Archivio Istituzionale della Ricerca- Università degli Studi di Foggia
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    Studiare con metodo. Sull'intreccio formazione e orientamento

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    Toward Sustainable Fertilization: Biochar and Plant Growth Promoting Bacteria (PGPB) Influence on Sweet Pepper (Capsicuum annuum L.) Development and Production Under Reduced Nitrogen Input

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    Soil amendment with biochar and PGPB represents a promising strategy to reduce dependence on chemical fertilizers. This study aimed to evaluate the potential of biochar and PGPB application, under a reduced nitrogen fertilization, to sustain sweet pepper growth and production, soil chemical and microbiological fertility. Plants were grown in pots under greenhouse on soil un-amended or amended with 2% biochar (B0 and B2), un-inoculated or inoculated with PGPB (P0 and P+) and un-fertilized or fertilized with 50 (half dose) or 100 (full dose) kg N ha−1 (N0, N50 and N100). Plant above- and below-ground biomass development, soil chemical and microbiological properties, and fruit quanti-qualitative traits were assessed during and/or at the end of two periods: from transplanting (T0) to flowering initiation (T1) and from flowering initiation to harvest (T2). Under B2-P+ treatment, N50 fertilized plants exhibited growth similar to N100, with 50% higher height and more than doubled leaf number compared with N0. At T2, the Absolute Growth Rate of plant height increased by 12% under B2 compared with B0, by 45% under P+ compared with T1, while the Absolute Growth Rate of leaf number was 60% higher under B2 compared with T1. Biochar and PGPB resulted in higher N tissue concentrations (+66 and +34% in stem; +16 and +11% in leaves, respectively), root length (+27%) and biomass (+170%), respectively. At soil level, B2 increased carbon and nitrogen contents by 94% and 25% compared with B0; P+ resulted in 12% higher carbon content, compared with P-; half N fertilization favoured microbial growth. N50 fertilized plants showed fruit yield, weight, nitrogen and carbon contents comparable to N100. Biochar and PGPB application with half N dose maintained pepper growth and yield at levels comparable to full N fertilization, while improving soil fertility and exerting a modulatory effect on specific soil bacterial families

    Persone vulnerabili e mediazione penale

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    Automatos bios e l’“utopia” di un mondo senza schiavi nei frammenti della commedia attica

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    Immagini di straordinarie abbuffate ricorrono in una sezione dei Deipnosofisti di Ateneo (VI, 267e-270a), in cui l’erudito di Naucrati, trattando dell’archaios bios, un contesto di particolare benessere assimilabile a quello che nella lingua italiana è riferito al “paese di Cuccagna”, tramanda i frammenti di alcuni commediografi attivi ad Atene nella seconda metà del V sec. a. C. (Cratino, Pluti, fr. 176 K.-A.; Cratete, Bestie, frr. 16-17 K.-A.; Teleclide, Anfizioni, fr. 1 K.-A.; Ferecrate, Minatori, fr. 113 K.-A.; Persiani, fr. 137 K.-A.; Nicofonte, Sirene, fr. 21 K.-A.; Metagene, Turiopersiani, fr. 6 K.-A.). Nella cornice di questi scenari di opulenza si segnalano la proposizione e la variazione di un motivo fondante: l’automatos bios, a cui è associato il vagheggiamento dell’assenza della schiavitù, che, proposta in chiave giocosa, esaurisce i suoi effetti nel breve spazio temporale della rappresentazione teatrale; i comici attici non fecero dell’abolizione della schiavitù il soggetto di una sola commedia; il riconoscimento, anche solo ludico, dell’uguaglianza naturale degli uomini avrebbe comportato la fine della polis, reale o fantastica che fosse: la messa in discussione del lavoro servile non avrebbe potuto dunque far parte del gioco

    Surgical explant of degenerated transcatheter valves: a new type of threat?

