Fukuyama University Repository / 福山大学学術情報リポジトリ
Not a member yet
4096 research outputs found
Sort by
TSG101, a tumor susceptibility gene, bidirectionally modulates cell invasion through regulating MMP-9 mRNA expression.
Get PDFTumor susceptibility gene 101 (TSG101) was initially identified in fibroblasts as a tumor suppressor gene but subsequent studies show that TSG101 also functions as a tumor-enhancing gene in some epithelial tumor cells. Although previous studies have unraveled diverse biological functions of TSG101, the precise mechanism by which TSG101 is involved in carcinogenesis and tumor progression in a bidirectional and multifaceted manner remains unclear.To reveal the mechanism underlying bidirectional modulation of cell invasion by TSG101, we used RNA interference to examine whether TSG101 depletion bidirectionally modulated matrix metalloproteinase (MMP)-9 expression in different cell types.TSG101 depletion promoted cell invasion of HT1080 cells but contrarily reduced cell invasion of HeLaS3 cells. In HT1080 cells, TSG101 depletion increased both baseline and phorbol 12-myristate 13-acetate (PMA)-induced MMP-9 secretion through enhancing MMP-9 mRNA expression, but did not affect the expression or activation of MMP-2. In contrast, TSG101 depletion decreased PMA-induced MMP-9 secretion through reducing MMP-9 mRNA expression in HeLaS3 cells. TSG101 depletion had little impact on the signaling pathways required for the activation of transcription of MMP-9 or MMP-9 mRNA stability in either cell line.TSG101 bidirectionally modulates cell invasion through regulating MMP-9 mRNA expression in different cell types. Our results provide a mechanistic context for the role of TSG101 in cell invasion as a multifaceted gene.Tumor susceptibility gene 101 (TSG101) was initially identified in fibroblasts as a tumor suppressor gene but subsequent studies show that TSG101 also functions as a tumor-enhancing gene in some epithelial tumor cells. Although previous studies have unraveled diverse biological functions of TSG101, the precise mechanism by which TSG101 is involved in carcinogenesis and tumor progression in a bidirectional and multifaceted manner remains unclear.To reveal the mechanism underlying bidirectional modulation of cell invasion by TSG101, we used RNA interference to examine whether TSG101 depletion bidirectionally modulated matrix metalloproteinase (MMP)-9 expression in different cell types.TSG101 depletion promoted cell invasion of HT1080 cells but contrarily reduced cell invasion of HeLaS3 cells. In HT1080 cells, TSG101 depletion increased both baseline and phorbol 12-myristate 13-acetate (PMA)-induced MMP-9 secretion through enhancing MMP-9 mRNA expression, but did not affect the expression or activation of MMP-2. In contrast, TSG101 depletion decreased PMA-induced MMP-9 secretion through reducing MMP-9 mRNA expression in HeLaS3 cells. TSG101 depletion had little impact on the signaling pathways required for the activation of transcription of MMP-9 or MMP-9 mRNA stability in either cell line.TSG101 bidirectionally modulates cell invasion through regulating MMP-9 mRNA expression in different cell types. Our results provide a mechanistic context for the role of TSG101 in cell invasion as a multifaceted gene.departmental bulletin pape
The International Peacebuilding and Security : Justice and International Politics
Get PDFdepartmental bulletin pape
University Entrance Examinations in Thailand - Equity within “Boon tham kam taeng”
Get PDFIntense competition in university entrance is a defining characteristic of higher education in many countries, especially those that are affected with diploma disease.
Thailand is no exception.
Luxurious cram schools, rongrian kuat wicha, are pervasive and overflow the country.
This paper aims to describe the current university entrance examination in Thailand by analyzing related documents and supplementary interviews with stakeholders.
The analysis shows that, in university entrance examination, much more opportunities are provided for those who have than those who do not have.
Such inequity in entrance examination in Thailand can be understood by the concept “Boon tham kam taeng” which means “your current status is due to your karma.”departmental bulletin pape
Synthetic Studies of Bioactive Heterocyclic Natural Products and Fused Heterocyclic Compounds Based on the Thermal Electrocyclic or Azaelectocyclic Reaction of 6π-Electron or Aza-6π-electron Systems
Get PDFdepartmental bulletin pape
Chiral Recognition of Diketopiperazines Cyclo(Pro-Gly) Using (-)-Epigallocatechin-3-O-gallate
Get PDFdepartmental bulletin pape
New Total Synthesis of the neuronal Cell-Protecting Carbazole Alkaloids Carbazomadurin A and (S)-(+)-Carbazomadurin B
Get PDFdepartmental bulletin pape
A Study of the impact on the traditional society by tourism development in Bali
Get PDF40020398837地上の楽園と呼ばれるバリ島には海外・国内から毎年多くの観光客が訪れている。バリ島の魅力は典型的なリゾートのイメージだけではなく、ヒンドゥー教に根ざした伝統文化にあり、多くの人々が「神々の住む島」バリに魅了される。観光開発が進む中で、バリ島は環境問題等多くの問題を抱えながらも、バリの人々は「世界的観光地バリ」を誇りにし、観光と伝統文化は相互の発展に寄与しあっている。本稿では観光開発がバリ社会にどのような影響を与えているのか、バリの人々の伝統文化や社会慣習に対する意識はどのように変化しているのかを調査・分析している。"A magical paradise"―Bali Island attracts a large number of tourists from both overseas and domestic market. It is attractive not only for its typical resort image but also because of its traditional culture based on Balinese Hinduism. Many tourists have been fascinated with "The Island of the gods". While tourism development advances and some environmental problems occur, the Balinese people enjoy the reputation as a prominent tourist destination. Moreover, tourism and vibrant culture are interacting harmoniously in order to develop Balinese society.
This paper aims to explore how tourism development concerns Balinese society and how the traditional values of Balinese culture changed in recent years.departmental bulletin pape
