International Journal of Ayurvedic Medicine
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Comparative Standardisation Study of a Siddha Source Herb Acalypha indica Linn. Aerial Parts and Marketed Raw Material - An Insight to Develop Monograph
Get PDFBackground: Acalypha indica Linn.(AI) is a herbaceous annual catkin-like inflorescences belonging to the Euphorbiaceae family. AI has a wide range of therapeutic effects including laxative properties, anthelmintic, wound healing, antiseptic etc. Objectives: This study was to carry out the comparative standardisation study for a siddha source herb Acalypha indica(Linn) aerial parts and marketed raw material by collection and authentication of aerial parts of AI and to evaluate the physicochemical constants such as LOD, ash values, extractive values as per the standard methods. Materials and Methods: The preparation of hydro alcoholic and ethyl acetate extract was carried out by cold maceration extraction procedure for both fresh leaves and raw material of AI. Results: The preliminary physicochemical screening tests, quantitative determination of total flavonoid and phenolic contents, hydrogel preparation of AI was carried out. The HPTLC finger printing for ethyl acetate extract of fresh leaf was developed in comparison with three standards Quercetin, Gallic acid and Beta sitosterol and were scanned under UV light at 397nm, 280nm, 580nm respectively. The number of peaks obtained in AI extract were observed to be 3, 8 and 28 respectively. Pesticide analysis regulations often require chemical testing using confirmatory techniques such as GC/MS and about 26 compounds were identified under suitable gas chromatographic conditions. Conclusion: The presence of phytoconstituents were analyzed and the studies were performed to aid further investigations for the identification of therapeutic value
Cutaneous Adverse Drug Reactions on application of Nagaradi Lepa - A Retrospective analysis
Get PDFIntroduction: Cutaneous adverse drug reactions are among the most common types of drug hypersensitivity reactions. Although considered natural and safe, Ayurveda medicines can cause adverse reactions. This article highlights the cases of cutaneous adverse drug reactions possibly due to external application of Nagaradi lepa. Materials and Methods: This is an observational, retrospective and record based study conducted by analyzing the spontaneous reported ADR forms, caused by the external application of Nagaradi lepa, collected over a period of 12 months (April 2022 to March 2023) at Peripheral Pharmacovigilance Centre, VPSV Ayurveda College Kottakkal, Kerala. Results: During the period of one year, 3 cutaneous ADRs were reported due to external application of Nagaradi lepa. All the 3 cases fall under the category of Probable according to Naranjo’s ADR Probability scale. 2 cases were mild and 1 case was moderate in severity. All the 3 cases were recovered from ADR. Conclusion: Though under reporting, we may have to consider the possibility of Ayurvedic drugs to cause adverse drug reactions. Pharmacovigilance is an ongoing and continuous process. Reporting of ADR to Pharmacovigilance centers help to generate information on ADR related Ayurvedic formulations and also to prevent its recurrence.
Role of Sheeta Upanaha in the Management of Vipadika – A Case Study
Get PDFSkin is the mirror which reflects the harmony of Internal functions of body. Psoriasis is a non-infective inflammatory, Proliferative, Chronic skin disease in which there are scaly papules and plaques that can involve any part of body. Palmoplantar psoriasis refers to psoriasis that develops on palms and soles. Vipadika is included in Kshudra kusta having sign and symptoms similar to Palmoplantar psoriasis. In this case study, A 65-year-old male patient a known case of Palmoplantar psoriasis approached with symptoms of Scales and fissures over both palms and soles with Pain, Severe itching and burning sensation for the past 1year. After clinical examination and history of the patient he was advised, Deepana & Pachana, Shamana Snehapana and Seetha Upanaha as module of treatment. Even though treatment principles such as Deepana, Pachana, Shamana Snehapana might have helped in the overall result, but it was Seetha Upanaha Chikitsa observed to be quite significant in this case, as patient started feeling better after starting of Seetha upanaha. After implementation of treatment plan patient has become completely symptom free and there was no recurrence even after six months.
Insilico Studies Unveiling the Hepatoprotective Potential of Morus alba Linn: Docking and ADMET Analysis
Get PDFThe goal of the drug discovery process is to search for new drug molecules which can bind to a specific target known to be involved in causing a disease. This study aims to identify potential inhibitors against the TGF-β-type-I receptor (PDB Id-1VJY) by developing ligands through molecular docking and ADMET-based virtual screening. The plant-based nature product database of Morus alba Linn is utilized for this purpose. The resultants hits, identified as actives were evaluated by molecular docking studies to get insight into their potential binding interaction with the target protein. 1-deoxynojirimycin (A1), Catechin (A2), Cyanidine-3-rutinoside (A3), Cyclomulberrin (A4), Kaempferol (A5), Kuwanon-G (A6), Morusin (A7), Mulberrin (A8), Mulberrofuran-G (A9), Quercetin-3-(6-malonylglucoside) (A10), Quercitrin (A11), Rutin (A12), were selected for the molecular docking.ADMET based virtual screening ligand/Compound (A1, A2, A4, A5, A7, A8, A9) passes the lipinski’s rule. Compound A4 (-10.7 kcal/mol), A5 (-10.4 kcal/mol) and A8 (-9.9 kcal/mol) had the highest binding affinity to the active site in TGF-β-type-I receptor. In conclusion, based on docking score and ADMET virtual screening, Cyclomulberrine (A4) (-10.7 kcal/mol) more affinity toward the TGF-β-type-I receptor that could be investigated further in the search for Hepatoprotective agent.
