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Investigation of FX-11 Induced Oxidative Stress on Hsp90 Expression in HL60 Acute Myeloid Leukemia Cells
No full textAcute myeloid leukemia (AML) is a promyelocytic cancer characterized by uncontrolled hematopoietic progenitor cell division. AML exhibits an unusual basal metabolic phenotype called the Warburg Effect. The Warburg Effect describes cells who rely on glycolysis and fermentation to produce energy instead of utilizing the conventional mitochondrial aerobic respiration pathways. FX-11 is a lactate dehydrogenase A inhibitor that prevents cells from performing fermentation, thus forcing the cells to rely on their mitochondria to produce energy. This in turn increases reactive oxygen species (ROS). Studies have shown Hsp90, an important molecular chaperone that provides a protective function for cancer cells, is susceptible to cleavage by ROS. This study aims to examine mechanisms of FX-11 toxicity in HL60 AML cells by performing in vitro cytotoxic assays, measuring ROS species production and measuring Hsp90 levels with treatment
AI in Business
No full textAbstract This persuasive essay examines whether Artificial Intelligence (AI) positively affects business, ultimately arguing that it does, particularly when evaluated through the ethical framework of utilitarianism. The essay outlines AI’s rapid advancement, from machine learning and generative models like ChatGPT to autonomous systems, and highlights its transformative impact on efficiency, innovation, decision-making, and workforce development. Although the paper acknowledges significant counterarguments, including job displacement, high implementation costs, privacy risks, algorithmic bias, and loss of human judgment, it contends that these challenges are outweighed by AI’s long-term benefits. Automation reduces operational costs, improves accuracy, enhances customer service, and opens opportunities for new high-skill roles. Moreover, emerging regulations aim to resolve ethical and privacy concerns. Using utilitarian reasoning, the essay concludes that AI maximizes overall societal and organizational good by increasing productivity, promoting economic growth, and enabling better business outcomes, despite temporary setbacks and ethical considerations
February 14, 2025 Meeting Minutes
Full text linkMinutes of the February 14, 2025 Board of Trustees meeting
Navigating Ethical Responsibilities at the A-Plant in Piketon, Ohio: Applying Corporate Social Responsibility and Investment Frameworks
Full text linkAn ethical dilemma in the Appalachian region can be illustrated with the Portsmouth Gaseous Diffusion Plant, referred to as the A-Plant. Initially, it was constructed to produce nuclear military weapons during the Cold War, the plant was then used as a uranium production energy for commercial use throughout the country. In positive terms, the plant helped the economy, created a path to energy independence and was a front line for national security. Contrary, it posed a severe threat to the environment, public safety and health as contamination, radiation exposure and the lack of transparency from officials put communities at risk.
This study will argue the A-plant ethical responsibility using theoretical frameworks such as Corporate Social Responsibility (CSR) and Corporate Social Investment (CSI). It will weigh the economic benefits of the operation with the environment and public damages made evaluated on the long-term consequences. The plant’s failure in decision-making, taking responsibility for ethical behaviors, risks due to contamination and the impact on the surrounding area will be addressed.
This paper will also compare the A-Plant situation with other cases such as the BP Deepwater Horizon Spill and the Chernobyl Disaster, where both cases show that prioritizing profit and public over ethical duties can be dangerous. This paper concludes that corporations need to have stricter regulation, full transparency and a long-term plan for remediation. To obtain the trust of the stakeholders again, A-Plant and similar corporations need to commit to strict ethical plans, sustainable business practices and responsible management programs
Discussing the Opioid Crisis Through Corporate Action and Blue Collar Workers in Appalachia: A Study Based on Purdue Pharma Case
Full text linkThe opioid epidemic, particularly in the Appalachian region, has revealed significant ethical dilemmas in the pharmaceutical industry, notably the role of companies like Purdue Pharma in exacerbating the crisis. This paper examines the ethical responsibility of pharmaceutical companies within the context of the opioid crisis through the lens of Utilitarianism, which advocates for decisions that maximize the overall well-being of society. The analysis argues that pharmaceutical companies should prioritize public health and societal well-being over profit maximization, as guided by ethical frameworks like Utilitarianism and corporate social responsibility (CSR). Despite the economic argument for maximizing profits, past cases like Purdue Pharma\u27s deceptive marketing of OxyContin illustrate the severe societal impacts of ignoring ethical obligations. The paper contrasts this with Milton Friedman’s shareholder theory, which emphasizes profit over social responsibility. Ultimately, the paper asserts that adopting a Utilitarian approach not only aligns with ethical business practices but also enhances long-term business success by fostering trust, sustainability, and building a good reputation. By prioritizing the greater good, pharmaceutical companies can both contribute to public welfare and achieve lasting financial success.