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    Objectives: Transcatheter treatment for valvular heart diseases has markedly expanded its indications due to reduced invasiveness and hospitalization time. Despite favourable results, several peculiar and more frequent shortcomings than in surgical-based implantation have been reported. This review aims to provide the currently available information regarding transcatheter valve (THV) implantation and reoperation, focusing on recent available data about surgical management strategies for THV degeneration. Methods: For this narrative review, we searched Medline through the end of March 2025 using medical subject headings and text words supplemented by scanning the bibliographies of recovered articles. The terms "transcatheter valve degeneration", "TAVI degeneration", "surgical treatment", "surgical explant" have been combined using the Boolean operator 'AND'. Results: Currently available literature specifically focuses on aortic THV explant. Peculiar intraoperative (like coronary ostium, aortic wall and annular injury due to THV explant) or short-term postoperative complications related to THV explant have been reported. Thirty-day mortality has been shown to range between 12 to 32.6%, and only short and heterogeneous follow-up periods are available to date. Careful work-up to indicate that valve-in-valve procedure is unfeasible or not appropriate when facing degenerated THV, and a cautious as well as detailed planning of surgical explant have been recently recommended. Conclusions: THV explant due to valve degeneration is rapidly increasing, but, due to its related risk for intra and post-procedural complications, a careful pre-operative evaluation and intraoperative conduct are warranted

    Defining the optimal duration of maintenance mitomycin C in intermediate-risk Ta NMIBC: a multicenter retrospective landmark analysis

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    Purpose: While mitomycin C (MMC) is widely used for intravesical therapy, the optimal maintenance regimen for non-muscle invasive bladder cancer (NMIBC) remains unclear. This study assessed the impact of MMC maintenance on recurrence-free survival (RFS) in patients with intermediate-risk Ta NMIBC and aimed to identify the optimal number of instillations for improved outcomes. Methods: We conducted a retrospective multicenter analysis of patients with Ta NMIBC treated with transurethral resection and adjuvant MMC across 13 Italian centers (2010-2023). Patients were grouped based on MMC maintenance duration: no maintenance, short-term (≤ 6 instillations), and long-term (> 6 instillations). Kaplan-Meier curves, Cox regression, and CART analysis were used to evaluate RFS and high-grade RFS (HG-RFS). Results: Among 292 patients included, maintenance therapy significantly improved 2-year and 3-year RFS compared to no maintenance (78% vs. 55% and 67% vs. 30%, respectively; p < 0.001). CART analysis identified > 6 instillations as the threshold for optimal benefit. Long-term maintenance was associated with a lower risk of recurrence (HR 0.23 vs. no maintenance; HR 0.39 vs. short-term; both p < 0.001). No significant difference in HG-RFS was observed between no maintenance, long-term, and short-term groups. Conclusion: Long-term MMC maintenance (> 6 instillations) significantly prolongs RFS in patients with Ta NMIBC. These findings suggest that extended MMC regimens may improve patients' outcomes and should be considered in clinical practice. Prospective studies are needed to confirm these results and guide evidence-based treatment strategies

    Optimizing target inactivation to treat multidrug-resistant Escherichia coli with NDM and PBP3 mutations: “going the extra mile”

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    A 65-year-old man without identifiable risk factors for multidrug-resistant pathogens was admitted with peritonitis, isolating NDM-producing Escherichia coli from a rectal swab and intraoperative samples. After surgery, ceftazidime-avibactam/aztreonam was administered. Due to poor clinical response, he was switched to imipenem-relebactam/aztreonam, resulting in a successful outcome. Whole-genome sequencing detected blaNDM-5 and blaCMY-148 β-lactamases, PBP3 YRIN insertion, and mutated cirA gene. This case illustrates the importance of considering different mechanisms of resistance when choosing combination therapy

    Il Dottore commercialista nella redazione e attestazione dei Piani industriali: l’analisi strategica come nuovo paradigma e standard?

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    Il presente articolo vuole indagare sugli standard e best practices professionali in tema di piani industriali. L’obiettivo, inoltre, è quello di fornire una visione critica e insieme innovativa per una riforma degli standard in tema di piani industriali, che vada nella direzione del controllo strategico e della verifica ex ante e ex post circa la validità della strategia aziendale, alla base dei dati quantitativi stimati nei piani industriali. In sostanza la domanda da porsi è se gli standard per i piani industriali oggi riescono a verificare l’adeguatezza della strategia d’impresa delineata alla base delle proiezioni quantitative conseguenti, esplicitate nel Piano

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