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Episode 3: Piña to Margarita: Tequila Edition
No full textEpisode 3 of 3 in podcast series On the Origins of Spirits. A folkloristic engagement with the historical and rhetorical elements of distilled spirits, and the traditional - never mind contemporary - tales of cultural identity that they contain
Episode 2: Freedom of Speech Does Not Mean Freedom From Consequences
No full textEpisode 2 of 3 in podcast series Cancelled. A critical deconstruction of so-called cancel culture, its historical precursors, and its present-day impacts on how we consume media, pass judgements on public figures (as well as each other), and police the content of both public communication and private conduct
2021-2022 Undergraduate Catalog
Get PDFContains course descriptions, academic calendar, directory, and related information.https://digitalcommons.assumption.edu/undergraduate-catalogs/1009/thumbnail.jp
Psychological Factors and Consumer Behavior During the COVID-19 Pandemic
Get PDFThe COVID-19 pandemic is far more than a health crisis: it has unpredictably changed our whole way of life. As suggested by the analysis of economic data on sales, this dramatic scenario has also heavily impacted individuals’ spending levels. To better understand these changes, the present study focused on consumer behavior and its psychological antecedents. Previous studies found that crises differently affect people’s willingness to buy necessities products (i.e., utilitarian shopping) and non-necessities products (i.e., hedonic shopping). Therefore, in examining whether changes in spending levels were associated with changes in consumer behavior, we adopted a fine-grained approach disentangling between necessities and non-necessities. We administered an online survey to 3833 participants (age range 18–64) during the first peak period of the contagion in Italy. Consumer behavior toward necessities was predicted by anxiety and COVID-related fear, whereas consumer behavior toward non-necessities was predicted by depression. Furthermore, consumer behavior toward necessities and non-necessities was predicted by personality traits, perceived economic stability, and self-justifications for purchasing. The present study extended our understanding of consumer behavior changes during the COVID-19 pandemic. Results could be helpful to develop marketing strategies that consider psychological factors to meet actual consumers’ needs and feelings
Belisle, Alexandre
Get PDFhttps://digitalcommons.assumption.edu/mallet-correspondence/1000/thumbnail.jp
The Evolution of Deuterium in the Pharmaceutical Industry and Its Effects on Methods of Deuterium Incorporation
Get PDFThe substitution of deuterium, an isotope of hydrogen containing one proton and one neutron, for a hydrogen has far reaching effects on the behavior of the compound. Scientists have been utilizing the effects of deuterium since 1961. The primary purpose for deuterium has been concentrated in the development of internal standards for NMR and mass spectrometers, due to their relative ‘silence’ in these studies, allowing scientists to elucidate mechanisms and trace a compound\u27s movement throughout the body. However, recently, in addition to the use of deuterium as a standard, it has been added to developing or previously created pharmaceutical compounds with the intent to stabilize the drug. This stabilization can take many forms, including decreasing the rate of metabolic breakdown, decreasing enantiomeric switching, and, in some cases, decreasing toxicity. With this more widespread application, a resurgence of studies have been completed to develop new methods of deuterating a wide variety of molecules, with a focus on common functional groups found within pharmaceutical compounds and mild reaction conditions
Opposing Immune-Metabolic Signature in Visceral Versus Subcutaneous Adipose Tissue in Patients with Adenocarcinoma of the Oesophagus and the Oesophagogastric Junction
Get PDFOesophageal adenocarcinoma (OAC) is an exemplar model of obesity-associated cancer. Previous work in our group has demonstrated that overweight/obese OAC patients have better responses to neoadjuvant therapy, but the underlying mechanisms are unknown. Unravelling the immune–metabolic signatures of adipose tissue may provide insight for this observation. We hypothesised that different metabolic pathways predominate in visceral (VAT) and subcutaneous adipose tissue (SAT) and inflammatory secretions will differ between the fat depots. Real-time ex vivo metabolic profiles of VAT and SAT from 12 OAC patients were analysed. These samples were screened for the secretion of 54 inflammatory mediators, and data were correlated with patient body composition. Oxidative phosphorylation (OXPHOS) was significantly higher in VAT when compared to SAT. OXPHOS was significantly higher in the SAT of patients receiving neoadjuvant treatment. VEGF-A, VEGF-C, P1GF, Flt-1, bFGF, IL-15, IL-16, IL-17A, CRP, SAA, ICAM-1, VCAM-1, IL-2, IL-13, IFN-γ, and MIP-1β secretions were significantly higher from VAT than SAT. Higher levels of bFGF, Eotaxin-3, and TNF-α were secreted from the VAT of obese patients, while higher levels of IL-23 and TARC were secreted from the SAT of obese patients. The angiogenic factors, bFGF and VEGF-C, correlated with visceral fat area. Levels of OXPHOS are higher in VAT than SAT. Angiogenic, vascular injury and inflammatory cytokines are elevated in VAT versus SAT, indicating that VAT may promote inflammation, linked to regulating treatment response
