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ハッタツ ショウガイジ ノ オヤ ニ タイスル タイメンシキ ト エンカクシキ ノ ペアレント トレーニング ノ コウカ ノ ヒカク
Full text link鳥取大学Tottori University博士（医学
Studies on the utilization of brackish-water areas and ecology of the San-in Subpopulation of Oryzias latipes in the Hii River system, Shimane Prefecture
Full text link鳥取大学Tottori University博士（農学
チュウサ シボウサン トウヨ ハ ベータ－ ヒドロキシ ラクサン レベル オ ゾウカ サセル コトデ ドウブツ モデル ニオイテ コウウツ コウカ オ ユウハツスル
Full text link鳥取大学Tottori University博士（医学
5-Aminolevulinic Acid-Mediated Metronomic Photodynamic Therapy for Mouse Mammary Tumors
No full textBackground : Metronomic photodynamic therapy (mPDT) is a novel cancer treatment strategy that uses low-dose light delivery and photosensitizers. 5-aminolevulinic acid (5-ALA), a precursor of protoporphyrin IX (PpIX) was previously used to treat human colorectal and esophageal cancer cells. However, no study has evaluated the efficacy of 5-ALA-mPDT using light of different wavelengths. Therefore, we evaluated cytotoxicity induced by 5-ALA-PDT and the antitumor effect of 5-ALA-mPDT. Methods : In an in vitro experiment, we evaluated the cytotoxicity induced by 5-ALA-PDT using several fluence rates of light-emitting diode (LED) at wavelengths of 532 and 620 nm. In an in vivo experiment, we evaluated the antitumor effect of 5-ALA-mPDT using a newly developed implantable device emitting 532 or 620 nm. Moreover, we used in silico simulations to compare the differences in the distribution of the accumulated singlet oxygen concentrations between 532 and 620 nm. Results : In the in vitro experiment, the percentages of late apoptotic/Dead and Dead cells in the 542-nm groups irradiated at light intensities of 1 mW/cm2 were significantly higher than those of cells in the 620-nm group. In contrast, in the in vivo experiment, the antitumor effect of mPDT using an implantable organic light-emitting diode (OLED) at 620 nm was significantly higher than that of mPDT using OLED at 542 nm. Conclusion : Considering the results of our in silico study, the antitumor effect of 5-ALA-mPDT may be dependent on the distribution range of the accumulated singlet oxygen concentration rather than the accumulated singlet oxygen concentration
Psychological Factors Related to Social Exclusion of Hikikomori (Prolonged Social Withdrawal) Individuals by Local Residents
No full textBackground : The number of hikikomori individuals has been increasing not only in Japan but also worldwide while few studies have looked into the societal elements that could lead to further isolation of hikikomori individuals. This study examines the psychological factors in local residents related to social exclusion of hikikomori individuals. Methods : 365 participants living in Tottori, Japan were analyzed. The questionnaire includes key questions such as social exclusion of hikikomori individuals, daily lifestyle, personal opinions and attitudes towards hikikomori individuals. Results : Those who are unwilling to interact with people who have different sense of values were 3.6 times likely to exclude hikikomori individuals than those who did not. Those who believe that hikikomori is a family issue so that others should not intervene were 2.2 times likely to exclude them than those who did not. Conversely, those who think that people can make a fresh start in the society even after making mistakes were 0.5 times likely to exclude hikikomori than those who did not. Those who feel that they have something in common with hikikomori individuals were 0.4 times likely to exclude them than those who did not. Those who think that they can enjoy activities such as hobbies together with hikikomori individuals were 0.3 times likely to exclude them than those who did not. Conclusion : The analysis indicates that the tendency to reject relationships with people who have different sense of values and the opinion that hikikomori is a family issue are the risk factors for social exclusion of hikikomori individuals. Contrarily, the opinion that even if we make a mistake or fail, we can make a fresh start, awareness of the similarities between oneself and hikikomori individuals, and willingness to share enjoyable activities with them are shown to be the protective factors which could reduce social exclusion of hikikomori
Rectal Resection with Hysterectomy for Locally Advanced Rectal Cancer Using the hinotori Surgical Robot System : The First Ever Case Report
No full textThe number of reports of robotic surgery for rectal cancer with combined resection of other organs is increasing gradually, with most procedures performed using the da Vinci Surgical System. The hinotori Surgical Robot System, developed in Japan, was approved for gastrointestinal surgery and gynecology in 2022. Here, we report the first case of en-bloc rectal resection with hysterectomy using the hinotori Surgical Robot System. A 77-year-old woman was referred to our institution with a diagnosis of rectal cancer (cT4bN1bM1a), with uterine invasion and a resectable liver metastasis. We performed rectal resection with total hysterectomy and bilateral salpingo-oophorectomy using the hinotori Surgical Robot System. Two surgical teams, a gastroenterological team and a gynecological team, performed en-bloc resection of the rectum and uterus. Because of in-depth consultation between the teams, the operation was performed safely with no unplanned additional ports, robotic arm interference or arm collision with the assistant surgeon. Including the preceding stoma closure, the operative time was 473 minutes, and blood loss was 60 mL. The patient experienced no complications ≥ Clavien–Dindo classification grade III. Robot-assisted extended surgery for locally advanced rectal cancer using the hinotori Surgical Robot System can be performed safely, which may lead to an expanded treatment option in the future
Two Cases of Papillary Renal Neoplasm with Reverse Polarity : Radiologic–Pathologic Correlation
No full textPapillary renal neoplasm with reverse polarity (PRNRP) is a distinct subtype of papillary renal tumors first described in 2019. Here, we present the imaging and histopathological findings of two cases of PRNRP. Case 1 involved a 71-year-old man with an incidental right renal mass. A 30 mm tumor in the right kidney exhibited isoto slight hyperattenuation on non-contrast computed tomography (CT). Dynamic contrast-enhanced (DCE)-CT revealed a tumor with solid and cystic components. The solid portion showed mild enhancement, followed by gradual enhancement. Regarding magnetic resonance imaging (MRI), the cystic component revealed mild hyperintensity on T2-weighted imaging (WI) and hyperintensity on T1WI. The small, lobulated solid component showed hyperintensity on T2WI and no apparent hyperintensity on diffusion-weighted imaging, with high ADC values. Case 2 involved a 74-year-old woman with a gradually enlarging left renal mass. A 20 mm tumor in the left kidney showed heterogeneous mild hyperattenuation on non-contrast CT. On DCE-CT, a small solid component exhibited mild enhancement, followed by gradual enhancement. Retrospectively, the mass showed an 8 mm homogeneous nodule on CT images obtained 7 years earlier. Although the tumor appears heterogeneous on CT, a small PRNRP may exhibit homogeneous attenuation. Additionally, the solid portion can show T2 hyperintensity related to stromal edema. Recognition of these imaging variations is important for the correct diagnosis of PRNRP