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Quadrivalent HPV Vaccine Effectiveness Against Cervical Intraepithelial Lesion Grade 2 or Worse in Norway: A Registry-Based Study of 0.9 Million Norwegian Women
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Effect of polygenic scores of telomere length alleles on telomere length in newborns and parents
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Prediction of clinically significant recurrence after partial nephrectomy. Data from the Cancer Registry of Norway with more than five years of follow-up
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Post-diagnosis dietary factors, supplement use and colorectal cancer prognosis: A Global Cancer Update Programme (CUP Global) systematic literature review and meta-analysis
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The relationship between clinical impairment and blood drug concentration: Comparison between the most prevalent traffic relevant drug groups
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Nationwide study on development and validation of a risk prediction model for CIN3+ and cervical cancer in Estonia
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Post-injury use of opioid analgesics in patients with traumatic injury: A registry-based study
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Multimorbidity patterns and trajectories in young and middle-aged adults: a large-scale population-based cohort study
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Comparative genomics of quinolone-resistant Escherichia coli from broilers and humans in Norway
No full textBackground The usage of fluoroquinolones in Norwegian livestock production is very low, including in broiler production. Historically, quinolone-resistant Escherichia coli (QREC) isolated from Norwegian production animals rarely occur. However, with the introduction of a selective screening method for QREC in the Norwegian monitoring programme for antimicrobial resistance in the veterinary sector in 2014; 89.5% of broiler caecal samples and 70.7% of broiler meat samples were positive. This triggered the concern if there could be possible links between broiler and human reservoirs of QREC. We are addressing this by characterizing genomes of QREC from humans (healthy carriers and patients) and broiler isolates (meat and caecum). Results The most frequent mechanism for quinolone resistance in both broiler and human E. coli isolates were mutations in the chromosomally located gyrA and parC genes, although plasmid mediated quinolone resistance (PMQR) was also identified. There was some relatedness of the isolates within human and broiler groups, but little between these two groups. Further, some overlap was seen for isolates with the same sequence type isolated from broiler and humans, but overall, the SNP distance was high. Conclusion Based on data from this study, QREC from broiler makes a limited contribution to the incidence of QREC in humans in Norway.Comparative genomics of quinolone-resistant Escherichia coli from broilers and humans in NorwaypublishedVersio
