Acta Medica Indonesiana – The Indonesian Journal of Internal Medicine
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Transcatheter Coil Embolization in Coronary Artery Fistulae
Full text linkCoronary artery fistulae (CAF) is a rare anomaly, mostly with the incidence of congenital CAF 0.1% - 0.2% and the incidence of acquired CAF 0.2% at coronary angiography. Symptomatic or high flow shunting CAF must be treated with surgery or non surgery approach such as transcatheter coil embolization (TCCE). A women 63 years old with chief complain of chest pain since one month ago. The patient had undergone coronary angiography with conclusions as follows 95% narrowing of proximal LAD (left anterior descendens) artery and CAF from LAD into the right atrium. Whereas narrowing of proximal LAD was performed PCI (percutaneous coronary intervention) with the implantation of drug eluting stents, but patients still complained chest pain. CAF decided to do the TCCE. Post TCCE chest pain and ECG evaluation were within normal limits. Key words: coronary artery fistulae, symptomatic, transcatheter coil embolization
The Role of Anti-dengue Virus NS-1 and Anti-protein Disulfide Isomerase Antibodies on Platelet Aggregation in Secondary Dengue Infection
Full text linkAim: to observe the correlation between anti-NS-1 and anti PDI antibodies against platelets function disorder on secondary dengue infection. Methods: 50 patients with secondary DV infection according to WHO criteria were observed by a cross sectional study. Patient’s blood was collected on day 3, 5 and 7 after fever onset. Platelets aggregation test was done to prove the possibility of platelets dysfunction. Anti-NS-1 and anti- PDI antibodies were determined by solid phase ELISA. Results: the inhibition of platelets aggregation was increased among day of observation. Means value of inhibition on day 3 is 46.6%, day 5 is 52.5% and day 7 is 56%. There is a significant difference (p<0.05) of inhibition of platelet aggregation value between days of observation. The antibodies against NS-1 DV and PDI were detected in all 50 sera with the positive rate of 90% develop NS-1 antibodies and 72% of PDI antibodies, on day 3 of symptoms. The highest OD of NS-1 antibodies is detected on the day 3 and decreased on day 7. The OD of PDI antibodies was increased on day 3 and still increasing on day 7. There is a significant correlation between anti NS-1 and PDI antibodies (r=0.386-0.490), while the differences of OD between observation days are not significant (p>0.05). Conclusion: the kinetics profile of NS1 and PDI antibodies responses, which were detected by the third day of symptoms. Dengue patients’ sera inhibited platelets aggregation. NS-1 antibodies and PDI antibodies might have a role on the platelets aggregation dysfunction; however, there is no correlation between them. It is possible that other mechanism involve in the inhibition of platelets aggregation.Key words: anti-NS-1 antibodies, anti PDI antibodies, inhibition platelets aggregation, secondary dengue infection