Bosnian Journal of Basic Medical Sciences (BJBMS)
Not a member yet
1863 research outputs found
Sort by
Cardiovascular Responses in the Treadmill Stress Exercise in Young Adults of Sarajevo in the Period of the War
Full text linkhis study was designed and performed under very difficult conditions during intensive war activities in Sarajevo. The specific characteristics of this aggressive war were a long lasting. Middle Ages siege of the city with sudden shelling and shooting of civilian targets. It can be expected that these abnormal, stressful conditions caused changes in mental and emotional reactions, as well as in the functioning of numerous organic systems. The aim of this study was to assess whether the long exposure to war conditions influenced the functioning of the cardiovascular system and its response in stress exercise in young adults of Sarajevo.
Multistage, incremental exercise treadmill testing under the Bruce protocol was performed by 14 male students of Sarajevo University (aged 18-23 years). It was planned for each subject to complete two exercise sessions in a three-month interval. Only 8 persons completed the second session because some of the subjects left Sarajevo, some were wounded, and the rest of them had to complete their duties in the Army.
The results of the two exercise sessions showed that resting values of the cardiovascular variables (heart rate, arterial blood pressure) were within physiological range. The mean maximal exercise capacity expressed as metabolic units (METS) was 15.40 for the first exercise session and 15.23 for the second one. There were neither significant differences in exercise test duration between the two exercise sessions nor in maximal achieved heart rate.
It could be concluded that in young men the overall exercise capacity was well preserved but the other results (indirectly calculated maximal oxygen uptake, V02) indicated hyperreactive response. The three-month interval was short to emphasize the differences because the war conditions, under which the testing was performed, were not changed
Research project: State and Stimulation of Development in Children Aged 8-9 Living Under War Conditions
Full text linkThe somatic, functional and metabolic characteristics of children at 8 years of age have been established. These children have, for the previous three years, lived under stressful conditions of direct shelling, poor nutrition and movement. At the same time there has been an evaluation of the effects of programmed physical activities which have been applied in the aim of stimulating natural physical dynamics and functional developments and the elimination of stagnation of development which occurs from conditions of unfavorable factors. The research and the program of physical activities included 41 boys, starting at an average age of 8 years and four months. The somatic characteristics of the boys, according to 25 antropo-metric measures (IBP), show a lag in the boy’s physical development according to their age group by one year. The lagging behind is especially evident in volume dimensions and underskin tissue fat (Przulj, 1991., Bonacin, 1995. Blaha, 1982.). An improvement of conditions and a greater scope of movement activities for the duration of 8 months did not significantly influence on the improvement of the somatic and functional status of the boys in comparison with the controlled group (N=21) of the same average age during another measurement period. While resting, on the level of aerobic threshold, anaerobic threshold and maximal oxygen uptake, the value of ergonometric, functional and metabolic parameters were confirmed: V02 stpd, Ve btps. Ve * V02-1, Ve*VC02-l, RQ, fc (beats*min-l), work load in Watts and on the basis of these relative indicators were completed. The gradual growth of work load was completed with the help of bicyklergometer (Monark). After 3 minutes of easy pedaling (warming-up) an initial work load was given of Watt*body mass and increased by 1/3 of the mass*Watt every minute until the achievement of maximal oxygen uptake. Individual aerobic and anaerobic thresholds (Aep) and (Anp), for each person examined were confirmed on the basis of the smallest sizes in the points of the crucial curves Ve*V02-l and Ve*VC02-l (Wasserman et al., 1973 and 1991, Cooper et al, 1984, Yacov, 1991). For the level of maximum oxygen uptake, the work load was taken, on which the greatest worth of V02 was achieved and it did not increase with the foflowing greater work load. The average value of ergono-metric, functional and metabolic parameters of the initial state and the final measurement of the experiment group:
-level of aerobic threshold: 2.4 and 2.3 work load (Watt*mass-1), 30.57 and 28.37 V02kg(ml*kg-1 *min-I), 168.6 and 166.6 fc(beats*min-l), 5.08 and 5.31 V02*fc-1, 64.7 ad 62.6 V02*V02 max-1 %, 85.9 and 85.4 fc*fc(V02max)-l %, 63.4 and 62.6 W*W(V02max-l)%,
-level of anaerobic threshold: 2.7 and 2.7 work load (Watt*mass-1), 33.15 and 34.54 V02 kg(ml*kg-l*min-1), 175.4 and 175.7 fc (beats*min-l), 5.6 and 6.1 V02*fc-I, 74.4 and 76.2 V02*V02max-l%, 89.3 and 90.1 fc*fc(V02max), 70.7 and 72.7 W*W(V02max)-1%,
-level of maximum oxygen uptake: 3.8 and 3.7 work load (Watt*mass-1), 47.2 and 45.3 V02kg(ml*kg-l*min-l), 196.3 and 195.1 fc(beats*min-l), 6.8 and 7.3 V02*fc-1.
Significant statistical differences are confirmed only on the values of V02* fc-1 I and II measuring Ρ = 001.
The results confirm the assumption of the general stråte-gy of adaptation, directed in the formation and protection of functional reserves from exhaustion, for priority of growth needs and development and only on that basis can an increase of ability for an even greater level of their total and rational usage can occur. For a significant growth ability of a greater level of mobilization of functional reserves there is a need for a greater intensity and a longer time period in completing physical activities
The Effects of Combined SarCNU and Ganglioside Treatment of Growth of C6 Glioma Cell Cultures
Full text linkIn vitro antiproliferative effects of SarCNU and GMI ganglioside were tested in different concentration ratios in C6 glioma cell culture. Based on MTT assay and a protein assay, cytotoxicity of each agent separately and the two agents combined was tested. When the cells were treated with different concentrations of ganglioside ranging from 10-’ to 10-2, the number of viable cells decreased highly on days two and seven, regardless of the concentration of the agent applied. SarCNU, as expected, has caused antiproliferative effects which highly correlated with the concentration of the agent tested. When the C6 glioma cell culture was treated with the two agents combined in the optimal concentration causing the above mentioned cytotoxicity, effects observed did not correlate with those observed for each agent alone, suggesting in this case the expression of highly neuroprotective effects of ganglioside GMI