A Comparative Study of Yogic Practices and Diet Therapy in the Management of Pre-Diabetes wsr to Glycemic Control: A Case Report
Get PDFPre-Diabetes is growing with an alarming rate all over the world. It is a clinical entity between the normoglycemia and stage of Type II Diabetes mellitus. Faulty dietary habits and lifestyle errors play a key role in the pathophysilogy of Pre-diabetes. Pre-diabetics have higher risk for cardiovascular diseases, fatty liver, kidney failure and other associated complications of diabetes. The reason for the rising incidence of Pre-diabetes is due to the lack of public awareness, observation, follow-up programs and self-awareness about the conditions of disease. This report is about a case of successful reversal of Pre-diabetes to normal stage through Yogic practices and diet therapy. The selected patient was prescribed Yogic practices and diet therapy throughout the intervention. The trial patient reported glycosylated (HbA1c) as high as 5.9 % and after the intervention of Yogic practice and diet therapy, it was reduced to 5.2%. After three months intervention, fasting blood sugar dropped from 110 mg/dl to 90 mg/dl and postprandial blood sugar dropped from 165 mg/dl to 132 mg/dl and Weight reduced from 93 kgs to 90 kgs. He was responded well in terms of clinical symptoms of Pre-diabetes after the completion of trial intervention. Besides, no other lifestyle modification interventions were enforced during the whole trial period. The results concluded that consistent diet therapy and regular Yogic practice can not only maintain the blood sugar levels in patient of Pre-diabetic but also improve the patient general health and wellbeing
Study of the effect of Kalyani raga in Anxiety-like conditions in female Wistar rats
Get PDFStress is a medical condition. It can be managed without any internal interventions through Raga therapy as it is healing therapy. It works effectively in psychological conditions if performed with particular harmony. To study the effect of Kalyani raga on the behavioral pattern of female Wistar rats, stress and anxiety were induced in rats with mild stressors. Effects were recorded, compared, and analyzed. In 10 days pilot study, we studied two groups of 10 female Wistar rats in which mild stressors were induced for 7 days before 2 days and post-study 1-day observation. In group one, we intervened with Kalyani Raga and observed the behavioral pattern while another group was observed for the same without any intervention. The observation was recorded by a high-quality video camera. Parameters studied were locomotion, Climbing on the cage, Digging, Sitting, Feeding, Drinking, defecation, sleeping, and rubbing. Both groups were exposed to mild stressors during the recording. Kalyani Raga activates neurons and remarkably engages the brain. Even after stressors, Improvement in feeding within group 1 and the gross motor activities of group 1 with the intervention of Kalyani raga have been seen by a decrease in locomotion, digging, rubbing, and an increase in sleep showing the soothing effect of Kalyani raga which also showed a significant effect on sleep despite stress as compared to group 2 with no intervention. There is huge scope to perform the same study with a large sample size to get the evidence that can prove the effect of Kalyani raga in stressful conditions
Efficacy of Jatyadi Kwatha Gandusha in Management of Pittaja Mukhapaka with special reference to Aphthous Ulcer: A Randomized Controlled Clinical Trial
Get PDFThe condition known as Pittaja Mukhapaka is frequently encountered by patients seeking treatment at the outpatient department of the Ears, Nose, and Throat department. This condition is characterized by inflammation, ulceration, and a burning sensation in the oral mucosa, and is often associated with Aphthous ulcers (Pittaja Mukhapaka). Although modern medicine has several treatment options, including anti-inflammatory drugs, topical corticosteroids, and topical tetracyclines, these treatments have limitations. In contrast, Jatyadi Kwath Churna is a traditional polyherbal composition in ayurvedic medicine that has been used to treat oral problems for centuries. This herbal preparation contains Jati Patra, Guduchi, Draksha, Daru Haridra, Yavasa, Haritaki, Vibhitaki, Madhu, and Amlaki, and is indicated for oral problems in the texts Yogaratnakara and Bhaishajya Ratnavali. Material and Methods: This study aims to evaluate the efficacy of Jatyadi Kwatha Gandusha for Mukha Rogas, a study was conducted with 30 subjects randomly allocated to either Group A (receiving Gandusha of Jatyadi Kwatha and Madhu) or Group B (receiving Triphala Kwatha). Result: Both groups experienced complete relief from discomfort, burning sensations, and excessive salivation, on analysis between the groups with a statistically significant p-value results are equally effective in both groups. Conclusion: The study successfully demonstrated the effectiveness of Jatyadi Kwatha Gandusha and Triphala Kwatha in managing Pittaja Mukhapaka
