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FXR as a Drug Target to Treat Progressive Familial Intrahepatic Cholestasis
No full textProgressive Familial Intrahepatic Cholestasis (PFIC) is a condition that results in the cirrhosis of the liver and eventually liver failure due to impaired bile flow. If left untreated and even if treated, PFIC will result usually in an early death. While the causes of this disease vary, all types present with a similar symptoms and eventual prognosis. There are four main proposed subtypes of intrahepatic cholestasis: disorders of membrane transport and secretion, disorders of bile acid biosynthesis and conjugation, disorders of embryogenesis and lastly, an unclassified group. The careful maintenance of bile salt homeostasis is crucial to the metabolism of fats and normal liver function. These genes are involved with the regulation and transport of bile from hepatocytes into the gallbladder and eventually to the ileum of the small intestines. Because maintenance of symptoms can be regulated to improve longevity and quality of life, it is important to further elucidate the mechanisms that lead to cholestasis. By understanding these mechanisms we can hope to develop treatments that target specifically the precursors and downstream effectors in the previously indicated genes. With early detection of PFIC, there is an opportunity for therapy, however the current pharmacologic opportunities are few and have a low efficacy. Therefore there is much need for a stronger and more selective treatment that can be directed to the cause of PFIC instead of its symptoms. I postulate that FXR is a good target because of its advantageous position as a transcription factor
2014 -2016 Editorial Board and Note from the Editors
No full textA Note from the Editors
We are delighted to welcome you to Volume 10 of the Vanderbilt Undergraduate Research Journal (VURJ), a selection of some of the finest research conducted within the undergraduate community at Vanderbilt University. In the decade since its inception, VURJ has featured over 100 articles in the sciences, humanities, and social sciences.
After a brief hiatus in 2014, VURJ came back stronger than ever, boasting our most diverse and selective issue yet. With 73 submissions from students at all four of Vanderbilt’s undergraduate schools, 19 outstanding articles were selected for publication. All submitted manuscripts underwent a rigorous multi-step review process, including two to three rounds of readings by trained peer reviewers, and final selection for publication by VURJ’s team of associate editors. In this issue, you will learn about and explore a diverse selection of topics from arts in trauma therapy to the resurrection of extinct species, an exciting assortment that provides a small glimpse into Vanderbilt’s thriving and dynamic academic community.
We encourage you to engage further with this community by contributing some of your own work to our next issue, or by applying to join our team of editors.
Happy reading and best wishes,
Jelena Belenzada
Editor in Chief, 2014-2015
Eriny Hanna
Editor at Large, 2014-201
Andrew B. McGowan, Ancient Christian Worship: Early Church Practices in Social, Historical, and Theological Perspective
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Preface to Cultural Modernism II: Latin America, April 3-4, 2014
No full textThe two articles presented here are part of a larger project hosted by the W.T. Bandy Center for Baudelaire and Modern French Studies at Vanderbilt University, Nashville, TN. They treat the influence of the work of Baudelaire in South America
A Futurist Art of the Past: Anton Giulio Bragaglia’s Photodynamism
Get PDFThe article examines "Un gesto del capo" (A gesture of the head), a 1911 “Photodynamic” picture by Anton Giulio Bragaglia (1890-1960), and discusses its Bergsonian motifs