Diabesity (E-Journal)
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Errata: Hyperinsulinemia: A unifying theory of chronic disease?
Get PDFErrata: The original article was published with an error of hyperinsulinemia improves fibrinolysis, instead hyperinsulinemia impairs fibrinolysis. The error has been corrected in this version
Why a new journal, Diabesity- editorial perspectives
Get PDFI am very pleased to write an inaugural editorial for the new journal, Diabesity as the editor-in-charge. Diabesity is a unique peer-reviewed open access interdisciplinary journal dedicated to publishing high-quality articles in the areas of physiology, pathology and therapeutic aspects of diabetes, obesity and their complications. Diabesity focuses on clinical and experimental pharmacology and therapeutics in any aspect of these metabolic ailments in various experimental and clinical settings. Current therapeutic agents for obesity and diabetes are inadequate as the number of cases is on the rise. Along with public health strategies, development of alternative therapeutic agents is anticipated. Therefore, extensive research is being conducted in this field and is drawing intense attention from researchers, practitioners and the general public. Here arises the significance of a journal like Diabesity which can serve as a platform for knowledge sharing and the promotion and dissemination of new scientific advancements to a wide spectrum of readers
Matrix metalloproteinases in diabesity
Get PDFDiabesity, the Obesity-Diabetes Epidemic, is one of the major global health problems. Complications associated with it resulted in serious complications and need urgent attention for new therapeutic approaches. In recent years, evidence supporting role of Matrix metalloproteinases and their inhibitors in development of diabesity associated complications are increased. Due to their role in diabesity associated complications they may be potential therapeutic targets
Complications of diabetes: an unsolicited epigenetic memory
Get PDFDiabetes is a multifactorial disease, characterized by hyperglycemia and insulin resistance. Diabetic microvascular end points such as retinopathy, cardiomyopathy and nephropathy; and macrovascular complications such as myocardial infarction and strokes, causing premature death in diabetic populations. Despite strong familial clustering is associated with diabetes, the essential role of epigenetic component in the development of diabetes and its complications is inevitable. Several clinical trials and experimental animal studies show the persistence of diabetic vascular complications even after the normalization of glucose in diabetic patients, indicating the role of epigenetic or metabolic memory. Although previous researches on diabetes implicated the role of reactive oxygen species in the pathogenesis and development of diabetic complications, lifestyle factors including diet and exercise and environmental factors are strongly associated in inducing epigenetic changes related to diabetic risk