University of Castilla-La Mancha
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[Dentro y fuera del cubo blanco] Las consecuencias del Guggenheim Bilbao como modelo turístico en el siglo XXI: Reflexiones en torno a la arquitectura de museos
Get PDFMonitoring the Subolesin Vaccine Field Trial for Safer Control of Cattle Ticks Amidst Increasing Acaricide Resistance in Uganda
Get PDFA collaboration program was established between the group of Health and Biotechnology
(SaBio) of the IREC Institute of Game and Wildlife Research (CSIC-UCLM-JCCM, Spain) and the
National Agricultural Research Organization of Uganda (NARO) for the development of vaccines
for the control of cattle ticks in Uganda. Controlled pen trials identified a tick protective antigen,
Rhipicephalus appendiculatus Subolesin, and a cross-species-effective vaccine formulation. As the next
step, a controlled vaccine field trial has been approved by Ugandan state regulatory authorities, the
Uganda National Council for Science and Technology (UNCST) and the National Drug Authority
(NDA), to evaluate the efficacy and effectiveness of the vaccine formulation for the control of cattle
tick infestations under field conditions. The results of this trial may lead to the approval of the
vaccine for application in Uganda to improve cattle health and production while reducing the use
of acaricides.Se estableció un programa de colaboración entre el grupo de Sanidad y Biotecnología
(SaBio) del Instituto de Investigación de la Caza y la Fauna Silvestre (CSIC-UCLM-JCCM, España) y la
Organización Nacional de Investigación Agrícola de Uganda (NARO) para el desarrollo de vacunas
para el control de las garrapatas del ganado en Uganda. Los ensayos controlados en corral identificaron un antígeno protector de las garrapatas,
Rhipicephalus appendiculatus Subolesin, y una formulación de vacuna eficaz para todas las especies.
Como siguiente paso, las autoridades reguladoras del estado ugandés, el Consejo Nacional de Ciencia y Tecnología de Uganda, han aprobado un ensayo controlado de campo de la vacuna.
Consejo Nacional de Ciencia y Tecnología de Uganda (UNCST) y la Autoridad Nacional de Medicamentos
(NDA), para evaluar la eficacia y efectividad de la formulación de la vacuna para el control de las infestaciones de garrapatas en el ganado.
infestaciones por garrapatas en condiciones de campo. Los resultados de este ensayo pueden conducir a la aprobación de la vacuna
de la vacuna para su aplicación en Uganda, con el fin de mejorar la salud y la producción del ganado y reducir el uso de acaricidas.
de acaricidas
Influencia de un programa de expresión corporal en la imagen corporal en niños y niñas de Educación Primaria
Get PDFEste estudio pretendió observar el efecto de un programa de expresión corporal en la imagen
corporal de alumnos de 12 años. El programa incluyó siete sesiones de 45 minutos de
dramatización y baile. Se obtuvieron mediciones pre y post con 33 alumnos (n = 13 grupo control
-GC-; n = 20 grupo experimental -GE-). Para conocer su imagen corporal se utilizó una escala de
figuras corporales (Children’s Ten Bodies Scale). Los resultados revelaron mayor satisfacción
corporal en el GE en comparación con el GC, aunque no hubo diferencias significativas tras la
intervención y tampoco se encontraron diferencias por género. Sin embargo, las chicas del GE
mostraron menos insatisfacción corporal en el post-test (M = -0,57) que en el pre-test (M = -
2,37). Los resultados sugieren que las actividades expresivas podrían ayudar a mejorar la imagen
corporal, especialmente en chicas
Impact of COVID-19 on long term care: the case of residential facilities. SESPAS Report 2022
Get PDFLas residencias de mayores han sido el foco de mayor impacto de la COVID-19 en materia de mortalidad y
de situaciones extremas, junto con los centros sanitarios. El principal objetivo de este artículo es describir
cómo afectó la llegada del SARS-CoV-2 a las residencias de mayores en Espa˜na durante los primeros meses
pandémicos, y apuntar lecciones aprendidas. Pese a las medidas y normativas aprobadas en las primeras
semanas de marzo de 2020, las residencias no estaban preparadas para la llegada de una epidemia como
la vivida. El indicador más claro de ello es un fuerte impacto sobre la mortalidad en las residencias. El
