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Foxc2 is required for proper cardiac neural crest cell migration, outflow tract septation, and ventricle expansion
No full textBackground: Proper development of the great vessels of the heart and septation of the cardiac outflow tract requires cardiac neural crest cells. These cells give rise to the parasympathetic cardiac ganglia, the smooth muscle layer of the great vessels, some cardiomyocytes, and the conotruncal cushions and aorticopulmonary septum of the outflow tract. Ablation of cardiac neural crest cells results in defective patterning of each of these structures. Previous studies have shown that targeted deletion of the forkhead transcription factor C2 (Foxc2), results in cardiac phenotypes similar to that derived from cardiac neural crest cell ablation. Results: We report that Foxc2‐/‐ embryos on the 129s6/SvEv inbred genetic background display persistent truncus arteriosus and hypoplastic ventricles before embryonic lethality. Foxc2 loss‐of‐function resulted in perturbed cardiac neural crest cell migration and their reduced contribution to the outflow tract as evidenced by lineage tracing analyses together with perturbed expression of the neural crest cell markers Sox10 and Crabp1. Foxc2 loss‐of‐function also resulted in alterations in PlexinD1, Twist1, PECAM1, and Hand1/2 expression in association with vascular and ventricular defects. Conclusions: Our data indicate Foxc2 is required for proper migration of cardiac neural crest cells, septation of the outflow tract, and development of the ventricles. Developmental Dynamics 247:1286–1296, 2018. © 2018 Wiley Periodicals, In
September 14, 2018 Meeting Minutes
Get PDFMinutes of the September 14, 2018 Board of Trustees meeting
Hoople Fruit Farm (1 of 2)
No full textMariah Marsden talks with Mary Hoople Freeman about her family stories prior to the start of their interview at the farm.https://digitalcommons.shawnee.edu/hfforalhistories/1001/thumbnail.jp
Gathering
Get PDF33 X 88 banner titled Gathering. The banner is one of nine banners that are a part of the Placemaking in Scioto County, Ohio traveling exhibit. This banner will be on display at the Southern Ohio Medical Center Life Center & Connex from December, 2018 - August, 2019
Evans, Scott
No full textServed from 2015-2024.https://digitalcommons.shawnee.edu/botmembers/1010/thumbnail.jp
Ferguson, Orville R. Sr.
No full textServed from 1970-1977, 1984-1993.https://digitalcommons.shawnee.edu/botmembers/1011/thumbnail.jp
Kennedy, Phyllis
No full textServed 1975-1984.https://digitalcommons.shawnee.edu/botmembers/1021/thumbnail.jp
Stevens, Robert
No full textServed from 1970-1977.https://digitalcommons.shawnee.edu/botmembers/1039/thumbnail.jp
Roberts, Rita
No full textServed from 2009-2018.https://digitalcommons.shawnee.edu/botmembers/1035/thumbnail.jp
McKinley, William
No full textServed from 1998-2007.https://digitalcommons.shawnee.edu/botmembers/1024/thumbnail.jp