Texas Digital Library
UT Southwestern Medical Center Institutional Repository (University of Texas)Not a member yet
10274 research outputs found
Sort by
Why I Work
Get PDFThe author submitted this entry in the Open Verse Poetry category (Amateur division) for the 2023 On My Own Time (OMOT) Art Show.I am close to retirement, and it scares me
Words
Get PDFThe author submitted this entry in the 10-Word Story category (Amateur division) for the 2023 On My Own Time (OMOT) Art Show.I had a lot of words and ideas. The hard part was just putting it down on paper
Only Six
Get PDFThe author submitted this entry in the Open Verse Poetry category (Professional division) for the 2023 On My Own Time (OMOT) Art Show.This work received a First Place Award in the "Open Verse Poetry" category from all literary works submitted in the 2023 On My Own Time show.The Allen outlet mall shooting hit close to home for me not just because it was in DFW, but also because I was present during a shootout at Irving Mall when I was a child (my family was in a different part of the mall). Then I learned about one of the survivors, six-year-old William Cho who lost his family. This poem came out of remembering that I had been six years old
Arm squeeze, ischemic preconditioning and more on the horizon
Get PDFDetailed formal protocol with illustrations and extensive bibliography.A recording of the protocol presentation is available on UT Southwestern's Mediasite. Note: Access to the video is restricted to authorized UT Southwestern users only.UT Southwestern--Internal Medicin
Minimally invasive treatment options for benign thyroid nodules
Get PDFDetailed formal protocol with illustrations and extensive bibliography.A recording of the protocol presentation is available on UT Southwestern's Mediasite. Note: Access to the video is restricted to authorized UT Southwestern users only.UT Southwestern--Internal Medicin
Physiology and Circuitry of Bile Acid Detection Within the Accessory Olfactory System
Get PDFPages 1-18 are misnumbered as pages 2-19.The mouse accessory olfactory system (AOS) supports social and reproductive behavior through the sensation of environmental chemosignals. These chemosensory cues provide a vast amount of information that the olfactory systems must then encode and translate into behaviorally relevant outputs. The initial detection of olfactory stimuli in the accessory olfactory system (AOS) is mediated by the vomeronasal sensory neurons (VSNs) in the vomeronasal organ (VNO), which relay the signals to the accessory olfactory bulb (AOB). Impaired vomeronasal signaling results in deficits in social communication and other behaviors. Despite decades of research, our understanding of how odors are encoded and processed within the AOS is still severely limited. For example, the extent to which the AOS discriminates and encodes chemosensory information at the peripheral level of the VNO is currently unknown. Furthermore, how the tuning of VSNs is then translated into a behaviorally relevant representation in the brain is still unclear. Understanding how the AOS processes and encodes chemosensory information will advance our understanding of how external cues can generate internal chemosensory representations that are critical for survival.
Sensory adaptation is a source of experience-dependent feedback that impacts responses to environmental cues. In the mammalian main olfactory system (MOS), adaptation influences sensory coding at its earliest processing stages. However, sensory adaptation in the accessory olfactory system (AOS) remains relatively controversial, leaving many aspects of the phenomenon unclear. Thus, I investigated sensory adaptation in vomeronasal sensory neurons (VSNs) using in situ Ca2+ imaging. I found evidence for sensory adaptation in response to the monomolecular ligands, cholic acid (CA) and deoxycholic acid (DCA). These Ca2+ imaging experiments also revealed the presence of a slower form of VSN adaptation that accumulated over dozens of stimulus presentations delivered over tens of minutes. These studies help establish the presence of VSN sensory adaptation and provide a foundation for future inquiries into the molecular and cellular mechanisms of this phenomenon and its impact on mammalian behavior.
A growing number of excreted steroids have been shown to be potent AOS cues, including bile acids (BAs) found in feces. As is still the case with most AOS ligands, the specific receptors used by vomeronasal sensory neurons (VSNs) to detect BAs remain unknown. To identify VSN BA receptors, we first performed a deep analysis of VSN BA tuning using volumetric GCaMP6f/s Ca2+ imaging. These experiments revealed multiple distinct populations of BA-receptive VSNs with submicromolar sensitivities. I then developed a new physiology-forward approach for identifying AOS ligand-receptor interactions, which I term Fluorescence Live Imaging for Cell Capture and RNA sequencing, or FLICCR-seq. FLICCR-seq analysis revealed five specific V1R family receptors enriched in BA-sensitive VSNs. These studies introduce a powerful new approach for ligand-receptor matching and reveal biological mechanisms underlying mammalian BA chemosensation.
