Alberto Sols Biomedical Research Institute
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Blanca Catalán de Ocón’s notebook. Memoir of a naturalist who connected botany, arts and poetry
No full textLa botánica Blanca Catalán de Ocón y Gayolá (1860-1904) vivió su juventud rodeada de la belleza
de la naturaleza, el saber científico y el gusto la poesía que se respiraba en cada rincón de su hogar;
un inmenso valle en el corazón de la Sierra de Albarracín. Elaboró un detallado herbario con más de
ochenta especies, algunas desconocidas para la ciencia. Sin embargo, la naturaleza fue para ella mucho
más que un elemento a analizar científicamente. Se convirtió en fuente de inspiración, manifestada
en poemas y composiciones florales. En este trabajo examinamos su herbario y archivo personal,
reflexionando sobre las prácticas que vincularon las artes y la botánica como estrategia para crear
espacios alternativos de discusión científic
Chemical characterization and oxidative status of olive oils extracted by expeller pressing and supercritical CO2 extraction: impact on quality standards and their regulatory recognition
No full textInnovative extraction methods, such as the sequential combination of expeller pressing and supercritical CO₂ (SC- CO₂), were applied to obtain high quality olive oil (OO) while improving sustainability and reducing environmental impact. In this study, the physicochemical properties of the oils obtained at the Spanish Association for Standardization and Certification were evaluated following the quality standards established by the European Union and the International Olive Council. The results revealed that the combined yield of the sequential process was 87 %, significantly higher than centrifugation-based extraction methods, which typically yield around 75–80 %. The oils showed high phenolic concentrations (1013–1855 mg/kg), and superior oxidative stability, underlining their potential for functional and premium market applications. Acidity and peroxide values are lower than those established for virgin olive oil. However, some parameters (e.g., K 232 and K ) exceeded these limits, probably due to the unique extraction processes employed. These results highlight the need to update regulations to include new extraction methods and validate these oils as high-value sustainable productsSome authors acknowledge financial support from Ministerio de Ciencia, e Innovación y Universidades (project number PID2020-119084RB-C21
The Late Antique double-handled bottles T15.5: regarding the funerary trousseau from tomb 4 of the church of El Rebollar (El Boalo)
No full textEl análisis de la botella de dos asas localizada en el interior de la tumba 4 de la iglesia tardoantigua de
El Rebollar (El Boalo, Madrid) nos permite confirmar la cronología de este tipo de recipientes al estar asociada a
un individuo, cuya datación radiocarbónica permite encuadrarla entre la segunda mitad del siglo VII d. C. e inicios
del VIII d. C. Se confirma así la fecha que se le ha asignado a estas botellas de dos asas categorizadas por Gutiérrez
Lloret como la forma T.15.5. En este estudio se analizan también los ejemplares que se adscriben a este tipo y que
se han documentado hasta el momento en la península ibéricaThe analysis of the double-handled bottle located inside tomb 4 of the Late ancient church of El
Rebollar (El Boalo, Madrid) allows us to confirm the chronology of this type of vessels. It is associated with
an individual whose radiocarbon dating allows frame it between the second half of the 7th century and early 8th
century AD. This confirms the date assigned to these double-handled bottles categorized by Gutiérrez Lloret as
type T.15.5. This study also analyses the bottles that are assigned to this type and that have been documented to
date in the Iberian PeninsulaEste trabajo se enmarca en la línea de investigación
del Proyecto de Transferencia Heritage for all:
citizen participation and social innovation. Convenio
UAM-BOCEMA para la internalización de un proyecto
modélico de Arqueología de Público (nº 465061),
dirigido por Javier Salido Domínguez (UAM) y financiado
por el municipio de El Boalo, Cerceda y Mataelpino
y la Fundación de la Universidad Autónoma de
Madrid a través de la firma de un convenio. También
se ha realizado en el marco del OPEN LAB Heritage
for all: citizen participation and social innovation de
la Alianza Europea CIVIS, dirigido por Javier Salido
Domíngue
Assessing vocabulary acquisition using a fast-mapping task in an Android application: A pilot study
No full textPurpose: The aim of this study was to explore whether a fast mapping task embedded in an Android application (FastMApp) is a valid tool to assess referent selection abilities in Spanish-speaking children aged between 18 and 30 months. Traditional assessment tools for lexical development use static quantitative methods that assign children a final score to represent their overall vocabulary level. These methods fail to provide insights into the learning process, despite their potential relevance for clinical and educational purposes. Method: Sixty Spanish-speaking children participated in this study. They completed the FastMApp (a 22-trials’ fast mapping noun task including 4- and 5-item trials, with one unknown object), and their caregivers rated their child’s vocabulary on a parent-rated vocabulary inventory measure. Result: The data show a high percentage of responses to the task, indicating that the children were actively complied with the task. The scores for known labels are significantly higher compared to unknown labels, and the scores for 4-item trials are significantly higher compared to 5-item trials. We observed a strong and significant relationship between the scores in this task and the scores on the parent-rated vocabulary inventory measure. Conclusion: The results suggest that FastMApp is suitable for assessing early vocabulary acquisition in Spanish-speaking childrenThis research is funded by FEDER, Ministerio de Ciencia, Innovación y Universidades, Agencia Estatal de Investigación, Project PID2021-123907NB-I0
Infrared emitting lanthanide doped nanoparticles provide sensing capabilities to coronary implants
No full textIntracoronary stents have revolutionized the treatment of coronary obstructions, allowing for minimally
invasive procedures and significantly enhancing both therapeutic efficacy and patient quality of life.
