Archivio Istituzionale della Ricerca- Università degli Studi di Foggia
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Quanti nuovi nati potrebbero essere protetti da RSV sostituendo Palivizumab con Nirsevimab? Una cost savings analysis nella provincia di Foggia, stagione 2023-2024
No full textLetter and Word Processing in Developmental Dyslexia: Evidence from a Two-Alternative Forced Choice Task
No full textExploratory Study of the Effects of Digital Storytelling Using Tangible User Interfaces on Acquired Knowledge About a Story in a Group of Primary School Children
No full textLa deriva giurisprudenziale sull’ambito di applicazione del reato di indebita compensazione
No full textLa pronuncia in commento conferma quel filone giurisprudenziale che, in spregio ai
principi che hanno ispirato il sistema penale tributario introdotto dal D.Lgs. n.
74/2000, da un lato, inquadra l’ambito di applicazione del reato di indebita
compensazione, di cui all’art. 10-quater D.Lgs. n. 74/2000, attribuendo
inopinatamente rilevanza, ai fini della realizzazione della condotta, anche ai debiti
diversi da quelli per imposte dirette ed IVA, e, dall’altro, tende a parametrare la
soglia di punibilità sia ai debiti che ai crediti di qualsiasi natura portati in
compensazione, purché indicati nell’art. 17 D.Lgs. n. 241/1997
Madri oltre la pancia. Brevi riflessioni storiche sulla maternità sociale
No full textIl contributo approfondisce il tema del rapporto tra maternità biologica e maternità sociale attraverso le riflessioni di Ellen Key e dei suoi rapporti con Ersilia Bronzini Majno e Sibilla Aleramo nell'ottica del superamento del biologismo conservator
La responsabilità delle piattaforme digitali nella protezione dei minori tra normative e sfide etiche
No full textI casi di studio di Mary Wollstonecraft in The Wrongs of Woman
No full textAbstract: The Wrongs of Woman di Mary Wollstonecraft indaga cause ed effetti delle ingiustizie sociali perpetrate sulle donne. Wollstonecraft mette in relazione le prevaricazioni subite dalle donne appartenenti a diverse classi sociali con le strutture sociali, politiche ed economiche. L’ampia campionatura dei ‘wrongs of women’ sottolinea come la condizione femminile di sofferenza e sottomissione è imputabile a una società e a uno Stato che esigono riforme profonde e radicali
Sexual function recovery following open and robotic radical prostatectomy: results of an academic penile rehabilitation program
No full textDespite surgical advancements, erectile dysfunction (ED) is a common consequence of radical prostatectomy (RP). This study aimed to evaluate the impact of early penile rehabilitation within a dedicated penile rehabilitation program on assisted and unassisted erectile function (EF) recovery. All patients who underwent RP and at least 1 year follow-up at penile rehabilitation program in the Department of Urology, OORR Policlinico Riuniti (Foggia, Italy) were included. Treatment involved phosphodiesterase type 5 inhibitors (PDE5Is; tadalafil 20 mg, 1 tablet every other day), intracavernous injections (Caverject 5 μg, 1 vial per week), and daily use of vacuum erection devices (VEDs). Primary end point was EF recovery defined as International Index of Erectile Function-5 (IIEF-5) ≥21 with or without rehabilitation aids. IIEF-5 and prescribed treatments were prospectively collected at 3 months, 6 months, 9 months, 12 months, and 24 months. Among 570 eligible patients, 397 (69.6%) underwent rehabilitation. Patients who undergoing andro-rehabilitation were younger (65 months v s 70 months; P < 0.0001), had lower prostate-specific antigen (PSA) levels (5.9 ng ml -1vs 6.2 ng ml -1 ; P = 0.04), and lower grade tumors ( P = 0.001) compared to the patients who did not undergo sexual rehabilitation after radical prostatectomy. Two-year EF recovery rates in patients undergoing andro-rehabilitation ranged from 75% (preoperative IIEF-5 >16) to 45% (preoperative IIEF-5 <16) with rehabilitation aids. Combination treatments (PDE5I+VEDs with or without intracavernous injections) showed the highest rates of EF recovery (up to 80% at 2 years). EF recovery without rehabilitation aids was significantly higher for patients with IIEF-5 >21 (IIEF-5 >21 [36%] vs IIEF-5 of 17-21 [18%]; P = 0.01). Subanalysis indicated a moderate benefit of rehabilitation in patients with preoperative IIEF-5 <16 who underwent bilateral nerve-sparing RP. Participation in intensive penile rehabilitation programs improves EF recovery in patients undergoing RP. Preserving the neurovascular bundles may be beneficial for patients with preoperative ED
