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IL-8 and LYPD8 expression levels are associated with the inflammatory response in the colon of patients with ulcerative colitis
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Splice variants of lysosome?associated membrane proteins 2A and 2B are involved in sunitinib resistance in human renal cell carcinoma cells
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Processing and Characterization of In-situ Synthesized and Hot-extruded Aluminum Matrix Composites Reinforced with Al2O3-TiB2-TiC Ceramic Particles
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Prevention of tumor progression in inflammation-related carcinogenesis by anti-inflammatory and anti-mutagenic effects brought about by ingesting fermented brown rice and rice bran with Aspergillus oryzae (FBRA)
Get PDFFermented brown rice and rice bran with Aspergillus oryzae (FBRA) has shown chemopreventive effectiveness against inflammation-related carcinogenesis, by inhibiting inflammation. We found that Aspergillus oryzae is the main component of the anti-inflammatory effect of FBRA and that the intestinal flora is involved. Mice fed FBRA were found to have a lower tumor-forming rate than mice fed the basic diet. Tumor cell lines obtained from basic diet-fed mice metastasized to distant organs. By contrast, those from FBRA-fed mice acquired reduced metastatic capacity. Micronucleus testing detected somatic mutations in tumor cell lines directly established from primary tumors; these decreased in a dose-dependent manner in FBRA-fed mice. To determine whether FBRA ingestion induced systemic anti-mutagenicity, micronucleus testing was performed using reticulocytes in mice injected with typical mutagens. Mutations induced by these mutagens were suppressed in FBRA-fed mice. These results indicate that anti-inflammation and anti-mutagenicity induced by FBRA intake suppressed the inflammation-related carcinogenic process
Atorvastatin preferentially inhibits the growth of high ZEB-expressing canine cancer cells
No full textThe epithelial-to-mesenchymal transition (EMT) is fundamental in cancer progression and contributes to the acquisition of malignant properties. The statin class of cholesterol-lowering drugs exhibits pleiotropic anticancer effects in vitro and in vivo, and many epidemiologic studies have reported a correlation between statin use and reduced cancer mortality. We have shown previously that sensitivity to the anti-proliferative effect of statins varies among human cancer cells and statins are more effective against mesenchymal-like cells than epithelial-like ones in human cancers. There have only been few reports on the application of statins to cancer therapy in veterinary medicine, and differences in statin sensitivity among canine cancer cells have not been examined. In this study, we aimed to clarify the correlation between sensitivity to atorvastatin and epithelial/mesenchymal states in 11 canine cancer cell lines derived from mammary gland, squamous cell carcinoma, lung, and melanoma. Sensitivity to atorvastatin varied among canine cancer cells, with IC50 values ranging from 5.92 to 71.5 μM at 48 h, which were higher than the plasma concentrations clinically achieved with statin therapy. Atorvastatin preferentially attenuated the proliferation of mesenchymal-like cells. In particular, highly statin-sensitive cells were characterized by aberrant expression of the ZEB family of EMT-inducing transcription factors. However, ZEB2 silencing in highly sensitive cells did not induce resistance to atorvastatin. Taken together, these results suggest that high expression of ZEB is a characteristic of highly statin-sensitive cells and could be a molecular marker for predicting whether cancers are sensitive to statins, though ZEB itself does not confer statin sensitivity
Flower color and anthocyanin biosynthesis genes analysis in Hirado azalea (Rhododendron x pulchrum Sweet)
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