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An experimental study on hybrid fibre reinforced engineered cementitious composite link slabs under static and fatigue loadings
No full textThis study conducted experimental investigations on the structural performances of link slabs which are constructed by using a newly developed hybrid-fibre reinforced engineered cementitious composite (hybrid-ECC). Both static and fatigue loadings were applied to validate the feasibility, provide a proof of concept study and demonstrate the benefits using hybrid-ECC for bridge link slabs application. Three identical quarter-scaled hybrid-ECC link slabs, simulating a link slab used for a typical 35-meter multi-span simply supported bridge, were fabricated. These slabs, denoted as LS-1, LS-2 and LS-3, were tested under designated static and fatigue loadings. Slab LS-1 was tested under static loading to obtain the flexural strength of the slab. Slabs LS-2 and LS-3 were tested under fatigue loadings to evaluate their fatigue performances under normal service loading and overload scenarios, respectively. Structural performances of these slabs in terms of deformation and crack width control capability, strain development on reinforcement bars and estimated service life were evaluated. It was observed that multiple microcracks were developed under both static and fatigue loadings. Slab LS-2 survived ten million cycles of service fatigue loading while LS-3 survived two million cycles of overload fatigue loading. For all the tests conducted under static and fatigue loadings, the maximum crack width observed on the three link slab samples was all controlled within the allowable limit of 0.2 mm until failure occurred. Based on the test results, it was estimated that if only the effects due to normal traffic loading and temperature variation were considered, the hybrid-ECC link slab could achieve a service life of more than 40 years. Therefore, the experimental study reconfirmed that the hybrid-ECC showed a high potential to improve the fatigue performance and extend the service life of link slab in bridge construction
Memorialisation, reconciliation and truth-speaking : the role of explorer and massacre memorials in settler-colonial Australia
No full textMemorialisation in settler-colonial nations such as Australia is intensely political. It creates public symbols of people and events those in authority consider important and worthy of remembrance. Counter-narratives of various marginalised others are silenced through processes of collective forgetting. In Australia, this forgetting has meant that colonial histories of exploration and discovery have been commemorated through ubiquitous explorer memorials. But these memorials represent a very selective account of settler-colonial history firmly based in the colonial fiction of terra nullius or empty land used to justify the British claim to Australia. This fiction is now being actively countered by social protests focused on memorials to explorers and colonial administrators. Furthermore, a trend to memorialise and commemorate the massacres of Aboriginal and Torres Strait Islander peoples as part of the colonisation process is overturning the myth that Australia was peacefully settled. In fact, truth-speaking is now recognised by Aboriginal and non-Aboriginal Australians as an integral part of the reconciliation process. However, the truths spoken as part of the shared memorialisation of Aboriginal massacre sites by the Australian reconciliation movement are only partial, and may serve to perpetuate rather than interrupt what has historically been a resounding silence about colonial dispossession and violence
Digital twin-based automated green building assessment framework
No full textAccurate green building assessment (GBA) represents one of the best opportunities to understand the holistic sustainability strengths and weaknesses of existing buildings to inform their retrofitting decisions. However, the current process for GBA of existing buildings is very challenging, tedious, complex, time-consuming and costly, and suffers from lack of important data and information. Moreover, most GBA results are not leveraged to retrofit and improve the sustainability performance of existing buildings – they are mostly for just recognition and market edge. To address these limitations, this study aims to develop a framework for using Digital Twin (DT) technology to automate and improve GBA. Although unavailable static building data can be obtained from scan-to-building information modelling (BIM) process, real-time dynamic data cannot. Hence, real-time dynamic data from the internet of things (IoT) sensors and other data should be integrated into the BIM model to create the DT model of the building. A plug-in software can then be deployed to assess the sustainability performance level of the building within the DT environment automatically. The framework is based on the Building Environmental Assessment Method (BEAM) Plus, which is Hong Kong’s leading GBA system. A real DT should feedback into the physical twin after receiving and processing data from it. Therefore, the automated GBA results should inform retrofitting decisions of the physical building. This study contributes to the understanding of how DT can be used to automate and improve GBA, and how the results can be used to improve retrofitting decision-making