Application of an updated methodology to estimate the burden of healthcare-associated infections in Italy, 2022
No full textBackground: Accurate burden estimates are necessary to inform priority setting and rational resource allocation. Weighting prevalence inversely proportional to time-at-risk has been proposed as a solution for length-biased sampling, an important limitation affecting prevalence to incidence conversion for healthcare-associated infections (HAIs). Aim: This study aimed to update Italian burden estimates by calculating HAI incidence, attributable mortality and disability-adjusted life years (DALYs). Further, we describe an adapted methodology for burden estimations. Methods: We used data from the latest European Centre for Disease Prevention and Control (ECDC) point prevalence survey (PPS) of HAIs, conducted in Italy in November 2022, to calculate the burden of five major HAIs at national level. We adapted the Burden of Communicable Diseases in Europe (BCoDE) methodology to include inverse probability weighting and compared results of naïve and weighted calculations. Results: The national sample included 18,397 patients. Overall, 564.8 DALYs per 100,000 general population resulted from weighted calculations (95% uncertainty interval (UI): 450.04–694.38), with an annual incidence of 685.42 cases per 100,000 general population (95% UI: 611.09–760.86) and 33.23 deaths per 100,000 general population per year (95% UI: 28.62–38.33). Concerning naïve estimates, overall 1,017.81 DALYs per 100,000 general population were calculated (95% UI: 855.16–1,190.59). In both calculations, healthcare-acquired bloodstream infections had the highest burden in terms of DALYs per 100,000 hospitalised and general population. Conclusion: Our study confirmed the substantial burden of HAIs in Italy and renews the need to prioritise resources for infection prevention and control interventions
Validation of a Combined Prognostic Score Using Plasma Tumor DNA and Clinical Features in Metastatic Castration-Resistant Prostate Cancer Patients Treated with Taxanes
No full textPurpose: There is an urgent need of biomarkers to personalize metastatic castration-resistant prostate cancer (mCRPC) treatment. A new prognostic model described by our group combines molecular characteristics (ptDNA levels), metabolic features from PET-scans (metabolic tumor volume), clinical parameters (visceral metastases), and lab tests (lactate-dehydrogenase levels) in abiraterone or enzalutamide-treated patients. This study aims to validate the score on mCRPC patients undergoing taxane treatment. Patients and methods: Twenty-eight patients affected by mCRPC, pre-treated with abiraterone or enzalutamide, candidate for taxane-based treatments, have been prospectively evaluated. All patients underwent a basal PET/CT scan with F-choline and blood samples. The prognostic model previously described was applied to this population; based on the partial results of the parameters, we assigned the patients into three risk groups. Results: In the 28 patients evaluated, we observed a different median OS among the three risk groups (risk group I, 18.1 months [95% CI: 15.2-33.1 months]; risk group II, 12.7 months [4.9-18.6 months]; and risk group III, 10.1 months [3.4-15.4 months]; p = 0.012). Statistically significant differences were also observed for PFS. Conclusion: The prognostic score has confirmed to be a good prognostic tool also in a more advanced cohort of patients treated with taxanes. This tool may represent a valid method to refine prognostication and treatment selection in a cohort of patients where biomarkers are scarce