Despite their clinical success, once implanted, stents act as passive elements, incapable of providing
real-time data on the treated artery, thereby limiting early diagnosis of post-implantation
complications such as inflammation, restenosis, or recurrence of atheromatous plaques. In this study,
we introduce stents with deep tissue sensing capabilities through the incorporation of near-infrared
emitting lanthanide-doped nanoparticles. Using 3D printed stent prototypes, we demonstrate that the
luminescence emitted by neodymium and ytterbium ions in core/shell/shell NaYF₄ nanoparticles
facilitates both deep tissue visualization and tracking of the stent position. Additionally, the
temperature-dependent fluorescence lifetime of Nd,Yb:NaYF₄ nanoparticles provides thermal
sensitivity, allowing precise deep tissue thermal monitoring of catheter-induced heating with subdegree
accuracy. This work highlights the potential of infrared-emitting nanoparticles to drive the next
generation of coronary stents, paving the way for advanced light-based diagnostics and therapeutic
proceduresThis work was supported by Grant PID2023-146775OB-I00 (INCLINA) and Grant PID2021-123318OB-I00(NANOGRANZ) funded by MCIN/AEI/
10.13039/501100011033 and the European Regional Development Fund (ERDF). Dongmei Qiu acknowledges the scholarship from China Scholarship
Council (No.202308330053). Juan Pedro Cascales acknowledges support from the Comunidad de Madrid, Spain, through an “Atracción de
Talento Investigador” fellowship (2022-T1/BMD-23751). Jose Marques-Hueso thanks the Spanish Ministerio de Universidades for support through
the program Beatriz Galindo (Award BG22/00128
Evolución de los planes de protección pública a la vivienda y efectos del reparto de competencias
No full textSe estudia la evolución de los planes estatales de vivienda, estableciendo cuatro etapas. Asimismo, se analiza la coexistencia entre los planes estatales y autonómicos de vivienda y los efectos jurídicos. Finalmente, se estudia los efectos de la Ley estatal de vivienda sobre la planificación en materia de vivienda, tanto estatal como autonómicaThe evolution of state housing plans is studied, establishing four stages. It also analyses the coexistence between state and regional housing plans and their legal effects. Finally, the effects of the State Housing Act on housing planning, both at state and autonomous community level, are studie
Exploring the broad-spectrum activity of carbohydrate-based Iberin analogues: From anticancer effect to antioxidant properties
No full textIberin is a lower homologue of sulforaphane (SFN) which has shown effectiveness in addressing various pathologies, including its anti-inflammatory properties, antitumor activity against various cancers, and antimicrobial effects. Building on this activity, a series of carbohydrate-based analogues of the natural isothiocyanate (ITC) iberin were synthesized, and their anticancer and antioxidant activities were evaluated. Cytotoxicity studies on three cancer cell lines using Resazurin assay demonstrated significant cytotoxic activity, particularly against bladder cancer. The sulfonyl derivatives exhibited the most potent effects, with IC50 values comparable to those of reference natural isothiocyanates (from 10 to 20 μM). Computational simulations support the hypothesis that carbohydrate-based ITCs can interact with STAT3's SH2 domain in a manner similar to SFN, laying the groundwork for their potential development as STAT3-targeted anticancer agents. The antioxidant potential of these compounds was assessed by their ability to activate the Nrf2 factor, yielding CD values (concentration required to double luciferase activity compared to basal conditions) between 1.55 and 10.36 μM, without cytotoxicity at these concentrations. Notably, the phenylsulfone derivative 22β displayed slightly higher or comparable antioxidant activity to that of natural isothiocyanates. Based on these findings, this phenylsulfone analogue was selected as the optimal compound due to its dual anticancer and antioxidant activities. An additional advantage of this carbohydrate-based ITC is that it is a solid compound, making it easier to handle than natural isothiocyanates, which are typically liquidsThis work was supported by the Ministerio de Ciencia, Innovación y Universidades (grant number PDC2022-133627-I00, cofinanced