A survey of Indonesian nurses' educational experiences and self-perceived capability to care for people with intellectual disability and/or autism spectrum disorder
No full textAims: To describe Indonesian nurses' educational experience regarding care for people with intellectual disability and/or autism and to explore if these educational experiences are associated with their self-perceived confidence, comfort, knowledge and preparedness to care for these cohorts. Design: Cross-sectional descriptive survey. Methods: A descriptive survey tool utilized in a study of Australian registered nurses was replicated and adapted for this study. Following descriptive analysis, chi-square analyses were undertaken to explore associations between educational experiences, and self-rated measures of confidence, comfort and knowledge to work with people with intellectual disability and/or autism. Although there was no end-user involvement in the design of the study, the concepts explored have all been raised by those with lived insights of intellectual disability and/or autism as being critical to their healthcare experiences. Results: There were 544 complete responses, and 51.7% were not exposed to any educational or clinical content relevant to caring for people with intellectual disability and/or autism. Moderate to low levels of self-perceived confidence, comfort, knowledge and preparedness to address healthcare needs of these cohorts were reported. Significant associations were identified between educational and clinical experiences during undergraduate training, and higher levels of self-perceived confidence, comfort and knowledge. Conclusion: Mirroring international literature, the findings of this study highlight a large proportion of Indonesian nurses had little educational experience relevant to caring for people with intellectual disability and/or autism, and have relatively low levels of self-reported capability. Impact: This study highlights gaps in the educational experiences, and self-perceived confidence, comfort, knowledge and preparedness of Indonesian nurses regarding caring for people with intellectual disability and/or autism. Given that internationally, people with intellectual disability and/or autism have disproportionately negative health outcomes and experiences, these findings have substantial implications for nursing curriculum, policy and professional development
Wrapping things up : making plastic into a political material
No full textHow can we understand the role of plastic in generating diverse political impacts and situations? The introduction of plastic packaging into food markets in post-WWII Australia is used to pursue this question. This empirical foray is informed by debates about political materials and the interactions between technical devices and the administration of life. Making plastic packaging into a mundane market device involved establishing the responsibilities of the package: what it was obliged to do across various networks from food production to self-service. This history also shows how plastic packaging changed the ontological status of food. It provided a new point of articulation between the natural and the synthetic in relation to governing food that also had the effect of conditioning the government of humans, of suggesting to consumers that food wrapped in plastic was better across numerous registers. What the case of mundane plastic packaging shows is that the political impacts of materials aren’t essential or inevitable; they emerge in the process of enacting the capacities of materials in particular situations. Impacts do not exist independently of relations or the ways in which a material is made to matter
"Queer people are excellent caregivers, but we're stretched so very thin" : psychosocial wellbeing and impacts of caregiving among LGBTQI cancer carers
