Journal of Science and Application Technology (JSAT - Institut Teknologi Sumatera)
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TERATOGENIC RISKS OF COSMETIC INGREDIENTS DURING PREGNANCY: REVIEW
Cosmetics are one of the necessities, especially for women to maintain healthy skin and appearance to become more confident. Cosmetics are products that are widely applied to the body, especially the skin, and their compositions come into contact with the skin for many years with the user. Therefore, the ingredients used in cosmetics must be safe and have concentrations that can be tolerated by the body, so as not to cause ongoing harmful effects. According to European law, all cosmetics approved for circulation in the European Union must be safe for users, and the responsibility for this lies with manufacturers, distributors, and importers. However, the use of cosmetics can have undesirable effects due to the presence of certain chemicals. often, these chemicals have harmful and long-lasting effects, especially for pregnant women as they can affect foetal growth and development. There are cosmetic ingredients that have been shown to be teratogenic and potentially harmful during and after pregnancy. This review explores the various teratogenic substances, their impact on pregnancy, and how to prevent the use of teratogenic cosmetic ingredients. It is acknowledged that exposure to mercury during pregnancy and childhood poses a serious risk to public health. To effectively guide future cosmetic recommendations, more studies especially examining mercury, hydroquinone, retinoic acid from cosmetics are necessary.
Key words: Cosmetics, Hydroquinone, Mercury, Retinoic acid, Teratogenic.
 
INESIA LOTION INSTABILITY: EFFECTS OF OPACIFIER AND THICKENER CONCENTRATION AND REFORMULATION
This study aims to analyze the effect of opacifier (Titanium Dioxide) and thickener (Carbomer) concentrations on phase instability in Inesia Hand and Body Lotion Midsummer products, and to formulate reformulation solutions to improve their stability. Initial observations on the commercial product (Formula F1) showed severe phase instability, characterized by two-layer separation after 27 hot-cold cycle tests. To address this, three experimental formulas (F3, F4, F5) were designed by varying the concentrations of Carbomer and Titanium Dioxide, using F1 as an unstable control and F2 as a stable control. Accelerated stability test results over 27 cycles showed that Carbomer concentration was the dominant factor in determining emulsion stability. Formulas F1 and F4, with low Carbomer concentrations (0.12% and 0.14%), experienced significant instability (total separation in F1, slight creaming in F4) exacerbated by higher Titanium Dioxide concentrations. In contrast, Formula F5 (1,20% Carbomer, 0.09% TiO2) showed emulsion stability, maintaining perfect homogeneity for 26 cycles. Interestingly, Formula F3 (0.16% Carbomer, 0.10% TiO2) also proved to be very stable and equivalent to F2, indicating an effective threshold for optimal stability. Organoleptic evaluation supported the physical stability findings. Increasing Carbomer concentration proved to be an effective reformulation strategy in overcoming phase instability in Inesia body lotion. This research provides a scientific basis for the development of more stable cosmetic products.