exceso de fallecimientos en las residencias se ha estimado en 26.448 personas entre marzo de 2020 y
mayo de 2021 (un 10,6% del total de las personas dependientes atendidas en residencias, con un exceso de
mortalidad del 43,5%), concentrándose las muertes en los primeros meses de la pandemia. Sin embargo,
hay otros efectos que cabe rese˜ nar, como los que afectan a la salud mental y la calidad de vida de residentes,
familiares y personal de las residencias. Asumiendo que posiblemente no hay dos pandemias iguales, es
imprescindible extraer de la experiencia vivida ense˜nanzas que puedan resultar de utilidad para estar
preparados ante situaciones futuras similares y reforzar un sistema de cuidados de larga duración que ya
era frágil antes de la llegada del SARS-CoV-2.Facilities have been the focus of the greatest impact of COVID-19 in terms of mortality and extreme
situations, along with health centers. The main objective of this article is to describe how the arrival
of SARS-CoV-2 affected facilities, focusing on Spain during the first pandemic months, and to point out
lessons learned. Despite the measures and regulations approved in the first weeks of March 2020, these
centers were not prepared for the arrival of an epidemic such as the one experienced. The clearest indicator
of this is a strong impact on mortality in residential facilities. The excess of deaths in residences
has been estimated at 26,448 people between March 2020 and May 2021 (10.6% of the total number
of dependents cared for in residences, with an excess mortality of 43.5%), with deaths concentrated in
the first months of the pandemic. However, there are other effects to be considered such as those that
affect the mental health and quality of life of residents, family members, and residential facilities staff.
Assuming that no two pandemics are possibly alike, it is essential to draw lessons from lived experience
that may be useful to prepare for similar future situations and strengthen a long-term care system that
was already frail before the arrival of SARS-CoV-2
Resolución de 24/05/2022, de la Universidad de Castilla-La Mancha, por la que se publica el Reglamento de evaluación del estudiante de la Universidad de Castilla-La Mancha
Get PDFGeometric transformation-based data augmentation on defect classification of segmented images of semiconductor materials using a ResNet50 convolutional neural network
No full textThe emergence of machine learning (ML) and deep learning (DL) techniques opens a huge opportunity for their implementation in industry. One of the tasks for which these techniques have the greatest potential is visual inspection, since both ML and DL techniques are able to determine relationships between large volumes of data. However, these techniques require large volumes of images that cannot always be captured. As a solution to this, data augmentation techniques are applied. In this work, starting from a highly imbalanced dataset containing images of different semiconductor defects, several datasets are generated using data augmentation techniques based on geometric transformations. A ResNet50 convolutional neural network is then fed with each of he datasets to analyze the effect of data augmentation on its classification performance. The results reveal that, with an adequate number of synthetic images of the minority classes, the F1-score improves by 3.74% over that obtained with the original dataset
Comparison of Nine Early Warning Scores for Identification of Short-Term Mortality in Acute Neurological Disease in Emergency Department
Get PDFBackground: The aim was screening the performance of nine Early Warning Scores (EWS), to identify patients at high-risk of premature impairment and to detect intensive care unit (ICU) admissions, as well as to track the 2-, 7-, 14-, and 28-day mortality in a cohort of patients diagnosed with an acute neurological condition.
Methods: We conducted a prospective, longitudinal, observational study, calculating the EWS [Modified Early Warning Score (MEWS), National Early Warning Score (NEWS), VitalPAC Early Warning Score (ViEWS), Modified Rapid Emergency Medicine Score (MREMS), Early Warning Score (EWS), Hamilton Early Warning Score (HEWS), Standardised Early Warning Score (SEWS), WHO Prognostic Scored System (WPSS), and Rapid Acute Physiology Score (RAPS)] upon the arrival of patients to the emergency department.