No full textBackground LGBTQI (lesbian, gay, bisexual, transgender, queer and/or intersex) communities are increasingly recognized as a vulnerable and high-risk population in oncology. LGBTQI cancer carers, including carers who are LGBTQI and other carers of LGBTQI people, experience many of the same stressors as LGBTQI patients but their support needs are often overlooked in the cancer literature. Method This mixed-methods study examined distress and quality of life in LGBTQI cancer carers. Online surveys were completed by 129 carers and 31 carers took part in a one-to-one semi-structured interview. Analyses of variance (ANOVAs) tested for diferences in psychosocial outcomes and carer experiences by gender, sexuality, age, carer relationship and carer/patient LGBTQI status. Refexive thematic analysis of interviews and open-ended survey responses facilitated in-depth examination of subjective experiences. Results 42.6% of participants reported high or very high distress. Distress was signifcantly positively correlated with discrimination in cancer care, health impact, fnancial impact and lack of family support; it was negatively correlated with comfort in LGBTQI sexuality and gender identity, social support and quality of life. Four themes were identifed in thematic analysis of qualitative data: (1) Identity on the sidelines: LGBTQI sexuality and gender pushed aside during cancer caregiving; (2) Fear of being shut-out: rejection and exclusion of LGBTQI cancer carers; (3) Lack of support for LGBTQI caregivers; and (4) Closer and stronger relationships due to a culture of mutual caregiving. Conclusions LGBTQI cancer carers must contend with typical caregiving demands whilst also managing additional minority stressors, including discrimination, rejection from family, isolation from LGBTQI communities, and invisibility in healthcare and support services. Despite this, LGBTQI carers showed resilience in building their own mutually supportive networks to rally around the person with cancer, which were reported to ameliorate psychosocial vulnerabilities. Service providers need to recognize the needs of LGBTQI cancer carers through inclusive and refective practices. This will facilitate trust and patient and carer sexuality and gender identity disclosure, with positive consequences for wellbeing and satisfaction with cancer care
Neonatal adiposity is associated with microRNAs in adipocyte-derived extracellular vesicles in maternal and cord blood, a discovery analysis
No full textBackground: Maternal body size, nutrition, and hyperglycemia contribute to neonatal body size and composition. There is little information on maternal-fetal transmission of messages which influence fetal growth. We analyzed adipocyte-derived small extracellular vesicular (ADsEV) microRNAs in maternal and cord blood to explore their adipogenic potential. Methods: There were 279 mother-neonate pairs with all phenotypic data (normal glucose tolerant NGT = 148, gestational diabetes mellitus GDM = 131). Neonates with adiposity were those in the highest tertile (T3) of sex-specific sum of skinfolds and those without adiposity (lean) in the lowest tertile T1 of NGT pregnancies. We studied ADsEV miRNAs in 76 and 51 neonates with and without adiposity respectively and their mothers based on power calculations (68 NGT and 59 GDM pregnancies). ADsEV miRNAs from maternal and cord blood plasma samples were profiled on Agilent 8*60 K microarray. Differential expression (DE) of ADsEV miRNAs in adipose vs. lean groups was studied before and after adjustment for maternal GDM, adiposity, and vitamin B12-folate status. Results: Multiple miRNAs were common in maternal and cord blood and positively correlated. We identified 24 maternal and 5 cord blood miRNAs differentially expressed (discovery p ≤ 0.1) in the adipose group in unadjusted, and 19 and 26, respectively, in the adjusted analyses. Even though DE miRNAs were different in maternal and cord blood, they targeted similar adipogenic pathways (e.g., the forkhead box O (FOXO) family of transcription factors, mitogen‑activated protein kinase (MAPK) pathway, transforming growth factor beta (TGF-β) pathway). Maternal GDM and adiposity were associated with many DE ADsEV miRNAs. Conclusion: Our results suggest that the ADsEV miRNAs in mothers are potential regulators of fetal adiposity. The expression and functionality of miRNAs appear to be influenced by maternal adiposity, hyperglycemia, and micronutrient status during pregnancy
Long-term warming increased carbon sequestration capacity in a humid subtropical forest
No full textTropical and subtropical forests play a crucial role in global carbon (C) pools, and their responses to warming can significantly impact C-climate feedback and predictions of future global warming. Despite earth system models projecting reductions in land C storage with warming, the magnitude of this response varies greatly between models, particularly in tropical and subtropical regions. Here, we conducted a field ecosystem-level warming experiment in a subtropical forest in southern China, by translocating mesocosms (ecosystem composed of soils and plants) across 600 m elevation gradients with temperature gradients of 2.1°C (moderate warming), to explore the response of ecosystem C dynamics of the subtropical forest to continuous 6-year warming. Compared with the control, the ecosystem C stock decreased by 3.8% under the first year of 2.1°C warming; but increased by 13.4% by the sixth year of 2.1°C warming. The increased ecosystem C stock by the sixth year of warming was mainly attributed to a combination of sustained increased plant C stock due to