Keywords: Opioid crisis, Appalachian region, Utilitarianism, corporate social responsibility (CSR), Purdue Pharma, shareholder theory, profit maximizatio
Sacrificing the Few for the Many
Full text linkIn this paper, we examine an ethical dilemma surrounding the environmental and social impacts of uranium enrichment activities at the Portsmouth Gaseous Diffusion Plant in Piketon, Ohio. Framing the issue through the opposing ethical frameworks of Contractualism and Utilitarianism, we explore whether the economic benefits derived from plant operations justify the environmental and health risks imposed on the local community. Utilitarianism emphasizes the overall benefits to society, including job creation and economic development, while Contractualism argues for the protection of vulnerable groups, demanding fairness and transparency. Through three key arguments—environmental contamination, increased cancer rates, and economic losses in agriculture—we conclude that the long-term harms inflicted on local residents outweigh both real and speculative economic gains. Applying John Rawls\u27 veil of ignorance thought experiment, we argue that true justice demands prioritizing the well-being of the most vulnerable and that the economic benefits of plant activities should not be allowed to dominate concerns related to the environmental and social costs
Artificial Intelligence Applications for Citizen Science Cricket Cell Counting
No full textStudies have shown that crickets living in higher levels of noise pollution may have a lower chance of reproducing, causing devastating effects on the cricket population. Recent work involving crickets in the Hawaiian Islands has studied this by collecting sperm samples to compare the ratio of living to dead cells under the hypothesis that crickets in louder environments could be prone to infertility. Currently, the cricket study relies on crowd sourced citizen scientist help to count the number of cells per sample by hand and record their results on their website. Problematically, citizen science volunteers may not be qualified to recognize cells in a sample. This project aims to address this research need through Artificial Intelligence (AI) to automate the process of counting these cells. With the implementation of our AI, we have created a much faster and more reliable method for completing this tedious task. Analysis is conducted to compare human-annotated cricket cell counts with AI-generated annotations, assessing both consistency and the potential for detecting previously uncounted cells. The result of this project is a repeatable and reliable system which does not require possibly untrained crowd sourced solutions that speeds up a key, but tedious task, in biology and helps shorten the path to scientific discovery
WITHDRAWN - From Homes to Hazards: A Vision for Portsmouth Through the Lens of the Broken Windows Theory
No full textPortsmouth, Ohio, once a vibrant city in Southern Ohio, has witnessed significant changes over the years, from a bustling center of commerce and community to a town marked by visible signs of decline. This study examines how the principles of the Broken Windows Theory apply to Portsmouth\u27s transformation, focusing on the decay of its physical environment and the resulting social and economic consequences. By highlighting areas of disrepair, such as vacant properties, abandoned buildings, and neglected public spaces, the study underscores how these visible signs of neglect foster a cycle of apathy, disinvestment, and crime. By addressing these issues and applying the Broken Windows Theory, this work aims to demonstrate how revitalization efforts, such as cleaning up vacant properties, repairing condemned buildings, and improving public spaces, can help reduce crime, foster community engagement, and restore Portsmouth as a place of pride. Ultimately, the study envisions a revitalized Portsmouth, where a renewed sense of purpose and community effort can break the cycle of decay, creating a safer, cleaner, and more vibrant city for future generations
Challenges Faced by the Nurse Educator
No full textThe nurse educator’s role, whether in academia or a health care environment, is critical to shaping the future of nursing practice as they educate, mentor, and promote professionalism in students and staff nurses. The nursing educator is continually challenged to provide current and consistent content with evidence-based practice in an ever-evolving, complex health care environment. When developing a course, it is essential for nurse educators in an academic institution or health care facility to consider the needs of the learners in the course. Nurse educators must incorporate learning theories that best align with learning styles and teaching strategies to promote desired outcomes for students. It is essential to include both formative and summative evaluation methods to accurately measure attainment of overall learning outcomes