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Occupational exposures of firefighting and prostate cancer risk in the Norwegian Fire Departments Cohort
No full textObjectives Excess incidence of prostate cancer (PC) is frequently observed among firefighters; however, the association with specific occupational exposures of firefighting, as well as the influence of a medical surveillance bias, remains unclear. Our aim was to study PC risk within a firefighter cohort, applying indicators of exposures. Methods We used indicators of various firefighting exposures to examine PC risk among men in the Norwegian Fire Departments Cohort (N=4251). Incident PC cases, including clinical characteristics, were obtained from the Cancer Registry of Norway (1960–2021). Cox regression was used to estimate hazard ratios (HR) by cumulative exposure in tertiles (reference: lowest) for all, aggressive, and indolent PC, with adjustment for age and birth cohort. The cumulative incidence of PC across birth cohorts and diagnostic periods was examined. Results No clear associations emerged for any of the exposure indicators, although we observed an HR of 1.31 [95% confidence interval (CI) 0.63–2.72] for aggressive PC in the highest tertile of fire exposure score and 1.31 (95% CI 0.60–2.89) for indolent PC in the highest tertile of inhalation score. Assessment of cumulative incidence demonstrated a greater number of diagnoses at younger ages after 1990, particularly for indolent and unclassifiable PC. Conclusions We found little support for an association between firefighting exposures and PC risk. However, our study had few cases in analyses by clinical stage. Challenges in studies of firefighters’ PC risk remain, including difficulties in exposure characterization and the unclear magnitude of a medical surveillance bias.Occupational exposures of firefighting and prostate cancer risk in the Norwegian Fire Departments CohortpublishedVersio
Scientific opinion on the tolerable upper intake level for preformed vitamin A and β-carotene
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Salvage Reirradiation for Locally Recurrent Prostate Cancer: Results from a Prospective Study with 7.2 Years of Follow-Up
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Occupational exposures of firefighting and prostate cancer risk in the Norwegian Fire Departments Cohort
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The unique and synergistic effects of social isolation and loneliness on 20-years mortality risks in older men and women
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Effect of the COVID-19 pandemic on mental health visits in primary care: an interrupted time series analysis from nine INTRePID countries
No full textBackground The COVID-19 pandemic impacted mental health disorders, affecting both individuals with pre-existing conditions and those with no prior history. However, there is limited evidence regarding the pandemic's impact on mental health visits to primary care physicians. The International Consortium of Primary Care Big Data Researchers (INTRePID) explored primary care visit trends related to mental health conditions in Argentina, Australia, Canada, China, Norway, Peru, Singapore, Sweden, and the USA. Methods We conducted an interrupted time series analysis in nine countries to examine changes in rates of monthly mental health visits to primary care settings from January 1st, 2018, to December 31st, 2021. Sub-group analysis considered service type (in-person/virtual) and six categories of mental health conditions (anxiety/depression, bipolar/schizophrenia/other psychotic disorders, sleep disorders, dementia, ADHD/eating disorders, and substance use disorder). Findings Mental health visit rates increased after the onset of the pandemic in most countries. In Argentina, Canada, China, Norway, Peru, and Singapore, this increase was immediate ranged from an incidence rate ratio of 1·118 [95% CI 1.053–1.187] to 2.240 [95% CI 2.057–2.439] when comparing the first month of pandemic with the pre-pandemic trend. Increases in the following months varied across countries. Anxiety/depression was the leading reason for mental health visits in most countries. Virtual visits were reported in Australia, Canada, Norway, Peru, Sweden, and the USA, accounting for up to 40% of the total mental health visits. Interpretation Findings suggest an overall increase in mental health visits, driven largely by anxiety/depression. During the COVID-19 pandemic, many of the studied countries adopted virtual care in particular for mental health visits. Primary care plays a crucial role in addressing mental ill-health in times of crisis.publishedVersio
Healthcare workers’ informal uses of mobile phones and other mobile devices to support their work: a qualitative evidence synthesis
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Vaksinasjonsdekning mot covid-19 etter fødeland og underliggende risiko for alvorlig sykdomsforløp
No full textBakgrunn I Norge har det vært høy oppslutning om koronavaksinasjonsprogrammet gjennom pandemien, men i tidligere studier har det blitt observert variasjon etter fødeland. Dersom de uvaksinerte er unge og friske, vil risikoen og konsekvensene for den enkelte og for helsetjenesten være mindre enn dersom de uvaksinerte har underliggende risiko for alvorlig covid-19-sykdom. Målet med studien var å undersøke i hvilken grad vaksinasjonsdekning varierte med fødeland hos personer med og uten underliggende risiko. Materiale og metode Vi brukte beredskapsregisteret Beredt C19 til å knytte vaksinasjonsdekning til demografiske og helsemessige variabler. Med Poisson-regresjon beregnet vi relativ risiko for å være vaksinert for utenlandsfødte sammenlignet med norskfødte, for personer med og uten underliggende risiko for alvorlig covid-19-sykdom, justert for kjønn, alder, utdanningsnivå, husholdningsinntekt og fylke. Resultater Totalt 4 304 349 personer inngikk i studiepopulasjonen, hvorav 768 312 hadde fødeland utenfor Norge. Vaksinasjonsdekningen totalt varierte fra 47 til 94 % mellom fødeland. Variasjonen mellom fødeland var mindre i gruppen med underliggende risiko – fra 63 til 96 %. Forskjellen mellom personer med og uten underliggende risiko var mest uttalt blant personer født i Polen (RR 0,71 og 0,55) og Litauen (RR 0,69 og 0,61). Dette tilsvarte en forskjell i relativ risiko på henholdsvis 0,16 og 0,08 i absolutte tall. Fortolkning Høyere vaksinasjonsdekning mot covid-19 blant personer med underliggende risiko, innebærer at variasjonen mellom fødeland kan ha hatt mindre alvorlige implikasjoner med hensyn til alvorlig forløp og behov for helsetjenester enn tidligere antatt. Hovedfunn Tidligere påvist variasjon i vaksinasjonsdekningen mellom norskfødte og utenlandsfødte var mindre blant personer med underliggende risiko for alvorlig covid-19-sykdom, og de som dermed hadde størst nytte av vaksinen.Vaksinasjonsdekning mot covid-19 etter fødeland og underliggende risiko for alvorlig sykdomsforløppublishedVersio