by MCIN/AEI/10.13039/501100011033 and the european Union “NextGenerationEU”/PRTR, and grant number PID2022-138863OB-I00, financed by MCIN/AEI/10.13039/501100011033/FEDER, EU). The US (University of Seville) is also acknowledged for the support provided through its own research plan (VII PPIT-US). We gratefully thank the Centre of Research Technology and Innovation of the University of Seville (CITIUS) for NMR facilities. The authors would like to thank the "X-Ray Diffraction Service" at the Instituto de Investigaciones Químicas" (CSIC) and Dr. F. Fernandez de Cordova for his assistance in acquiring the X-ray data and his guidance in the resolution proces
Towards the integration of nanoscale heating effects in magnetic hyperthermia treatment planning
No full textTesis Doctoral inédita cotutelada por la Ghent University y la Universidad Autónoma de Madrid, Faculta de Ciencias, Departamento de Física Teórica. Fecha de Lectura: 30-06-2025Thank you to the founders of this project. To the Spanish Ministry of Science, Innovation under Contract no. PEJ2018-004866-A, as well as support under grant PID2020-117544RBI00, CEX2020-001039-S, and RED2018-102626-T funded by MCIN/AEI/ 10.13039/501100011033, and grant RYC2018-025253-I funded by MCIN/AEI/ 10.13039/501100011033 and by “FEDER A way of making Europe”. I also want to thank the VSC (Flemish Supercomputer Center), funded by Ghent University, FWO, and the Flemish Government – department EWI. And Systems Unit of the Information Systems Area of the University of Cádiz for computer resources and technical suppor
Principles for supporting and accompanying the development of early mathematical intuitions from 0 to 3 years
No full textPlanteamos principios para orientar la acción educativa, la creación de entornos y propuestas, y el acompañamiento, para facilitar el despertar y el desarrollo de las primeras intuiciones matemáticas desde el nacimiento a los 3 años. Para ello, nos basamos en las investigaciones en Educación Matemática en el ciclo de 0-3, y en una cultura de la Infancia basada en la escucha y en la sensibilidad hacia el desarrollo global infantil. Partiendo de una concepción de la actividad matemática adecuada para estas edades, explicamos en qué momentos, y desde qué presupuestos, pueden los profesionales del 0-3 facilitar mejor la educación matemáticaWe propose principles to guide educational action, the creation of environments and proposals, and support to facilitate the awakening and development of early mathematical intuitions, from birth to age 3. To do so, we draw on research in Mathematics Education in the 0-3 cycle and on a Culture of Childhood based on listening and sensitivity to children's overall development. Starting from a conception of mathematical activity appropriate for these ages, we explain which moments, and from what premises, 0-3 professionals can best facilitate mathematics educatio
Evaluating Earth Construction Techniques on Ancient Architecture: An Exploratory Use of Empirical Field Tests in West Asia (Tell Zurghul/Nigin)
No full textThe research empirically evaluates ancient earth construction techniques through the analysis of archaeological adobe samples from Tell Zurghul/Nigin, south-eastern Iraq, dating from the mid-5th to mid-3rd millennium BCE. Simple, non-standardised empirical field tests were employed to obtain preliminary material characterisations, valuable for pilot assessments and gaining further significance when compared with quantitative analytical results. Their application evaluates the functionality of these tests while integrating archaeological insights with material science, underscoring the importance of multidisciplinary collaboration in earthen heritage conservation. Sixteen samples—fifteen archaeological and one modern—were analysed to assess raw material composition, grain size, clay behaviour, organic content, cohesion in wet and dry states, and surface adhesion. Results demonstrate notable homogeneity in material composition across the time span, primarily fine sands with minimal clay or silt. This suggests favourable drainage, minimal shrinkage, and reduced cracking but limited cohesion, implying a potential need for stabilisers such as plastic clays or fibres in construction. These findings inform conservative strategies for the preservation and restoration of earthen structures at the sit