrupted by a common polymorphism in humans
No full textRATIONALE: The genetic mechanisms underlying hypertension are unclear, but relative aldosterone excess, present in ˜10% of hypertensive patients, is known to be a heritable trait. This phenotype associates with a T/C single nucleotide polymorphism (SNP) at position -344 of the aldosterone synthase gene (CYP11B2). However, deletion of this SNP has no effect on gene transcription. We have identified another T/C SNP at -1651, in tight linkage disequilibrium with the -344 SNP and here investigate its functional effect on CYP11B2 transcription. OBJECTIVE: We assessed the effect on transcriptional activity of the -1651 T/C SNP in vivo and in vitro and propose the mechanism by which transcriptional activity is altered. METHODS AND RESULTS: We demonstrated that the SNP at -1651 exerts significant allele-dependent effects on CYP11B2 transcription. We confirm binding of the transcriptional repressor APEX1 to -1651T, which is associated with reduced transcriptional activity in relation to the less strongly bound -1651C. We show that inhibiting APEX1 by small molecule inhibition or small interfering RNA (SiRNA) leads to increased CYP11B2 transcription. In addition, overexpression of APEX1 is associated with reduced transcriptional activity. Finally, we also show that -1651T associates with lower excretion rates of aldosterone metabolites in human subjects. CONCLUSIONS: We conclude that APEX1 is a novel transcriptional repressor of CYP11B2 and that differential APEX1 binding at -1651 of CYP11B2 results in altered gene expression. This mechanism may contribute to the observed relationship between CYP11B2 genotype and aldosterone phenotype in a subgroup of hypertensive patients
The Big Brother House is watching you
No full textThe transitory celebrities who compete in Big Brother occupy the arena of their competition agog and open mouthed, for while Big Brother is, apparently, about the contestants, the real star of the reality show is the House in which it takes place. The Big Brother House is a place of mirrors concealing hidden eyes, disembodied voices and multiple voyeurs. Rather than granted refuge in this house, its occupants are exposed in a crazy cottage where Orwell meets vaudeville; and prison cells or luxuriant dens appear overnight installed by mischievous pixies. The BB House is the antithesis of Bachelard’s vertically ordered Oneiric Axis of nightmarish cellar, formal, domestic ‘middle kingdom’, and the dream space of the attic. The Big Brother house is horizontally layered but fabricated, (to build and to lie). The Big Brother House is a model in extremis of what contemporary domestic interior has become. Like a Foucaulvian heterotopia it is an hermetic, apparently complete model of occupancy. Indeed there is no exterior to this house, which is both closed-off and opened-up through live digital streaming, RSS feeds, and text updates. As such the BB House reveals surrealist tendencies: the mirrors are evocative of Magritte; the windows are for the voyeur not external vista; the BB occupants and the TV viewers are passive idle loafers. In this respect, the Big Brother House reflects the spectacular model homes that have adorned expos from the Great to the Ideal Home exhibitions, from Peter and Alison Smithson’s House of the Future (1956) to Archigram’s 1990 Automated House (1967). Like these other models, the BB House is not a ‘real’ home, but is as abstracted as a white card maquette. But the Big Brother House possesses something that these other simulations lack: occupants who are at the same time real and imagined: The Big Brother House is not a fantasy, but an experiment, as empirically valid as any the most Orwellian of rational modernists could desire. Because the design of the house (and the show itself) is iterative and repeated, learning with each iteration from the experiences of the last, it is a continuing experiment in the negotiation between occupancy and constructed space of the most radical kind. This paper explores the emergence and the development of the many Big Brother Houses of the last decade, and the ways in which they have been occupied, in order to discuss issues that affect more general perceptions of the contemporary interior
Plagiarism:a case study of quality improvement in a taught postgraduate programme
No full textPlagiarism is a common issue in education. Software can detect plagiarism but little is known about prevention
E-health::implementation and evaluation research in Scotland - a scoping exercise
No full textWe searched the National Research Register (NRR) to identify funded research in Scotland (or in collaboration with a Scottish partner) in the area of implementation and evaluation of e-health services. A total of 61 research projects were identified which had been funded since 1 January 1995. These projects shared almost 7 pound million of funding (1 pound is $1.9 or (sic)1.3), the main funding sources being the Scottish Government and the European Union. Based on the projects reviewed, the majority of e-health research in Scotland was being conducted within the communication systems domain. Most of the research was being conducted at a single centre: only 14 studies (23%) were multisite. Future collaboration between these researchers, involving larger scale funding bids, may increase the quantity of e-health implementation and evaluation research.</p
Identification of Inhibitors of the Leishmania cdc2-Related Protein Kinase CRK3
No full textNew drugs are urgently needed for the treatment of tropical parasitic diseases such as leishmaniasis and human African trypanosomiasis (HAT). This work involved a high-throughput screen of a focussed kinase set of similar to 3400 compounds to identify potent and parasite-selective inhibitors of an enzymatic Leishmania CRK3-cyclin 6 complex. The aim of this study is to provide chemical validation that Leishmania CRK3-CYC6 is a drug target. Eight hit series were identified, of which four were followed up. The optimisation of these series using classical SAR studies afforded low-nanomolar CRK3 inhibitors with significant selectivity over the closely related human cyclin dependent kinase CDK2.</p
Hiring and firing:a tale of two thresholds
No full textThe negative effect of quits on the willingness of firms to provide on-the-job training is well documented in the theoretical literature. Here we explore the strength of this effect by solving a firm's dynamic optimization problem where there is uncertainty about future productivity and nonzero firing costs. We find that the degree to which quit rates affect hiring depends on the ratio of firing to hiring costs. As this ratio rises, the negative effect of quits becomes less important, eventually reversing itself. We also describe how quit rates affect the firing decision. We highlight some testable implications of our analysis.</p
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