Finally, I've spent the remainder of my thesis laying the groundwork for exploring BA-mediated behaviors and the circuitry of BA information as it travels through the AOS. Importantly, my work opens many avenues for future studies. Here, I show evidence that five specific V1R receptors are BA-sensitive. The identification of ligands that can modulate the activity of orphan VRs is paramount to understanding their function and in turn understanding chemosensation. We now have more tools in the toolbox to understanding and studying the activation of VRs, their signal transduction, and their function
Evaluation of Social Stories in Sleep Treatment for Children with Autism Spectrum Disorder: A Feasibility Study
Get PDFA majority of children with autism spectrum disorders (ASD) experience sleep disturbances which are apt to negatively impact cognition, behavioral functioning, and the general trajectory of psychosocial development. Additionally, pediatric sleep disorders may contribute to disordered sleep in parents and reduced quality of life for family members. While children with ASD often respond positively to general standard of care in pediatric sleep medicine, there are few sleep treatments that address ASD-specific factors that contribute to sleep disturbances. This limitation may be addressed through the development of a treatment that incorporates sleep behavioral strategies in a format developed for children with ASD, such as a social story. This study evaluated the feasibility and acceptability of using a social story on bedtime routine developed for children as a complementary intervention for standard of care in a pediatric sleep clinic. Results from this study indicated social stories are acceptable as a complementary tool to sleep treatment. All participants approached for the study gave consent. Of those enrolled in the treatment group, all participants randomized to the treatment group read the story for at least one week as part of the bedtime routine (100%) with a mean utilization of 19.4 days during the month. Participants reported the social story was easy to implement and well received by the children, though feedback indicated the need for personalization and flexibility in the implementation of social stories. There were no significant differences in pediatric sleep outcomes between treatment groups. There were significant challenges related to the feasibility of the study in terms of gathering follow-up data, partially due to the impact of the COVID-19 worldwide pandemic that occurred during the study. Secondary analyses found no significant differences in parental sleep outcomes or psychosocial functioning between treatment groups. These findings suggest that social stories may be a promising tool in pediatric sleep treatment for children with ASD, but additional research is warranted to clarify its efficacy
Translating enzyme biologics into the clinic: an academic perspective
No full textDetailed formal protocol with illustrations and extensive bibliography.A recording of the protocol presentation is available on UT Southwestern's Mediasite. Note: Access to the video is restricted to authorized UT Southwestern users only.UT Southwestern--Internal Medicin
Ageism in rheumatology: the health care professional's perspective
No full textDetailed formal protocol with illustrations and extensive bibliography.A recording of the protocol presentation is available on UT Southwestern's Mediasite. Note: Access to the video is restricted to authorized UT Southwestern users only.This edition of the UT Southwestern Internal Medicine Grand Rounds features presentations by the six Foster Fellows selected as finalists from the Eighth Annual Donald W. Seldin, M.D. Research Symposium, which was held on April 28, 2023. These Foster Fellows presented work that spanned the breadth and depth of scholarly activity across the department, and at the close of Grand Rounds, one will be selected as the 2023 Seldin Scholar, in honor of Dr. Donald W. Seldin. The Grand Rounds presentation includes additional award presentations recognizing Clinical Vignettes, as well as the Award for Research in Quality of Care and Education at Parkland Hospital, the Social Impact Award, and the Award for Basic Science (non-GME).UT Southwestern--Internal MedicineAssociations of Cumulative Stress with Cardiovascular Risk Factors and Outcomes: Findings from the Dallas Heart Study / Ijeoma Eleazu --
Small Peptide, Large Implications: Endotrophin in HFpEF / Lisandro Maya Ramos --
Therapeutic Hypothermia in Low-Risk Non-Pumped Brain-Dead Kidney Donors / Juan Salcedo Betancourt --
Frailty Status Modifies the Efficacy of Primary Prevention ICD Therapy Among Patients with Heart Failure / Sumitabh Singh --
Ageism in Rheumatology: The Health Care Professional's Perspective / Aaron Smith
Definition of Anisocoria in Neurocritical Patients
Get PDFThis study deals with examination of anisocoria at rest and after light exposure using a set of various cutoff points.This poster was presented at the 9th Annual Neuro and Intensive Care: Review, Workshops and Controversies 2023 in Orlando, Florida, on May 12, 2023.INTRODUCTION: Anisocoria, defined as the absolute difference in left and right pupil diameter, is an important clinical finding. However, the definition of anisocoria varies and clinicians have limited reliability in estimating pupil size through subjective measurements. Using a quantitative pupillometer (QP) increases the accuracy and consistency in pupil measurement.
OBJECTIVES: The primary objective of this study is to examine the presence of anisocoria at rest, and anisocoria after exposure to light, using QP in a cohort of Neuroscience intensive care unit (NSICU) patients. The secondary objective is to explore anisocoria using different cutpoints for differences in size.
MATERIALS & METHODS: Retrospective analysis from an international registry was queried to obtain the first paired QP measurement from patients admitted to one of 4 US and 2 international NSICUs.
DISCUSSION/RESULTS: Sample size includes 5769 patients with a mean age of 57.5 (17.6%) years. Of these, 2,558 (51.5%) were female, 3,669 (75.5%) were White, and 4,369 (89.2%) were non-Hispanic. Hospital length of stay was a median of 6 (3 to 14) days, and the median ICU length of stay was (1 to 8) days. Using the smallest cutpoint of > 0.5 mm, anisocoria was present at rest in 1,642 (28.2%) and after light stimulus in 885 (15.3%) observations (P 2.0 mm anisocoria was present at rest in 79 (1.4%) of our sample and after light stimulus in 74 (1.3%) observations (P<.0001).
SUMMARY/CONCLUSION: There is a statistically significant difference in anisocoria before and after exposing the pupil to light. This difference persists across anisocoria cutpoints ranging from 0.5 to 2.0mm. Future study should examine anisocoria before and after light exposure for association with radiological or clinical findings