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233 - Synthesis and Evaluation of 1,10-Phenanthroline Ruthenium-Arene Complexes to Modulate the Aggregation of the Amyloid-β Peptide
Get PDFAlzheimer’s Disease (AD) is a neurological disorder characterized by a buildup of the amyloid beta (Aβ) peptide as aggregate species in the brain. Recent advances using antibody based treatments which target Aβ have seen clinical success, achieving FDA approval. However, they come at a significant cost, ranging from $20,000-40,000 a year. Ruthenium-based therapeutics are promising alternatives, as they have shown an ability to modulate the aggregation of Aβ in solution and prevent its cytotoxicity. Despite their initial success, significant questions regarding the affinity of the complexes for Aβ relative to endogenous proteins remain unknown. Therefore, we have synthesized a series of phenanthroline ruthenium-based complexes and assessed their respective ability to modulate Aβ aggregation while also evaluating their association with the serum protein albumin (HSA). The impact on Aβ aggregation for the complexes was assessed using thioflavin T fluorescence, dynamic light scattering, and transmission electron microscopy. Alternatively, the affinity of the complexes for HSA was determined using fluorescence binding assays. The results of these experiments will be discussed, where structure-activity relationships will be established
086 - Shongo Valley Creek Thin Skinned Slump Monitoring and Modeling
Get PDFThis study describes geomorphology, triggers, and monitoring of a slow, rotational slope failure at Shongo Valley Creek in Caneadea, NY. One- and two-dimensional (dry/wet) factor of safety (FS) models were produced using a 1-meter digital elevation model (DEM) in ArcGIS Pro. Fieldwork and drone imaging were also completed for active slide monitoring and informing FS analysis. The Factor of safety (FS) is a non-dimensional ratio relating resisting and driving forces for failure. FS values above 1.2 indicate slopes that are unconditionally stable, 1 stable, 0.8 unstable, and below 0.8 unconditionally unstable. The analysis revealed most of the region surrounding Shongo exhibited stability (FS 1 to 10), some small zones of instability were identified along the canyon walls of Shongo Creek (FS 0.2 to 1). One of the locations of low FS values corresponds to a steep-walled, east-facing cut-bank comprised of thick (10m), Pleistocene-age, lacustrine clay deposits (varves) overlain by a 1-meter-thick permeable gravel layer. These deposits were identified in areal and field data. We posit that the gravel layer serves as a conduit for surface water flow, applying pore pressure at the interface of the clay-rich deposits. However, the FS models indicate that this relationship alone may not be sufficient to trigger failure. Hillslope failure is ultimately triggered here by undermining Shongo Creek. Field reconnaissance further indicates that FS models runs had limitations by only considering single compositions, precipitation values, and deposit thickness, whereas the area comprises various surface geology type, thicknesses, contributing drainage areas, and specific external triggers
Emphasizing a Student-Centered Process: Open Pedagogy Course Assessments Across Disciplines
Get PDFEmphasizing a Student-Centered Process: Open Pedagogy Course Assessments Across Disciplines showcases how Open Educational Practices (OEP) empower students as active contributors to knowledge creation. Grounded in constructivist principles, this collection highlights student-centered assessments—from collaborative course design and renewable assignments to generative artificial intelligence—that foster critical thinking, active learning, and inclusivity. Through practical examples and reflective discussions, the book provides educators with actionable strategies to integrate open pedagogical practices across disciplines while addressing challenges such as institutional support, professional development, and resource accessibility.https://knightscholar.geneseo.edu/oer-ost/1036/thumbnail.jp
