Archivio Istituzionale della Ricerca- Università degli Studi di Foggia
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L’ANARCHICA, IL RIVOLUZIONARIO E L’AMORE. L’ASCESA DEL DUCE ATTRAVERSO LE LETTERE A LEDA RAFANELLI (1913-1914)
No full textWhat can real-world data teach us about treating patients with unresectable hepatocellular carcinoma?
No full textIntroduction: Hepatocellular carcinoma (HCC) remains a major global health concern, as it is the most common primary liver cancer and the fourth leading cause of cancer-related mortality. Areas covered: Immune checkpoint inhibitors (ICIs) have significantly shifted the treatment paradigm, offering promising survival outcomes. However, the controlled conditions of randomized clinical trials (RCTs) often fail to reflect real-world complexities, emphasizing the necessity for strong real-world evidence (RWE). RWE, in most cases derived from observational studies, provides critical insights into the effectiveness, safety, and tolerability of systemic therapies across diverse populations and settings. The authors searched MEDLINE, Ovid Embase, and Scopus for full-text published articles in any language from the inception to 30 June 2024. This review evaluates RWE on systemic therapies for advanced HCC, including tyrosine kinase inhibitors (TKIs) like sorafenib and lenvatinib, ICIs such as nivolumab and pembrolizumab, and combination therapies like atezolizumab/bevacizumab and durvalumab/tremelimumab. Expert opinion: Studies reveal discrepancies in treatment efficacy and adverse event profiles between RCTs and routine clinical practice, underscoring the need for individualized treatment strategies. RWE highlights the influence of liver disease etiology, liver function, and tumor burden on treatment outcomes, guiding therapy selection
Intelligenza artificiale e medicina narrativa: un paradigma pedagogico per un'educazione inclusiva e trasformativa.
No full textIl saggio analizza l’integrazione tra Intelligenza Artificia-le e Medicina Narrativa come un paradigma innovativo pedagogico ed educativo. Si esplorano e si analizzano le narrazioni dei pazienti e dei pro-fessionisti sanitari, per favorire un’educazione trasformativa e innovativa, per le professioni sanitarie, attraverso contesti formali ed informali, in un processo di lifelong education e di lifewide learning. La AI si configura come uno strumento critico ed un mezzo per potenziare pratiche didattiche in-clusive, sviluppare competenze relazionali e riflessive, promuovere abilità e capacità di ciascun soggetto, riscoprendo un approccio human centere
Correction: Peri‐intubation complications in critically ill obese patients: a secondary analysis of the international INTUBE cohort
No full textFollowing the publication of the original article [1], the author reported that due to an error the institutional author group was not indicated on the title page and therefore the institutional authors were not visible as being part of the INTUBE Study Investigators. The institutional author names given in the additional file 1 of the original article [1] have been added to the INTUBE Study Investigators institutional author group. The title page and the institutional author group has been updated in this correction article and the original article [1] has been corrected
Il raggiungimento del risultato quale possibile paradigma della legittimità dell'azione amministrativa. Osservazioni generali
No full textEscape room in 3D virtual worlds: Reflections on new digital skills for innovative teaching by special educational teachers in training.
No full textThe introduction of virtual worlds and digital escape rooms in education marks a significantmilestone for inclusive education. This study explored the impact of 3D Learning Virtual Worlds and escape roomson the motivation and digital skills of 840 special education teachers in training at the University of Foggia. Usingthe DigiComp 2.2 framework and the FrameVR.io platform, participants created immersive virtual worlds anddesigned educational escape rooms during their internships. Results showed significant improvements in digitalskills, particularly in problem-solving and digital content creation. Moreover, the System Usability Scale (SUS)analysis highlighted a positive perception of the usability of virtual worlds, with room for improvement. The studyconfirms the potential of virtual worlds in promoting active and inclusive learning, offering new opportunities forthe digital transformation of education
PLACE: Multicenter Study for Right Ventricular Failure on Mechanical Cardiocirculatory Supports
No full text: Isolated acute right ventricular failure (aRVF) is associated with poor prognosis in different scenarios. In severe conditions, temporary mechanical cardiocirculatory support (tMCS) is required. PLACE is an international, retrospective, multicenter registry including 17 centers that investigated patients affected by isolated aRVF and treated with various types of tMCS from January 2000 to December 2020. The registry included 644 (69.6% males, mean age: 55 years) patients. The most frequent etiologies were post-left ventricular assist device implantation (LVAD) and postcardiotomy shock. These patients received mostly mechanical circulatory support (MCS) and veno-arterial extracorporeal membrane oxygenation. Mean tMCS duration was 9 days, weaning was achieved in 70.5% of the patients, and the major cause of death on support was multiorgan failure (50.5%). The mortality rate was 45 and 48.4% in-hospital and at 3 month follow-up, respectively. Multivariable logistic regression analysis identified age, aRVF due to acute pulmonary hypertension, bilirubin level, and oliguria or anuria at tMCS implantation as risk factors for in-hospital mortality. Conversely, aRVF after LVAD was found to be associated with a lower risk of early mortality. In-hospital and 3 months mortality occurred in less than half of the aRVF-supported subjects. Furthermore, several preimplant aspects such as age, organ function, and type of tMCS are independently associated with in-hospital and 3 month mortality
