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    Integrated transcriptomic and immune enzymatic analyses uncover coordinated immunometabolic responses in large yellow croaker (Larimichthys crocea) to Metanophrys sp. infection

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    Metanophrys sp. (Scuticociliatida) has recently emerged as a significant parasitic threat in large yellow croaker (Larimichthys crocea) aquaculture. To elucidate the host response, we conducted an experimental infection followed by an integrated analysis combining immune enzymatic profiling and transcriptome sequencing.Antioxidant and immune enzyme activities, including SOD, CAT, and MDA in the skin, gill, and liver, and LYZ and Na + /K + -ATPase in the skin and gill were monitored from 0 to 72 hours post-infection (hpi). The results revealed tissue-and time-specific significant changes, indicating increased oxidative stress and activation of compensatory antioxidant and mucosal immune defenses. At the resolution phase of infection (72 hpi), dorsal skin tissue was subjected to RNA sequencing (RNA-seq), identifying 6,360 differentially expressed genes (DEGs), including 3,164 upregulated and 2,702 downregulated transcripts. GO and KEGG enrichment analyses revealed strong activation of key immune signaling pathways, such as NOD-like receptor, IL-17, chemokine, and cytokine-cytokine receptor interaction, alongside metabolic reprogramming involving oxidative phosphorylation, glycolysis/gluconeogenesis, and lipid metabolism. Inflammatory mediators associated with IL-17 signaling, including cox2, cxcl8, mmp9 and hsp90, together with chemokine-related effectors such as akt, raf1, and rhoA were significantly upregulated, suggesting strong mucosal inflammation and thrombocyte involvement, functionally analogous to the platelet-activation pathway in mammals. Notably, immunometabolic convergence was evidenced by coupregulation of genes such as il1b, il6, cxcl8, mmp9, pnpla2, and foxo1, reflecting the simultaneous activation of inflammatory and metabolic regulatory programs during host defense. Swiss-Prot annotations confirmed the conserved functional roles of these genes in cytokine signaling, energy mobilization, and tissue protection. qPCR validation of 12 representative genes showed strong concordance with the RNA-seq expression profile (R²=0.98). Together, these findings demonstrate that L. crocea mounts a temporally coordinated immunometabolic response to Metanophrys sp., providing mechanistic insights into mucosal defense and offering candidate biomarkers for targeted disease management in marine aquaculture.publishedVersio

    Expanding Forest Cover Increases the Ecosystem Service Values of Dry Afromontane Forests in Tigray, Ethiopia

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    Author’s accepted manuscript (postprint).This is an Accepted Manuscript of an article published by John Wiley & Sons in Land Degradation and Development on 6/3/2025.Available online: https://doi.org/10.1002/ldr.5564.acceptedVersio

    Literary practices, capital structures and political position-taking: The Norwegian writers during World War II

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    Analyses of writers’ political orientations have typically focused on individual authors’ works and trajectories. Inspired by Bourdieu's field theory and by Sapiro's works on the French literary field, this article demonstrates how the Norwegian writers’ position-takings during WW II were related to their locations in two other sets of structures: the structures in the Norwegian field of literary practices in the 1930s and '40s, and their locations in cultural, economic and social capital hierarchies. Based on data on 308 writers we ask: How did the writers and intellectuals respond to democratic backsliding, loss of cultural autonomy and authoritarianism on the rise? Three main literary oppositions were uncovered by way of MCA: Non-Fiction vs. Fiction, Traditional vs Modern literature and Popular vs. Other literature. These oppositions were structured along hierarchies of personal and inherited cultural capital, and of economic capital. The association between literary and political orientations was clear. Urban, modern-oriented writers with upper-class backgrounds had higher probabilities of partaking in resistance, while more marginal, tradition-oriented writers with a lower-class origin had higher probabilities of supporting the occupation; during WWII, the literary elite thus faced both an external shock and a challenge “from below”. Out of eight literary clusters, five were political: Academics, Modernists, Proletarians, National Romanticists and Vitalists. Nazi-sympathizing or collaborating writers were overrepresented in latter two. But a Class Specific MCA revealed internal divisions among the Nazi-sympathizing or collaborating writers that did not mirror those found in the global space; distinct hierarchies were at work. When analyzing how a given constellation of factors might produce different outcomes across a population, the integration of MCA and CSA therefore offers a promising approach.publishedVersio

    Comparisons of clinical and biomechanical assessments within elite handball players playing with previous, current, and non-symptomatic shoulder pain. What is relevant?

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    Doctoral thesis (PhD) - Nord University, 2025publishedVersio

    How to be a fictionalist about sport: response to Archer and Wojtowicz

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    Effects of wheat and faba bean intercropping on yield, land-use efficiency and economic revenue in semi-arid areas

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    Author’s accepted manuscript (postprint). This is an Accepted Manuscript of an article published by American Society of Agronomy in Agronomy Journal on 27/2/2025, available online: https://doi.org/10.1002/agj2.70031.This is an Accepted Manuscript of an article published by American Society of Agronomy in Agronomy Journal on 27/2/2025.Available online: https://doi.org/10.1002/agj2.70031.acceptedVersio

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