Repositorio institucional - Concytec
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Pvmsp8 as a novel plasmodium vivax malaria sero-marker for the peruvian amazon
No full textThe measurement of recent malaria exposure can support malaria control efforts. This study evaluated serological responses to an in-house Plasmodium vivax Merozoite Surface Protein 8 (PvMSP8) expressed in a Baculovirus system as sero-marker of recent exposure to P. vivax (Pv) in the Peruvian Amazon. In a first evaluation, IgGs against PvMSP8 and PvMSP10 proteins were measured by Luminex in a cohort of 422 Amazonian individuals with known history of Pv exposure (monthly data of infection status by qPCR and/or microscopy over five months). Both serological responses were able to discriminate between exposed and non-exposed individuals in a good manner, with slightly higher performance of anti-PvMSP10 IgGs (area under the curve AUC = 0.78 [95% CI = 0.72–0.83]) than anti-PvMSP8 IgGs (AUC = 0.72 [95% CI = 0.67–0.78]) (p = 0.01). In a second evaluation, the analysis by ELISA of 1251 plasma samples, collected during a population-based cross-sectional survey, confirmed the good performance of anti-PvMSP8 IgGs for discriminating between individuals with Pv infection at the time of survey and/or with antecedent of Pv in the past month (AUC = 0.79 [95% CI = 0.74–0.83]). Anti-PvMSP8 IgG antibodies can be considered as a good biomarker of recent Pv exposure in low-moderate transmission settings of the Peruvian Amazon. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.Consejo Nacional de Ciencia, Tecnología e Innovación Tecnológica - Concyte
On almost automorphic type solutions of abstract integral equations, a Bohr-Neugebauer type property and some applications
No full textIn the present work we give some sufficient conditions to obtain a unique almost automorphic solution to abstract nonlinear integral equations which are simultaneously of advanced and delayed type and also a unique asymptotically almost automorphic mild solution to abstract integro-differential equations with nonlocal initial conditions, both situations are posed on Banach spaces. Also, we develop a Bohr-Neugebauer type result for the abstract integral equations. Before that, we introduce the notion of ?-bounded functions, develop the appropriate abstract theory and discuss the almost periodic situation. As applications, we study the existence of an asymptotically almost automorphic solution to integro-differential equations modeling heat conduction in materials with memory and also the existence of the almost automorphic solution to semilinear parabolic evolution equations with finite delay. © 2020 Elsevier Inc.Consejo Nacional de Ciencia, Tecnología e Innovación Tecnológica - Concyte
Analysis and determination of solar potential using models based on climatic parameters for the district of San Mateo, province of Huarochiri, Lima Peru
No full textIt shows the analysis and determination of solar potential throght models based on climatic parameters for the district of San Mateo, Province of Huarochiri, located in Lima, PeruConsejo Nacional de Ciencia, Tecnología e Innovación Tecnológica - Concyte
Microbial characterization of a natural biofilm associated with peruvian scallop (Argopecten purpuratus) larvae settlement on artificial collector by confocal imaging, microbiology, and metagenomic analysis
No full textBiofilms strongly influence bivalve settlement patterns on artificial substrates; however, their structure and taxonomic composition remains a black box. We characterized a natural biofilm composition that exhibits a large settlement of larvae of the Peruvian scallop Argopecten purpuratus by culture-dependent and culture-independent methods. Thirty-two different strains, representing six genera (10 strains of Bacillus, 9 of Vibrio, 6 Acinetobacter, 4 Staphylococcus, 2 Photobacterium, and 1 Exiguobacterium) were isolated. Those strains represented only 1.09% of the relative abundance compared with the total microbiota obtained by 16S rRNA high-throughput sequencing. The metagenomic analysis identified 441 species. Prokaryotes were predominant (93.4%) over eukaryotes (6.6%), with Pelobacter (13.4%), Lewinella (5.6%), Marinobacter (5.4%), Hoeflea (4.2%), and Microcystis (3.1%) being the most representative genera. Laser scanning confocal microscopy (LSCM) imaging evidenced an irregular and heterogeneous biofilm with an average thickness of 35 µm, where the heterotrophic prokaryotic community (3.4×106 cell cm-2) dominate the photoautotrophic communities (2.3×105 cell cm-2). For the first time, an A. purpuratus settlement-related biofilm was described by the next generation sequencing tool (NGS) and compared with traditional methodologies.Consejo Nacional de Ciencia, Tecnología e Innovación Tecnológica - Concyte
The Effect of Alkali Treatment on Chemical and Physical Properties of Ichu and Cabuya Fibers
No full textIchu and Cabuya were characterized and the effect of alkali treatment on the chemical and physical properties of these fibers was studied. This treatment was carried out to remove non-cellulosic components in order to improve the adhesion of these fibers to be used as reinforcing composites since they are currently being tested in polymer matrix composites. The chemical properties were investigated through TAPPI Standards and FTIR spectroscopy. The physical properties (microfibrillar angle and density) were analyzed through polarized light microscopy and a gas pycnometer, respectively. The results show that with this chemical treatment, it is possible to remove 53.9% of lignin and 22.7% of hemicellulose for Ichu fiber and 50.7% and 91.7%, respectively, for Cabuya. Besides, it was found that the microfibrillar angle is not affected by this chemical treatment since its effect is only superficial. In addition, SEM images show that Ichu fiber has amorphous silica particles in its surface, in which it becomes a potential fiber for cement composites. © 2019 Taylor & Francis.Consejo Nacional de Ciencia, Tecnología e Innovación Tecnológica - Concyte
Is exclusive breastfeeding for six-months protective against pediatric tuberculosis?