the maintenance of a high plant growth rate and unchanged soil C stock. The unchanged soil C stock was driven by compensating and offsetting thermal adaptation of soil microorganisms (unresponsive soil respiration and enzyme activity, and more stable microbial community), increased plant C input, and inhibitory C loss (decreased C leaching and inhibited temperature sensitivity of soil respiration) from soil drying. These results suggest that the humid subtropical forest C pool would not necessarily diminish consistently under future long-term warming. We highlight that differential and asynchronous responses of plant and soil C processes over relatively long-term periods should be considered when predicting the effects of climate warming on ecosystem C dynamics of subtropical forests
[In Press] Outcomes and associated clinical features of people with eating disorders participating in residential treatment facilities : a scoping review
No full textResidential treatment programs for eating disorders (EDs) have gained popularity in recent years, expanding beyond the United States to countries such as Canada, Italy, and the United Kingdom. These programs offer a “home-like” environment where individuals reside for several weeks or months, emphasising both physical restoration and psychological recovery. This scoping review aimed to provide an update since the most recent reviews on the literature regarding outcomes of residential treatment programs for EDs and to explore clinical features that were associated with these outcomes. Methods used followed the Joanna Briggs Institute guidelines for scoping reviews. A systematic search of electronic databases was conducted, and 12 studies met the inclusion criteria. All studies reported improvements in various outcomes from admission to discharge, including changes in eating psychopathology, weight restoration, depression, anxiety, and quality of life. Additionally, three studies reported positive outcomes at intervals after discharge and three predictive factors (self-compassion, personality organisation, and resistance to emotional vulnerability) were reported in a small number of studies. While residential treatment facilities consistently showed positive outcomes, the review highlights the need for randomised controlled studies to establish the efficacy of these programs for EDs. Future research should include controlled studies comparing residential facilities to other treatment settings and incorporate long-term follow-up outcomes and further studies of emergent predictive factors identified in this review
Gastroprotective potential of red onion (Allium cepa L.) peel in ethanol-induced gastric injury in rats : involvement of Nrf2/HO-1 and HMGB-1/NF-κB trajectories
No full textEthnopharmacological relevance: The utilization of plants with therapeutic properties in traditional medicine has a longstanding practice. Among them, the well-known Allium cepa L. commonly known as onion has been valued for its anti-inflammatory and antioxidant potential in the treatment of various ailments, including gastric ulcers. Aim of the study: This study investigated the gastroprotective potential of red onion peel extract and its fractions in a rat model of ethanol-induced gastric ulcer. Moreover, their phytochemical profiles were compared to identify the active metabolites. Materials and methods: Mass spectrometry-based metabolomics and chemometrics were performed for phytochemical analysis. Ethanol-induced gastric ulcer model was used to assess the gastroprotective activity. Nine groups of rats were allocated as follows: Group 1 was the normal control; Group 2 rats were used as a positive control/model and received 1 mL of absolute ethanol; and Group 3 rats were treated with famotidine at a dose of 20 mg/kg orally. Group 4 and 5 rats were treated with total acidified ethanolic extract (T1, T2). Group 6 and 7 rats were treated with anthocyanins-rich fractions (P1, P2). Groups 8 and 9 were the flavonoids-rich fraction (S1, S2) treatment. Prior to scarification, the ulcer index in mm was obtained from gastric tissues photographed beside a ruler with further analysis using ImageJ software. Results: Seventy key major and discriminatory metabolites were identified including flavonoids, anthocyanins, phenolic acids, and miscellaneous compounds. The examined extract and its fractions significantly reduced the ulcer index and inflammatory cytokines via downregulating HMGB-1/NF-κB. Also, they augmented the expression of Nrf2/HO-1 and reduced NOX1/4 mRNA expression. Moreover, there was a significant reduction in the oxidative stress and apoptotic biomarkers as well as a noticeable enhancement in histopathological changes of the stomach tissues. Conclusion: Red onion peels have a promising dose dependent gastroprotective potential in alcohol-induced ulcers via modulating Nrf2/HO-1 and HMGB-1/NF-κB trajectories. This highlights the potential of red onion peels in treating gastric ulcers