DataCat: The Research Data Catalogue (University of Liverpool)
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Student and staff survey data on generative artificial intelligence use for academic purposes
Get PDFSurvey responses from staff and students at the University of Liverpool on how they use generative artificial intelligence for academic purposes
Recovery quality and arterial oxygen tension in horses
No full textArterial oxygen tension values from horses recovering from general anaesthesi
Soft electrochemical gating of charge transport across phenothiazine molecular wires
No full textThe dataset for the molecular junction of a specific phenothiazine molecule measured by STM-BJ and EC-STM technique. The cyclic voltammetry data of the phenothiazine molecule
KIDS: kinematics-based (in)activity detection and segmentation in a sleep case study
No full textSleep behaviour and in-bed movements contain rich information on the neurophysiological health of people, and have a direct link to the general well-being and quality of life. Standard clinical practices rely on polysomnography for sleep assessment; however, it is intrusive, performed in unfamiliar environments and requires trained personnel. Progress has been made on less invasive sensor technologies, such as actigraphy, but clinical validation raises concerns over their reliability and precision. Additionally, the field lacks a widely acceptable algorithm, with proposed approaches ranging from raw signal or feature thresholding to data-hungry classification models, many of which are unfamiliar to medical staff. This paper proposes an online Bayesian probabilistic framework for objective (in)activity detection and segmentation based on clinically meaningful joint kinematics, measured by a custom-made wearable sensor. Intuitive three-dimensional visualisations of kinematic timeseries were accomplished through dimension reduction based preprocessing, offering out-of-the-box framework explainability potentially useful for clinical monitoring and diagnosis. The proposed framework attained up to 99.2% F1-score and 0.96 Pearson's correlation coefficient in, respectively, the posture change detection and inactivity segmentation tasks. The work paves the way for a reliable home-based analysis of movements during sleep which would serve patient-centred longitudinal care plans
Data for: A selfish genetic element and its suppressor causes gross damage to testes in a fly
No full textSelfish genetic elements (SGEs), specifically X-chromosome meiotic drive (XCMD), create huge conflicts within a host’s genome and can have profound effects on fertility. Suppressors are a common evolutionary response to XCMD to negate its costs. However, whether suppressors themselves can cause negative non-target effects remains understudied. Here, we examine whether the intragenomic conflicts created by XCMD and its suppressor affects gonad morphology in Drosophila subobscura. We found significant differences in testes, seminal vesicle, and accessory gland size depending on whether a male carried a non-driving X chromosome, an XCMD, and if the XCMD was suppressed. We also found the first evidence of extreme whole-organ damage to testes that is specifically associated with a suppressor of XCMD. Unlike other studies, our evidence suggests that XCMD in D. subobscura inflicts extreme damage on male gonads. This damage is most severe if both XCMD and its suppressor are both present. While costs of suppression have importance in theoretical models, they have largely been ignored in empirical XCMD systems. Overall, this study highlights that genetic conflict, created by SGEs and their suppressors, is a potent evolutionary force that can have major impacts on gonad development and gametogenesis
Orthognathic Patient self-esteem scores and perceived attractiveness
No full textOrthognathic patients self-esteem scores, perceived attractiveness and perceived need for orthognathic surger
Non-typhoidal salmonella contamination along the pork value chain in a rural East African setting: a cross-sectional study
Get PDFBackground: Non-typhoidal Salmonella (NTS) is a serious foodborne pathogen which has previously been isolated from pigs presented for slaughter in a rural pork value chain in western Kenya.
Methods: To understand varying NTS contamination along the value chain we assessed prevalence at slaughter, transport & retail. Suspect isolates from culture were confirmed using MALDI-TOF Mass Spectrometry.
Results: Prevalence on pig carcasses, meat transportation containers, retailed raw & cooked pork and accompanying side-salads was 18.1%, 23.9%, 28.0%, 1.9% & 8.6% respectively.