 
Analisis Proteksi Sistem Distribusi Listrik Overcurrent Relay (OCR) Berdasarkan Standar IEC 60255-151 dan IEEE C37
Gangguan arus lebih (overcurrent) dalam sistem distribusi tenaga listrik dapat menyebabkan kerusakan peralatan, hilangnya pasokan energi, hingga risiko kebakaran. Oleh karena itu, diperlukan sistem proteksi yang andal dan sesuai dengan standar internasional. Penelitian ini menganalisis kinerja Overcurrent Relay (OCR) dalam mendeteksi dan merespons gangguan, dengan mengacu pada standar IEC 60255-151 dan IEEE C37.112 serta IEEE C37.113. Simulasi dilakukan menggunakan perangkat lunak ETAP 19 dengan skenario gangguan tiga fasa (3φ) di salah satu bus sistem distribusi. Relay terdekat dengan titik gangguan bekerja lebih cepat, sementara relai lainnya bertindak sebagai cadangan (backup), sesuai prinsip grading waktu. Temuan ini menegaskan pentingnya pemilihan parameter proteksi yang tepat agar OCR dapat berfungsi secara optimal dan terintegrasi dalam sistem distribusi listrik modern
Desain Antarmuka Menggunakan SCADA Pada Sistem Pemadam Kebakaran Otomatis Gedung Perkuliahan Berbasis PLC (SPALIC)
Dalam situasi darurat seperti kebakaran, kecepatan dan ketepatan informasi sangat krusial dalam mendukung pengambilan keputusan. Oleh karena itu, penelitian ini merancang sistem antarmuka berbasis Supervisory Control And Data Acquisition (SCADA) untuk sistem pemadam kebakaran otomatis gedung perkuliahan berbasis Programmable Logic Controller (SPALIC) yang informatif, responsif, dan mudah dipahami pengguna. SCADA didesain menggunakan software WinTr yang terintegrasi pada Programmable Logic Controller (PLC) tipe Fultek CPU One. Sistem ini memungkinkan pemantauan secara real-time terhadap tiga jenis sensor (Sensor Asap, Sensor Suhu, dan Sensor Tekanan Air) yang terintegrasi pada ESP32 yang kemudian diintegrasikan ke PLC. Sistem pemantauan ini juga dapat memvisualisasikan kondisi sistem SPALIC serta mengontrol dari jarak jauh, sehingga operator memiliki kendali penuh terhadap sistem tanpa harus hadir secara fisik di lokasi. Terdapat dua pengujian yang dilakukan, yaitu pengujian akurasi data sensor dan pengujian User Experience (UX). Hasil pengujian akurasi data dilakukan dengan membandingkan nilai deteksi sensor yang tampil pada serial monitor Arduino IDE dan tampilan SCADA yang menunjukan tingkat akurasi mencapai 100%. Hasil pengujian UX dengan metode System Usability Scale (SUS) mendapatkan Skor rata rata 45,5 dengan kategori “Good”. Dari kategori pertanyaan pengetahuan pengguna rata-rata persentase responden yang memberikan penilaian positif berada pada angka 86%. Sementara itu, dari kategori pertanyaan kinerja sistem rata-rata persentase penilaian positif mencapai 92%
Optimasi Portofolio Berdasarkan Model Mean-Variance dengan menggunakan Lagrange Multiplier pada saham IDX30
This study aims to optimize the portofolio of stocks included in the IDX30 index using the Mean-Variance model developed by Markowitz. The Lagrange Multiplier method is used in this study to determine the optimal fund allocation by minimizing risk and optimizing expected return. The data used is the daily closing price of stocks from 15 companies listed in the IDX30 index over the last five years (2019-2024). The results show that the Mean-Variance and Lagrange Multiplier methods are effective in identifying the optimal portofolio that can minimize investment risk while maximizing return
FORMULATION AND STABILITY EVALUATION OF NATURAL SHOWER GEL CONTAINING PIPER BETLE HYDROSOL AND WHITETEN™
The growing interest in natural-based personal care products has encouraged the development of innovative cosmetic formulations, including shower gels. This study aimed to formulate and evaluate the physical stability of a shower gel containing Piper betle L. leaf hydrosol and WhiteTen™, a botanical-derived brightening complex. The product was prepared through a four-phase process using ingredients such as Sodium Laureth Sulfate, Cocamidopropyl Betaine, PEG-40 Hydrogenated Castor Oil, Menthol, and preservatives, with the pH adjusted to 5.5–6.5. The formulation was evaluated for its organoleptic properties, pH, viscosity, spreadability, rinseability, foam height, and stability under accelerated storage conditions using six temperature cycling periods. The results showed that the shower gel demonstrated stable physical characteristics, including suitable viscosity, good foaming capacity (60 - 80 mm), ease of rinsing (10 seconds), and consistent pH values across different storage temperatures. The incorporation of WhiteTen™ contributed to the product’s brightening potential, enhancing its value as a multifunctional cosmetic. No significant changes were observed in physical appearance or performance after stability testing, indicating that the formulation is stable and suitable for further development as a safe, natural, and functional skincare product
