9510 research outputs found
Sort by
Whole-genome sequence of Geobacillus thermodenitrificans K1041, a genetically tractable strain representative of the genus Geobacillus
Get PDFWe present the whole-genome sequence of Geobacillus thermodenitrificans K1041, a bacterium that was originally identified as a genetically tractable thermophile. The genome consists of a circular chromosome that contains 3,848 genes. The sequence has a total size of 3,755,826 bp with a GC content of 49.18%
Auxiliary Loss for BERT-Based Paragraph Segmentation
Get PDFParagraph segmentation is a text segmentation task. Iikura et al. achieved excellent results on paragraph segmentation by introducing focal loss to Bidirectional Encoder Representations from Transformers. In this study, we investigated paragraph segmentation on Daily News and Novel datasets. Based on the approach proposed by Iikura et al., we used auxiliary loss to train the model to improve paragraph segmentation performance. Consequently, the average F1-score obtained by the approach of Iikura et al. was 0.6704 on the Daily News dataset, whereas that of our approach was 0.6801. Our approach thus improved the performance by approximately 1%. The performance improvement was also confirmed on the Novel dataset. Furthermore, the results of two-tailed paired t-tests indicated that there was a statistical significance between the performance of the two approaches
HMG-CoA reductase degrader, SR-12813, counteracts statin-induced upregulation of HMG-CoA reductase and augments the anticancer effect of atorvastatin
Get PDFStatins are cholesterol-lowering drugs that have exhibited potential as cancer therapeutic agents. However, as some cancer cells are resistant to statins, broadening an anticancer spectrum of statins is desirable. The upregulated expression of the statin target enzyme, 3-hydroxy-3-methyl-glutaryl-coenzyme A (HMG-CoA) reductase (HMGCR), in statin-treated cancer cells is a well-known mechanism of statin resistance, which can be counteracted by the downregulation of HMGCR gene expression, or degradation of the HMGCR protein. However, the mechanism by which HMGCR degradation influences the anticancer effects of statins remain unreported. We tested the effect of the HMGCR degrader compound SR-12813 at a concentration that did not affect the growth of eight diverse tumor cell lines. Combined treatment with atorvastatin and a low concentration of SR-12813 led to lowering of increased HMGCR expression, and augmented the cytostatic effect of atorvastatin in both statin-resistant and -sensitive cancer cells compared with that of atorvastatin treatment alone. Dual-targeting of HMGCR using statins and SR-12813 (or similar compounds) could provide an improved anticancer therapeutic approach
Electrochemical Conversion of Glucosamine Monosaccharides into Variety of Linear and Cyclic Oligosaccharides
Get PDF鳥取大学博士(工学
Physiological and Biochemical Characterization of Root Cell Wall in Suaeda salsa and Spinach oleracea under Saline Condition
Get PDF鳥取大学博士(農学