Results: In all, 1160 patients were included: 808 patients were hospitalized, 199 cases (17%) required ICU care, and 6% of patients died (64 cases) within 2 days, which rose to 16% (183 cases) within 28 days. The highest area under the curve for predicting the need for ICU admissions was obtained by RAPS and MEWS. For predicting mortality, MREMS obtained the best scores for 2- and 28-day mortality.
Conclusions: This is the first study to explore whether several EWS accurately identify the risk of ICU admissions and mortality, at different time points, in patients with acute neurological disorders. Every score analyzed obtained good results, but it is suggested that the use of RAPS, MEWS, and MREMS should be preferred in the acute setting, for patients with neurological impairment
Assessment of Genotoxicity Induced by Subchronic Exposure to Graphene in HaCaT Human Skin Cell Line
Get PDFThe applications of graphene-based materials (GBMs) and even their processing involve
prolonged contact with cellular barriers such as human skin. Even though the potential
cytotoxicity of graphene has been studied in recent years, the impact of long-term graphene
exposure has rarely been explored. We tested in the HaCaT epithelial cells, in vitro, the effect
of subchronic treatments with subletal doses of four different, well-characterized GBMs, two
commercial graphene oxides (GO) and two few-layer graphenes (FLG). Cells were exposed
weekly to low doses of the GBMs for 14 days, 30 days, 3 months, and 6 months. GBMs-cells
uptake was assessed by confocal microscopy. Cell death and cell cycle were determined by
fluorescence microscopy and cytometry, respectively. DNA damage was measured by comet
assay and g-H2AX staining, followed by determination of p-p53 and p-ATR by
immunolabeling. Subchronic exposure to different GBMs at non-cytotoxic doses has potential
genotoxic effects on HaCaT epithelial cells, that can be recovered depending on the GBM and
exposure time. Specifically, GO-induced genotoxicity can be detected after 14 and 30 days
from treatment. At this time, FLG appears less genotoxic than GO, and cells can recover more
easily when genotoxic pressure disappears after some days removal of the GBM. Long-term
exposure, 3 and 6 months, to different GBMs induces permanent, non-reversible, genotoxic
damage that is comparable than the exerted by arsenite. This should be considered for the
production and future applications of GBMs in scenarios where low concentrations of the
material interact chronically with epithelial barriers
Thickness gradient related magnetic anisotropy of wedged Co nanocluster assemblies deposited on glass plates
Get PDFWe prove the existence of uniaxial magnetic anisotropy (UMA) directly related to thickness gradients in a material system comprised of planar assemblies of Co nanoclusters (diameter 2.5 nm), grown by pulsed laser deposition (PLD) on bare glass substrates. PLD provides a widespread coating that takes place with a decreasing thickness along the radial directions of a glass plate faced perpendicular to the ablation jet, yielding a wedge like shape of the film thickness profile. Reflection and transmission magneto optical effects enabled us to study magnetization vector as a function of the film thickness and location, revealing in plane magnetization with a well defined UMA along the in plane direction parallel to the thickness gradient only in high gradient films. The dependence of anisotropy energy on film thickness has been analyzed within a phenomenological model, accounting for the surface and bulk contributions to the effective magnetic anisotropy energy (MAE). According to that, below a threshold thickness, the volume contribution is low and Neel like interface contribution to MAE is negligible, as well as the null magneto crystalline contributions of such a disorder cluster system, leaving only potential surface terms left. MAE is thus tentatively explained with the extra cluster terraces related to high gradient thickness. Additionally, the magnetization along the in plane hard axis or thickness gradient direction (TGD) includes a minor out of plane component noticed as a Faraday rotation in transmission geometry. We speculate it may arise from geometrical frustration of moments occurred in the hard axis magnetization of the network of interconnected assemblies
Orden de 115/2022, de 10 de junio, de la Consejería de Educación, Cultura y Deportes, de precios públicos que regirán en Castilla-La Mancha para los estudios conducentes a la obtención de títulos oficiales y servicios de naturaleza académica, prestados por las universidades públicas de su competencia y se da publicidad a las tasas vigentes durante el curso académico 2022/2023 (no vigente)
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