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Replication Data for Ferritin nanoconjugates guide trastuzumab brain delivery to promote an antitumor response in murine HER2 + breast cancer brain metastasis
No full textThis dataset contains raw data of the paper " Ferritin nanoconjugates guide trastuzumab brain delivery to promote an antitumor response in murine HER2+ breast cancer brain metastasis" by Sevieri M. et al.
Brain metastasis (BM) represents a clinical challenge for patients with advanced HER2 + breast cancer (BC). The monoclonal anti-HER2 antibody trastuzumab (TZ) improves survival of BC patients, but it has low central nervous system penetrance, being ineffective in treating BM. Previous studies showed that ferritin nanoparticles (HFn) may cross the blood brain barrier (BBB) through binding to the transferrin receptor 1 (TfR1). However, whether this has efficacy in promoting the trans-BBB delivery of TZ and combating BC BM was not studied yet. Here, we investigated the potential of HFn to drive TZ brain delivery and promote a targeted antitumor response in a murine model of BC BM established by stereotaxic injection of engineered BC cells overexpressing human HER2. HFn were covalently conjugated with TZ to obtain a nanoconjugate endowed with HER2 and TfR1 targeting specificity (H-TZ). H-TZ efficiently achieved TZ brain delivery upon intraperitoneal injection and triggered stable targeting of cancer cells. Treatment with H-TZ plus docetaxel significantly reduced tumor growth and shaped a protective brain microenvironment by engaging macrophage activation toward cancer cells. H-TZ-based treatment also avoided TZ-associated cardiotoxicity by preventing drug accumulation in the heart and did not induce any other major side effects when combined with docetaxel. These results provided in vivo demonstration of the pharmacological potential of H-TZ, able to tackle BC BM in combination with docetaxel. Indeed, upon systemic administration, the nanoconjugate guides TZ brain accumulation, reduces BM growth and limits side effects in off-target organs, thus showing promise for the management of HER2 + BC metastatic to the brain
Replication Data for bodipy for "The Role of Txnip in Mediating Low-Magnesium-Driven Endothelial Dysfunction"
No full textReplication Data for: bodip
Replication Data for "A Bayesian Causal Model to Support Decisions on Treating of a Vineyard"
No full textData from Monte Simulations to estimate incidenc
Replication data for "DOMINO: A Dataset for Context-Aware Human Activity Recognition using Mobile Devices"
No full textDOMINO is a public dataset for context-aware HAR that includes 25 users (wearing a smartphone and a smartwatch) performing 14 activities. During data acquisition, the mobile devices recorded both inertial and high-level context data while our team monitored the quality of the self-reported annotations
Check list Parco colline Lupi et al.
No full textA study finalised to create a first check list of the insects settled in different areas of a park called “Parco delle Colline” in Brescia Province (Northern Italy) ranging from 190 to 960 meters above sea level. It included the part of the park localized in the municipality of Brescia, and in two of the other four municipalities in the park. This area is a Local Park of Supra-municipal Interest (P.L.I.S.), which is a form of protection established by the Lombardy Region that allows municipalities to identify and safeguard areas of environmental and naturalistic significance. The check list study was executed with different methodologies from 2010 to 2013. A total of 409 species have been detected throughout the monitoring period. Considering the methods, pitfall traps covered the 75.9% of captures, followed by light traps (10.9%), visual sampling (5.8%) and the others (7.4%
Replication Data for: Absolute and benchmarked economic voting. A subnational perspective on a decade of elections in Southern Europe
No full textThe article analyses the 15 elections that took place between 2010 and 2019 in four South European countries – Greece, Italy, Portugal and Spain – through the lenses of the retrospective vote theory. The large within-country variation of economic conditions justifies the adoption of an original subnational perspective, while the explicit test of alternative economic quantities and horizons provides a more credible assessment of voters’ behaviours. Besides offering a taxonomy of local retrospective voting, the research found that citizens assessed the incumbents against regional unemployment levels and national growth dynamics, further benchmarking the local economic conditions against their past performances. These results give credit to the idea that the South European electorate shares similar references in assessing the economic competences of incumbent governments
Replication Data for DCF for "The Role of Txnip in Mediating Low-Magnesium-Driven Endothelial Dysfunction"
No full textReplication Data for: DCF siRNA TXNI
Replication data for "co-immunoprecipitation experiments" of "Cytoskeleton Protein Filamin A Is Required for Efficient Somatostatin Receptor Type 2 Internalization and Recycling through Rab5 and Rab4 Sorting Endosomes in Tumor Somatotroph Cells"
No full textRepresentative Immunofluorescence experiments and co-immunoprecipitation experiments performed in GH3 cells and GHoma cells showing FLNA and β-Arrestin2 Recruitment to cell surface activated SST2