Archivio Istituzionale della Ricerca- Università degli Studi di Foggia
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WebTVs as Channels for Scientific Communication: A Case Study from the University of Foggia
No full textIn the digital age, universities, as centers of research and innovation, are embracing new modes of communication by integrating digital tools to disseminate educational content, engage diverse audiences, and enhance learning experiences. University Web TV stands as a prime example of this evolution, serving as a versatile multimedia platform for delivering academic lectures, seminars, and other educational resources to a global audience. By breaking down geographic barriers, it democratizes access to knowledge. Moreover, it enables universities to showcase their research initiatives, cultural events, and community outreach programs. This article aims to delve deeper into the significance of university Web TV and analyze its potential as a tool for research, data collection, and scientific dissemination. Finally, adopting a multidisciplinary approach, this paper will scrutinize the successful case of University Web TV at the University of Foggia (“WeUnifg” project). As an innovative and multifaceted tool, university Web TV has the potential to become the university channel of the future. Its myriad uses, from facilitating access to education to innovating teaching methods and promoting student involvement in academic research activities (and vice versa), are yet to be fully explored. Moreover, it holds significance in shaping public perception of science and attracting new talent to research
Enhanced prognostic value of four-tier hybrid grading system in Ta non-muscle-invasive bladder cancer
No full textObjectives: To compare the predictive performance of the World Health Organization (WHO) 1973, WHO 2004/2022, the three-tier (low grade [LG]/Grade 1 [G1]-G2, high grade [HG]/G2, and HG/G3), and four-tier (LG/G1, LG/G2, HG/G2, and HG/G3) hybrid grading systems in Ta non-muscle-invasive bladder cancer (NMIBC), by evaluating recurrence-free survival (RFS) and progression-free survival (PFS).
Patients and methods: This retrospective multicentre study included 1233 patients with pTa NMIBC treated with transurethral resection of bladder tumour, eventually followed by intravesical instillations as determined by their physicians, between 2010 and 2023, across 18 Italian hospitals. Pathologists graded resected tissues using the WHO 1973, WHO 2004/2022 classifications, and hybrid three-tier (LG, HG/G2, HG/G3) and four-tier (LG/G1, LG/G2, HG/G2, HG/G3) systems. Kaplan-Meier curves estimated RFS and PFS. Discriminative performance was assessed using Harrell's concordance index (C-index).
Results: Among 1233 patients with pTa NMIBC, 890 were classified as LG and 343 as HG according to the WHO 2004/2022 grading system, while 586, 405, and 242 were categorised as G1, G2, and G3, respectively, under the WHO 1973 system. With a median (interquartile range) follow-up of 26 (14-48) months, 418 patients experienced recurrence, including 184 with HG recurrence and 42 who progressed to MIBC. The C-index values for RFS were 0.60, 0.56, 0.57, and 0.61 for the WHO 1973, WHO 2004/2022, hybrid three-tier, and four-tier grading systems, respectively. For progression, the C-index values were 0.80, 0.74, 0.75, and 0.81 across the same systems, underscoring the superior predictive capacity of the four-tier classification. Nonetheless, the low number of MIBC progression events limits the robustness of these analyses.