No full textExperts recommend exclusive breastfeeding from birth to six months because it protects against deadly childhood illness, including respiratory tract infections and diarrhea. We hypothesized that exclusive breastfeeding would decrease the risk of active tuberculosis (TB) in children. We analyzed cross-sectional data from 279 children in Lima, Peru aged 6 to 59 months with TB symptoms and a close adult contact with TB. Mothers self-reported breastfeeding, and children were evaluated for TB per national guidelines. To quantify the association between exclusive breastfeeding and TB, we estimated prevalence ratios using a generalized linear model with a log link, binomial distribution, and robust variance. Twenty-two percent of children were diagnosed with TB and 72% were exclusively breastfed for six months. We found no evidence that six months of exclusive breastfeeding was associated with TB disease in either bivariate analyses (prevalence ratio [PR] = 1.5; 95%CI = 0.8–2.5) or multivariable analyses adjusting for sex and socioeconomic status (adjusted PR = 1.6; 95%[CI] = 0.9–2.7). In post hoc analyses among children whose close TB contact was their mother, we found evidence of a weak positive association between breastfeeding and TB (aPR = 2.1; 95%[CI] = 0.9–4.9). This association was not apparent among children whose close contact was not the mother (aPR = 1.2; 95%[CI] = 0.6–2.4). Our results raise the possibility that children who are breastfed by mothers with TB may be at increased risk for TB, given the close contact. Due to the cross-sectional study design, these results should be interpreted with caution. If these findings are confirmed in longitudinal analyses, future interventions could aim to minimize TB transmission from mothers with TB to breastfeeding infants. © 2020 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.Fondo Nacional de Desarrollo Científico y Tecnológico - Fondecy
Informe sobre las causas del elevado número de muertes por la pandemia del COVID-19 en el Perú
No full textMenciona que el Perú tiene la mayor cantidad de muertes por COVID-19 por millón de habitantes del mundo; dicha constatación nos plantea la urgente necesidad de buscar las causas más relevantes de esta tragedia. El presente informe es el resultado de dicha indagación. Ha sido elaborado por un Comité multidisciplinario y plural convocado y apoyado por el Consejo Nacional de Ciencia, Tecnología e Innovación(CONCYTEC)
Datos abiertos para la investigación
Full text linkPresenta la estrategia nacional de inteligencia artificial, el avance del uso de datos abiertos en algunos países y brinda pautas acerca de la estrategia nacional de gobierno de datos
Estándares y metadatos en repositorios: buenas prácticas
Full text linkAborda recomendaciones sobre estándares y metadatos que los gestores de los repositorios digitales deben considerar para una mejor interoperabilidad y calidad de sus plataformas
Bursera graveolens essential oil: Physiochemical characterization and antimicrobial activity in pathogenic microorganisms found in Kajikia audax
No full textThe authors thank to Universidad Nacional de Tumbes, Universidad Nacional de Ingenieria and Fondo Nacional de Desarrollo Cientifico, Tecnologico y de Innovacion Tecnologica (Contrato No 02-2018-FONDECYT-BM-IADT-MU).Essential oils are products from aromatic plants, which, due to their biological, allelopathic, antioxidant and antimicrobial effects, are important for food preservation. Kajikia audax is a fish of great commercial importance, however, it is highly perishable, requiring strategies to extend its shelf life. In vitro antimicrobial activity of Bursera graveolens essential oil was determined against microorganisms isolated from K. audax. Essential oil was extracted by steam distillation, obtaining a yield of 1.25%, a density of 0.83 g/ml and a refractive index of 1.473°, in addition, it was determined by GC-MS that D-limonene (77.6%) is the majority compound. Antimicrobial tests showed that the minimum inhibitory concentration (MIC) for Aeromonas salmonicida and Pichia kudriavzevii was 1.62 mg/ml and 6.48 mg/ml respectively, and the minimum bactericidal concentration (MBC) was 25.92 mg/ml for both microorganisms. Pseudomonas aeruginosa showed total resistance against the concentrations used. B. graveolens essential oil turned out to be a potential product to control the growth of microorganisms isolated from K. audax, however, it should be tested against species of the genera Vibrio, Flavobacterium, Shewanella, Lactococcus and Streptococcus that cause spoiling of hydrobiological products.Consejo Nacional de Ciencia, Tecnología e Innovación Tecnológica - Concyte