Conclusion: NTS contamination is propagated along the pork value chain in rural western Kenya, demonstrating the need for improved hygiene measures to prevent human exposure
Cryo-electrospinning generates highly porous fiber scaffolds which improves trabecular meshwork cell infiltration
Get PDFCryogenic electrospinning increases pore size, porosity and thickness and polymeric scaffolds following incorporation of dry ice into the traditional electrospinning process. This in turn can generate highly porous biomimetic scaffolds of human tissue and encourage more in vivo-like cellular characteristics and overcome the poor cellular infiltration observed with traditional electrospun polymer scaffolds
The Collaborate project: Developing feasible person-centred care alternatives to emergency department responses for adults with epilepsy: a discrete choice analysis mixed methods study
No full textThis is a multicomponent project. The data set includes data from most of its components (namely, survey of service providers, Discrete Choice Experiments; and ‘Knowledge Exchange’ workshops). The remainder (interviews with service users) is archived by a subcontractor who has ownership of it. Any use of data files is subject to permission from the lead author and must be acknowledged. It should not be used within explicit written permission.
For context, the project abstract is as follows:
Background: Calls have been made for paramedics to have some form of care pathway that they could use to safely divert adults with epilepsy away from emergency departments and instigate ambulatory care improvements. Different configurations are possible. To know which to prioritise for implementation/evaluation, there is a need to determine which are acceptable to service users and likely NHS feasible.
Objective(s): 1) Identify configurations being considered; 2) understand service users’ views of them and current provision; 3) identify what sort of care service users want; and 4) determine which configuration/s is considered to achieve optimal balance in meeting users’ preference and being NHS feasible.
Design: Service providers were surveyed to address objective 1. Interviews with service users addressed objective 2. Objective 3 was addressed by completing Discrete Choice Experiments. These determined users’ care preferences for different seizure scenarios. Objective 4 was addressed by completing ‘Knowledge Exchange’ workshops. At these, stakeholders considered the findings on users’ stated preferences and judged different pathway configurations against Michie’s ‘APEASE’ feasibility criteria.
Setting: This project took place in England. The survey recruited representatives from neurology and neuroscience centres and from urgent and emergency care providers. For the interviews, recruitment occurred via third-sector support groups. Recruitment for the Discrete Choice Experiments occurred via the North-West ambulance service and public advert. Workshop participants were recruited from neurology and neuroscience centres, urgent and emergency care providers, support groups and commissioning networks.
Participants: Seventy-two services completed the survey. Interviews were conducted with 25 adults with epilepsy (and 5 relatives) who had emergency service contact in the prior 12 months. Discrete Choice Experiments were completed by 427 adults with epilepsy (and 167 relatives) who had ambulance service contact in the prior 12 months. Workshops were completed with 27 stakeholders.
Results: The survey identified a range of pathway configurations. They differed in where they would take the patient and their potential to instigate ambulatory care improvements. Users had been rarely consulted in designing them. The Discrete Choice Experiments found users want a configuration of care markedly different to that offered. Across the seizure scenarios, users wanted: their paramedic to have access to their medical records; for an epilepsy specialist (e.g., an epilepsy nurse, neurologist) to be available to advise; for their GP to receive a report; for the incident to generate an appointment with an epilepsy specialist; for the care episode to last less than 6-hours; and, there was a pattern of preference to avoid conveyance to emergency departments and stay where they were. Stakeholders judged this configuration to be NHS feasible within 5-10 years, with some elements being immediately deployable.
Limitations: The Discrete Choice Experiment sample was broadly representative, but those reporting recent contact with an epilepsy specialist were over-represented .
Conclusions: Users state they want a configuration of care that is markedly different to current provision. The configuration they prefer was, with support and investment, judged to likely be NHS feasible
In the Eye and Mind of the Beholder: The Effects of Familiarity on the Perception of Atypical Infant Facial Configurations.
No full textDataset to accompany In the Eye and Mind of the Beholder: The Effects of Familiarity on the Perception of Atypical Infant Facial Configurations. Contains eye tracking and subjective appraisal data for both typical and cleft-affected infants. Particpants were two groups of females: a group who were familiarised with cleft related stimuli prior to testing and a control group
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