Conclusion: Our findings highlight the superior prognostic accuracy of the four-tier hybrid classification in predicting recurrence and progression in patients with stage Ta NMIBC. By combining strengths from the WHO 1973 and 2004/2022, this hybrid model shows promise as tool for enhancing NMIBC patient management in clinical practice
Performance Evaluation of an Edge-Blockchain Architecture for Smart City
No full textThis paper presents a simulation-based methodology to evaluate the performance of a privacy-compliant edge-blockchain architecture for smart city environments. The proposed model combines edge computing with a private, permissioned blockchain to ensure low-latency processing, secure data management, and verifiable transactions. Using a discrete-event simulation framework, we analyze the behavior of the system under realistic workloads and time-varying traffic conditions. The model captures edge operations, including preprocessing and cryptographic tasks, as well as blockchain validation using Proof of Stake consensus. Several experiments explore saturation thresholds, resource utilization, and latency dynamics, under both synthetic and realistic traffic profiles. Results reveal how architectural bottlenecks shift depending on resource allocation and input rate, and demonstrate the importance of balanced dimensioning between edge and blockchain layers
"Il Simbolo nelle chiese dell’Occidente latino. Ricezione e traduzione del Simbolo di Nicea e di Costantinopoli"
No full text
Fe y humanismo en los Dialogi de Olimpia Morata
No full textEn el Renacimiento, algunas jóvenes eruditas brillan como iconos luminosos en el panorama cultural, dejando profundas huellas, ya sea por la fama de su sabiduría o por los elogios que recibieron de los intelectuales y escritores de la época. Casos así son bien conocidos y provienen, en su mayoría, de las cortes de las señorías italianas durante la primera mitad del siglo XVI. Sin
embargo, un factor exógeno transforma profundamente el
panorama cultural de la época, que durante décadas había girado en torno a “las damas y los caballeros, las armas y los amores” de la tradición ariostesca: la renovatio de la fe, la brusca irrupción de una nueva corriente proveniente de Alemania con la rebelión de un docto monje agustino y de Francia con la Institución de la religión cristiana de Jean Calvin.
Algunas mujeres abrazan la fe reformada (también en sus
variantes) y descubren la falacia del conocimiento secular que
habían cultivado hasta entonces. El caso más emblemático es, sin duda, el de Olimpia Morata, quien se convirtió en un mito dentro de la cultura protestante, especialmente gracias a Jules Bonnet, que le dedicó numerosos escritos en la segunda mitad del siglo XIX. El ensayo tiene como objetivo examinar los diálogos presentes en las Opera de Olimpia, en los que se destaca claramente la transición de una cultura clásica, considerada estéril y engañosa, al estudio de la Biblia con el fin de extraer enseñanzas provechosas para la vida espiritual
La trilogia di Pierre Lemaitre
No full textIl contributo riflette sulla portata storica e gli effetti divulgativi della trilogia del noto romanziere francese, dedicata alle due guerre mondiali e al periodo tra di esse. Si analizza la rispondenza dei tre romanzi picareschi alla realtà storica, e le finalità di un'opera che ha costituito un caso di successo letterario in Francia e in altri paesi
Real-World Outcomes and Molecular Profiling for Patients with Metastatic Castration-resistant Prostate Cancer with Lung Metastases: A Long-term Multicenter Experience
No full textBackground and objective: The prognostic impact of lung metastases (LuMs) in metastatic castration-resistant prostate cancer (mCRPC) remains poorly defined. Our aim was to evaluate the clinical and molecular characteristics of patients with mCRPC with LuMs and their outcomes. Methods: This retrospective multicenter study included 930 patients with mCRPC across 13 centers in Italy. The primary endpoint was the impact of LuMs on overall survival (OS), progression-free survival (PFS), and prostate-specific antigen (PSA) response. As a secondary endpoint, next-generation sequencing for a subgroup with LuMs was used to identify molecular characteristics that might be useful in guiding personalized therapy. Key findings and limitations: Among mCRPC patients treated with an androgen receptor signaling inhibitor, we observed no significant differences in median OS or PFS and PSA response between the LuMs group and the group with bone ± lymph node metastases. Multivariable analyses revealed that only Eastern Cooperative Oncology Group performance status, PSA level, prior docetaxel treatment, and number of metastatic lesions were significant independent factors for both OS and PFS. Comparison of the groups with LuMs only versus liver metastases revealed a significant association between LuMs and a longer OS (15 vs 10 mo; p = 0.002) and PFS (9 vs 5 mo; p = 0.002). The proportion of patients with a ≥50% PSA decline was higher in the LuMs group (odds ratio 3.57, 95% confidence interval 1.37-9.45; p = 0.004). Molecular profile results showed that TP53 mutations accounted for a lower proportion of the pathogenic variants in LuMs than in liver metastases (15% vs 89%). Limitations include the retrospective design and clinical heterogeneity of the population, in addition to unavailability of metastatic biopsies for more in-depth analyses. Conclusions and clinical implications: Our findings suggest that patients with LuMs in mCRPC exhibit clinical and molecular features more similar to those with bone ± lymph nodal metastases than to patients with liver metastases. Further prospective studies are warranted
