International Journal of Global Community (Riksawan Institute - IJGC-RI)
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Een begerenswaardig boek. Recensie van: Pius II, Commentaries. Volume I: Books I-II, bezorgd door Margaret Meserve en Marcello Simonetta
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Neonatal capsaicin causes compensatory adjustments to energy homeostasis in rats
No full textSeveral mechanisms involved in ingestive behavior and neuroendocrine activity rely on vagal afferent neuronal signaling. Seemingly contradictory to this idea are observations that vagal afferent neuronal ablation by neonatal capsaicin (CAP) treatment has relatively small effects on glucose homeostasis and long-term regulation of energy balance. It may be proposed that humoral endocrine factors and/or their sensitivities compensate for the loss of vagal afferent information, particularly when subjects face disturbances in ambient fuel levels. Therefore, male adult rats neonatally treated with CAP or with the vehicle (VEH) underwent intravenous glucose tolerance tests (IVGTTs) during which blood fuel levels, and circulating adipose, pancreatic, and adrenal hormones were assessed. CAP rats displayed similar hyperglycemia as VEH rats, but with markedly reduced plasma insulin and corticosterone responses. These results indicate that CAP rats have increased insulin sensitivity during hyperglycemic episodes, and lower plasma levels of corticosterone in CAP rats relative to VEH rats could underlie this effect. After the IVGTT, CAP rats had increased plasma adiponectin and reduced plasma resistin levels, and these alterations in adipose hormones might be relevant for post-ingestive metabolic processes. In a second experiment, anorexigenic efficacies of cholecystokinin and leptin were assessed. While VEH rats, but not CAP rats, responded with reduced food intake to i.p. injected cholecystokinin, only CAP rats responded to i.v. infused leptin with a reduction in food intake. It is concluded that reduced HPA axis activity and/or increased leptin signaling could underlie compensations in fuel handling and energy balance following CAP treatment. (c) 2006 Elsevier Inc. All rights reserved.</p
Nieuwe bewoners van het terpengebied en hun rol bij de opkomst van Fries koningschap. De betekenis van gouden bracteaten en bracteaatachtige hangers uit Friesland (vijfde-zevende eeuw na Chr.)
No full textRecensie van: F.G. Droste, Over de oorsprong van de taal of hoe wij sprekend mens geworden zijn (Symbolae. Facultatis Litterarum Lovaniensis, Series C, Vol. 9). Universitaire Pers Leuven
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