THE POTENTIAL OF FRAGRANT PANDAN LEAVES AS ACTIVE INGREDIENTS IN COSMETIC PRODUCTS: PHYTOCHEMICAL ANALYSIS
This study aimed to evaluate the phytochemical composition of Pandanus amaryllifolius (fragrant pandan) leaf extract as a preliminary assessment of its potential application in herbal cosmetic formulations. The extraction was performed using the maceration method with 95% ethanol as the solvent. Qualitative phytochemical screening was conducted to identify major classes of secondary metabolites. The results confirmed the presence of alkaloids, flavonoids, tannins, polyphenols, and saponins, while steroids and triterpenoids were not detected. Each identified compound group is known to contribute important biological activities, including antioxidant, anti-inflammatory, and antimicrobial effects, which are desirable in topical skincare products. These findings provide foundational evidence that P. amaryllifolius leaves are a promising natural source of multifunctional bioactive compounds for future cosmeceutical development
Gambaran kualitas hidup pasien kanker payudara di Rumah Sakit Umum Daerah Dr. H. Abdul Moeloek Lampung
Kanker payudara pertumbuhan abnormal pada sel pada payudara dengan gejala awal berupa benjolan pada payudara. Penyakit ini memiliki mortalitas tertinggi yang terjadi pada tahun 2020 sebesar 84.996 kasus. Kemoterapi adalah salah satu terapi yang dapat dapat mempengaruhi kualitas hidup pasien. Penelitian ini bertujuan untuk mengetahui karakteristik pasien dan gambaran kualitas hidup pasien kanker payudara yang mendapatkan kemoterapi di RSUD Dr. H. Abdul Moeloek dengan menggunakan instrumen kuesioner EORTC QLQ BR-23. Jenis penelitian ini adalah non - eksperimental secara kuantitatif dengan pendekatan cross-sectional dan teknik purposive sampling. Subjek penelitian ini adalah pasien kanker payudara berusia ≥18 tahun yang menjalani kemoterapi di poli bedah onkologi yang memenuhi kriteria inklusi dan eksklusi dengan jumlah sampel penelitian sebanyak 111. Hasil penelitian ini menunjukkan mayoritas pasien kanker payudara berusia >40 tahun (91%), berjenis kelamin perempuan (100%), tingkat pendidikan rendah (59,5%), tidak bekerja (66,7%), mengidap kanker stadium lanjut (54,1%), serta gambaran kualitas hidup pasien kanker payudara dengan kemoterapi adalah kualitas hidup rendah (10,8%), sedang (70,3%) dan tinggi (18,9%)
Pemodelan dan Simulasi Sistem Proteksi Jaringan Distribusi Industri Berdasarkan Standar IEC 60255-151 dan IEEE C37 Series
This paper is based on the analysis of the industrial power distribution protection system using a simulation approach with ETAP software. The main focus is on the performance of the Overcurrent Relay (OCR) in detecting and responding to three-phase overcurrent faults in accordance with IEC 60255-151, IEEE C37series. Simulations were carried out under scenarios of normal system operation and during faults occurring at one of the buses. The results show that the OCR closest to the fault point operates first, while other relays function as backups, following the principles of selectivity and Time grading. The Time-Current Coordination Curve (TCC) indicates that the protection system operates quite selectively, although some relays experience subsequent activations due to thermal effects and residual currents. These findings emphasize the importance of adjusting OCR parameters to optimize the performance of the protection system
IMPLEMENTASI FUZZY ANALYTICAL HIERARCHY PROCESS DALAM PEMILIHAN SUPPLIER SERTA ALOKASI PESANAN BERAS MENGGUNAKAN METODE GOAL PROGRAMMING
In the face of current business competition, existing companies are competing with each other to get optimal output in order to compete with other companies. One of the steps that can be taken to be able to obtain optimal output is to choose potential suppliers in obtaining profits. This research uses the fuzzy analytical hierachy process method with the aim of knowing the priority of suppliers who will cooperate and also the goal programming method with the aim of determining the allocation of rice orders in order to minimize purchase costs, minimize the percentage of defects, maximize supplier weight and meet supply targets. The results of supplier 1, supplier 2, and supplier 3 weights are 0.3145; 0.3489; 0.3365 respectively. The goal programming method provides a better solution than the current order allocation. The total purchase cost set by the company did not decrease or increase but the total defective orders decreased by 23.43% in one year