52426 research outputs found
Sort by
Updates in Lipid Management: The Role of Non-statin Lipid Lowering Therapies and Genetic Testing
No full textGJB2-Related Hearing Loss: Genotype-Phenotype Correlations, Natural History, and Emerging Therapeutic Strategies.
No full textThis review integrates molecular, clinical, and translational data to provide an updated understanding o
Psychosocial Health of Health Professions Students: A Concept Analysis.
No full textBACKGROUND: Enrollment as a student in a health professions program is reported to be stressful and to impact psychosocial health (PH).
PURPOSE: A concept analysis of PH was conducted using Rodgers\u27 method in the context of these programs.
METHODS: Independent, blinded PRISMA review of 3719 works revealed 35 relevant studies. Narrative summary tables were derived based on evidence synthesis. Antecedents, attributes, consequences, a model case, and a conceptual model were identified.
RESULTS: Pre-conditioned by students\u27 developmental, social, and environmental characteristics, attributes of PH were: (1) mental health, stress, coping, locus of control; (2) resilience, emotional intelligence, mindfulness, hope; (3) self-esteem; (4) social support; (5) physical health, self-care; (6) academic work-life balance; and (7) academic pressure, workload, external influences.
CONCLUSIONS: PH has tangible impacts on academic and clinical performance. Efforts by educators and practicing clinicians to enhance students\u27 PH make a difference
Remote Patient Monitoring Impact on Short-Term Outcomes for Individuals With Hypertensive Disorders of Pregnancy
No full text
Medication Barriers in Pediatric Patients With Epilepsy.
No full textBACKGROUND: To identify the most common medication adherence barriers among pediatric patients with epilepsy, standardized screening was implemented in a child neurology division using the Barriers to Adherence Tool.
METHODS: The Barriers to Adherence Tool was implemented as a standardized previsit questionnaire for follow-up encounters for seizures/epilepsy. Responses from July 2021 to March 2025 were analyzed.
RESULTS: The questionnaire was completed for 12,466 of 16,808 (74%) follow-up encounters for 5251 patients. At least one barrier was reported at 4351 (35%) encounters with completed questionnaires. The most common barriers included side effects (1612 barriers endorsed; 25%), does not control seizures (1000; 16%), trouble remembering medication (792; 12%), dislike medication taste (684; 11%), other (592; 9%), run out of medication (363; 6%), and too many medications/doses (320; 5%). Barriers were more often reported among patients who self-reported as Black/African American, experienced frequent seizures, or took more than one antiseizure medication. Conversely, barriers were reported less often among patients who self-reported as White, were seizure free or experienced infrequent seizures, or took one antiseizure medication. Among the 1166 patients who completed the questionnaire multiple times and endorsed a barrier at the first encounter, reported barriers were fewer at the last encounter for 770 patients (66%), unchanged for 277 patients (24%), and increased for 119 patients (10%).
CONCLUSIONS: Screening for medication barriers was feasible for a large cohort of patients in a sustainable and repeatable manner, and barriers were common. Future improvement initiatives may focus on improving common barriers
Illicit Opioid Adulterant Trends in Patients Presenting with Acute Opioid Overdose.
No full textBACKGROUND: Clandestine fentanyl manufacturing oftentimes introduces adulterants and contaminants. This paper aims to evaluate trends in adulterants from a cohort of patients presenting to the emergency department (ED) with illicit opioid overdose across the United States.
METHODS: The Fentalog Study group is a multicenter toxicology study group which evaluated ED patients with suspected opioid overdose at 10 medical centers across the United States between September 21, 2020 through February 5, 2024. Comprehensive qualitative toxicology testing was performed on residual serum specimens. Study sites were divided into three geographic regions: West (California, Oregon, Colorado), Midwest (Missouri, Michigan), and East (New York, New Jersey, Pennsylvania, Georgia). Illicit opioids were defined as fentanyl and fentanyl analogs, heroin or its metabolites, and/or novel potent opioids such as nitazenes.
RESULTS: 1295 patients with confirmed illicit opioid overdose were included. Males accounted for the majority (73.7%) of patients. The median age was 39 (IQR: 31-54) years. Adulterants were detected in 745 (57.5%) patients. Quinine was the most abundantly encountered adulterant (433; 33.4%). Antihistamines were the most frequently detected class of adulterants (19.6%). There were significant differences in adulterants detected across the three time periods, with notable decreases in adulterants from time-period 1 (79.5%) to time-period 3 (41.7%; p \u3c 0.001). Adulterants were found in 84 (27.0%) of patients that presented to a hospital in the Western United States, compared with 181 (24.3%) in the Midwest, and 480 (64.4%) of patients in the East (p \u3c 0.001). Patients with concurrent cocaine were more likely having an adulterant present than those without cocaine present (OR 1.23; 95% CI 1.15-1.31). In contrast, patients with illicit opioids and concurrent methamphetamine were less likely to have adulterants present (OR 0.89; 95% CI 0.84-0.95).
CONCLUSIONS: Adulteration of illicit opioids was more likely in the Eastern United States and for those with concurrent cocaine and opioid exposures