Efficacy of Aparajit avaleha in Vataja Kasa in children
Get PDFBackground: In Ayurved classics Kasa is describes as a disease entity rather than a symptom. Many Respiratory Tract disorders can be incorporated under the broad umbrella of Kasa. Vataja Kasa which is characterized by Shuska mukha and gala, Shuska Kasa with Shuska alpa kapha, Swarbheda, Parshva Shool, Shira shool, Urashool, Daurbalya. It can be correlated symptomatically with Dry cough having sign and symptoms as Dry Cough, Coughing with small quantity of expectorant, Shortness of breath, Weakness, Soreness and dryness of throat, Heartburn, Pain in flank region, Dryness of mouth, Hoarseness of voice. Though it is not life threatening it impacts daily routine, work capacity as well as growth and development of a child. Aim and Objectives: To assess the efficacy of Aparajit Avaleha in the management of Vataja Kasa in Children and to study the probable mode of action of Aparajit Avaleha in management of Vataja Kasa. Materials and Methodology: In this study, total 30 patients of Vataja Kasa were included between 6 years to 12 years. The included patients were treated with Aparajit Avaleha described in Chakradutta thrice a day for 14 days with lukewarm water. The assessment was done on the basis of subjective as well as objective parameters. Results: Aparajit Avaleha showed statistically significant improvement in the subjective parameters as well as on objective parameters as most of the drugs possess pharmacological activities as Anti-inflammatory, Anti- asthmatic, Antibacterial, Antispasmodic, Immuno-stimulator, Anti-allergic, Anti- histaminic and Anti-pyretic. Conclusion: Aparajit Avaleha is effective in the management of Vataja Kasa in children.
Determination of Minimal Inhibitory Concentration of Gel containing combination of Picrorhiza Kurroa and Ficus Benghalensis for Treatment of Periodontitis
Get PDFBackground: The therapeutic effects of Picrorhiza kurroa Royle ex benth and Ficus benghalensis L. for treatment of chronic inflammatory diseases is well known. Objective: The purpose of the present study is assessment of the efficacy of gel containing combination of Picrorhiza kurroa Royle ex benth and Ficus benghalensis L. against periodontopathogens and hydroalcoholic extracts of Picrorhiza kurroa Royle ex benth (PK) and Ficus benghalensis L. (FB) against periodontopathogens. Material & Methods: The preparation of the herbal Water extracts, Alcohol extracts and Hydro Alcoholic extracts was done by Soxhlet extraction method. MIC of different extracts of PK and FB and its combination was determined. Results: The MIC of the PK water extract against Aggregatibacter actinomycetemcomitans (Aa) and Porphyromonas gingivalis (Pg) was 0.8 μg/ml. For Aa and Pg, the MIC of water extract of FB was 1.6 μg/ml and 6.25 μg/ml, respectively. The combination of PK and FB alcoholic extract was shown to have a MIC of 1.6 μg/ml. Conclusion: The presence of antibacterial activity could be confirmed in periodontopathogens species which were assayed in this study. However, the MIC for the species employed showed a very large range, and were mostly very high. Nevertheless, traditional knowledge might provide some leads to elucidate potential candidates for future development of new antibiotic agents
Investigating the Prevalence of Stress and its Relationship with Sleep Quality in University Students: A Study in Iran
Get PDFIntroduction: Students are willing to cut back on sleep in order to adapt and cope with their stressful work load and environment. This study examines the prevalence of stress and its relationship with sleep quality. Methods: This cross-sectional study was conducted using available sampling of male and female students of the Nursing and Midwifery Faculty of Jundishapur University of Medical Sciences, Ahvaz in 2022. Pittsburgh Sleep Quality Questionnaire was used to measure sleep quality and Kessler Psychological Distress Scale Questionnaire was used to measure stress. Results: The prevalence of all levels of stress among students was 53.2% (140 people). 61 people (23.2%) experienced mild stress, 35 students (13.3%) experienced moderate stress, and 44 students (16.7%) experienced severe stress. The average score of Kessler\u27s psychological distress (K10) of the participants was 21.9 ± 7.3 (maximum = 50). No significant relationship was observed between stress and gender (p=0.25) and academic year (p=0.72). There was a statistically significant relationship between sleep quality and stress (p < 0.001). Conclusion: This study reports the high prevalence of stress and poor sleep quality in students of Ahvaz College of Nursing and Midwifery. This study shows a strong connection between sleep quality and stress