1202 research outputs found
Sort by
Letter from American Indian child to Indian Agent Mallet
Get PDFhttps://digitalcommons.assumption.edu/mallet-manuscripts/1000/thumbnail.jp
Letter to Commissioner of Indian Affairs from Indian Agent Mallet
Get PDFhttps://digitalcommons.assumption.edu/mallet-manuscripts/1012/thumbnail.jp
Letter from Edmond Mallet in answers to memorandum
Get PDFhttps://digitalcommons.assumption.edu/mallet-manuscripts/1021/thumbnail.jp
American Indian Employees Cheyenne and Arapahoe Agency. Judges Court Indian Offices.
Get PDFhttps://digitalcommons.assumption.edu/mallet-manuscripts/1024/thumbnail.jp
Descriptive Statement of Proposed Changes in the Indian Police force
Get PDFhttps://digitalcommons.assumption.edu/mallet-manuscripts/1027/thumbnail.jp
Descriptive Statement of Proposed Changes in the Indian Police force at Cheyenne & Arapaho Agency, Indian Territory.
Get PDFhttps://digitalcommons.assumption.edu/mallet-manuscripts/1028/thumbnail.jp
2018 Undergraduate Symposium Brochure
Get PDFContains a schedule of the annual Undergraduate Symposium event as well as research abstracts for each student work.https://digitalcommons.assumption.edu/undergraduate-symposium-brochures/1007/thumbnail.jp
Ice Buckets to Proteins: Investigating the Role of matrin 3 in ALS
Get PDFAmyotrophic Lateral Sclerosis, ALS, is a neurodegenerative disease characterized by the dysfunction of motor neurons in the spinal column, which prevents muscle movements and eventually, breathing. The prognosis is death typically within 2 to 5 years with only one drug available for treatment, Riluzole. This drug can only help select ALS patients as ALS is associated with many different protein mutations. One protein frequently found in ALS patient samples is TDP-43. These samples are from stress granules that form when there is toxicity in the cell. TDP-43 has been studied in an isolated context of its RNA-Recognition Motifs, RRM. These RRM domains are approximately 90 amino acids long, typically containing 2 alpha helices and 3 beta pleated sheets. Using this information, the secondary structure of the protein can be examined. The RRMs are highly specific regions that only bind to a certain DNA sequence, RNA sequence, or protein. Having an ordered region such as the RRM, allows for probing of the folding free-energy landscape, or the conformations that the protein takes as it is denatured to an unfolded state. This landscape is studied in hopes of locating an intermediate state; a state where either the secondary or tertiary structure is maintained, even though the protein continues to unfold. This intermediate conformation would be targeted for therapeutic development with the hope of forcing proteins in this state back to a native and functioning conformation. This would decrease the amount of misfolded protein and hopefully slow stress granule formation. RNA-binding ALS-linked protein matrin 3 is typically found alongside TDP-43 in stress granules of ALS patients. MATR3 gene mutations have been associated with RNA mismanagement. Repeating the isolated experiments performed with TDP-43, matrin 3 was examined for the presence of an intermediate state. Like TDP-43, matrin 3 has 2 RRMs and a tethered complex of the two RRMs. Unlike TDP-43, an intermediate state was not found. This brings to question the biological purpose of intermediate state conformations, which is investigated here
The Role of Couples\u27 Birth Experiences in Coparenting Dynamics During the Transition to Parenthood
Get PDFPast research uncovered different antecedents, which influence the coparenting relationship including environmental supports and stressors, individual parent and child characteristics, and the couple relationship, though no prior study to date has investigated the impact of birth narratives on coparenting. The main purpose in the present study was to explore links between partners’ conjointly constructed birth narratives and coparenting dynamics preceding and following the birth of couples’ first child. Fifty-five couples’ coparenting interactions were observed during their last trimester of pregnancy (Prenatal Lausanne Trilogue Play) and at 3- (Postnatal Lausanne Trilogue play) and 12- months postpartum (Triadic play and mealtime interactions). At 3 months, couples were also asked to narrate the story of their child’s birth and of their early postpartum experience. Birth narratives were coded for narrative coherence, verbal and nonverbal emotional expressiveness, quality of coparenting, triadic capacity, and global views of the family and the coparenting relationship. Findings indicated that couples with more supportive prenatal and postpartum coparenting dynamics constructed more cohesive birth narratives at 3 months postpartum. Couples with more supportive prenatal and 3-months coparenting also expressed more positive emotions during their narratives, though these same associations were not found between positive expressiveness during birth stories and 12-months coparenting dynamics. A greater triadic focus during birth narratives was also associated with observed coparenting dynamics, though more commonly during concurrently observed interactions at 3 months rather than during prenatal or 12-months interactions. Findings suggest that birth narratives represent another paradigm which coparenting researchers should further explore to tap into the various contextual influences of coparenting across the transition to parenthood
