Archivio Istituzionale della Ricerca- Università degli Studi di Foggia
Not a member yet
55976 research outputs found
Sort by
Artificial Intelligence in Special Education: Enhancing IEP Design with CONALI & ChatGPT
No full text
Comparative analysis of Glyoxalase I gene expression in modern and ancient durum wheat (Triticum durum Desf.) genotypes under water stress at both vegetative and reproductive growth stages
No full textPerformance e sostenibilità economica dei servizi sanitari in provincia di Foggia e a livello regionale
No full textLa sostenibilità economica del Servizio Sanitario Nazionale è una sfida cruciale per garantire il diritto universale alla salute, soprattutto in un contesto di risorse pubbliche limitate. Questo volume, basato su un'analisi dettagliata dei dati di bilancio dell'ASL di Foggia, esplora le dinamiche dei costi e dell'efficienza gestionale nei principali ambiti dell'assistenza sanitaria: prevenzione collettiva, assistenza distrettuale e ospedaliera. Attraverso indicatori economici e finanziar, il testo offre una visione chiara delle criticità e delle opportunità per migliorare l'efficacia del sistema sanitario locale. Un contributo fondamentale per comprendere il bilanciamento tra qualità dell'offerta e sostenibilità economica, con implicazioni che travalicano i confini territoriali della Capitanat
C‐reactive protein to albumin ratio predicts early mortality in hospitalized older patients, independent of the admission diagnosis
No full textAbstract: Background: Malnutrition and systemic inflammation are prevalent among
older hospitalized patients and are associated with increased morbidity and mortality. The
C-reactive protein to albumin (CRP/Alb) ratio reflects inflammatory and nutritional status
and may serve as a useful prognostic biomarker. Objective: To evaluate the prognostic
value of the CRP/Alb ratio in predicting early in-hospital mortality in a large cohort of
elderly patients, independent of the admission diagnosis. Methods: This retrospective observational study examined the clinical data and serum values of serum C-reactive protein
(CRP), albumin, and the CRP/Alb ratio, detected at the time of admission, in a cohort of
2780 patients over sixty-five admitted to the Internal Medicine and Aging Department of
the “Policlinico Riuniti” University Hospital Trust in Foggia, between 2019 and 2024. The
predictive power of the CRP/Alb ratio for 7- and 30-day hospital mortality was evaluated
by ROC curve analysis, Cox regression, and Kaplan–Meier survival analysis. Results:
In total, 444 patients died (16%) during their in-hospital stay. The CRP/Alb ratio was
significantly higher among deceased subjects (p < 0.001) than in non-deceased patients. The
CRP/Alb ratio was strongly associated with mortality, particularly during the first 7 days
from admission (AUC = 0.888). A CRP/Alb ratio >8 was an independent and significant
predictor of mortality within 30 days (HR = 3.82, 95% CI: 2.91–5.01), but particularly within
the first 7 days from hospitalization (HR = 10.17, 95% CI: 6.05–17.08). Similar results were
observed among re-hospitalized patients. Conclusions: The CRP/Alb ratio is a significant
and independent predictor of early in-hospital mortality in elderly patients, regardless of
admission diagnosis. A threshold value >8 identifies individuals at high risk, particularly
within the first week of hospitalization. This simple, cost-effective biomarker may support
early risk stratification and guide targeted interventions in geriatric care
Fratture del tempo, forme del potere: Reinhart Koselleck e la semantica della modernità
No full textThis article offers a theoretical contextualization of the volume Crisi, sovranità, Europa, dedicated to the centenary of Reinhart Koselleck’s birth. It revisits some central categories of Koselleck’s thought—crisis, sovereignty, and Europe—highlighting their genealogical complexity and their continued relevance in the analysis of contemporary political structures. Far from being static notions, these concepts are presented as dynamic and historically contingent, shaped by ruptures, institutional transformations, and evolving semantics. Drawing on Koselleck’s conceptual history (Begriffsgeschichte), the article reconstructs the critical potential of his approach in confronting the tensions and discontinuities of modern European political experience. Particular attention is paid to the temporal semantics of crisis, the transformation of sovereignty in the post-national age, and the symbolic construction of Europe through language, institutions, and collective expectations
Sex and gender differences during the lung lifespan: unveiling a pivotal impact
No full textSex and gender differences significantly influence lung parenchyma development, beginning as early as the embryonic stages of human life. Although this association is well known in the clinical manifestations of some relevant pulmonary diseases, there is less data available regarding their effects on cell biological programmes across different stages of body development. A deep understanding of these mechanisms could help in defining preventive strategies tailored to a fully personalised approach to respiratory medicine. From this perspective, this review aims to analyse the influence of sex and gender on bronchoalveolar and vascular compartments from embryonic and neonatal stages through to adolescence, adulthood and elder age
Artificial intelligence and radiomics applications in adrenal lesions: a systematic review
No full textBackground: Adrenal lesions, often incidentally detected, present diagnostic challenges in distinguishing benign from malignant or hormonally active lesions. Conventional imaging (computed tomography/magnetic resonance imaging (CT/MRI)) has limitations, driving interest in artificial intelligence (AI) and radiomics for enhanced accuracy.
Objectives: To systematically evaluate AI and radiomics applications in adrenal lesion characterization, focusing on diagnostic performance, methodologies, and clinical utility.
Design: PRISMA-guided systematic review of studies published up to June 2024.
Data sources and methods: PubMed, Scopus, Web of Science, and Google Scholar were searched using the keywords: adrenal lesions, AI, radiomics, and machine learning. Inclusion followed PICO criteria: patients with indeterminate lesions, AI/radiomics interventions, comparisons to standard diagnostics, and diagnostic accuracy. Two reviewers screened studies, resolving discrepancies via consensus. Eleven retrospective studies (996 patients) met eligibility.
Results: CT-based radiomics (eight studies) achieved a mean AUC of 0.88 (range: 0.84-0.94) in differentiating benign/malignant or functional/non-functional lesions. Top-performing models identified aldosterone-producing adenomas (AUC: 0.99). MRI-based radiomics (three studies) yielded mean AUC: 0.82 (0.72-0.92), with test-set performance declines (e.g., AUC: 0.72) suggesting overfitting. Nuclear medicine (four studies) demonstrated that hybrid 18F-FDG PET/CT models (SUVmax + texture features) achieved an AUC of 0.97 for metastatic versus benign lesions. AI applications extended to intraoperative navigation (AUC: 0.93) and prognostic prediction.
Conclusion: CT-based radiomics outperformed MRI, aligning with guidelines favoring CT for adrenal assessment. AI-enhanced models show promise in refining diagnostics and reducing invasive procedures. However, retrospective designs, small cohorts, and protocol variability limit generalizability. Future work requires multicenter collaboration, standardized protocols, and prospective validation to translate AI/radiomics into clinical practice