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Non-detriment finding for ringtailed lemur
Get PDFUtførsel av fire levende ringhalelemurer (Lemur catta) avlet i fangenskap fra en dyrehage i Norge til en dyrehage i Danmark vil ikke være til skade for artens bevaringsstatus. Det konkluderer Vitenskapskomiteen for mat og miljø (VKM). Vurderingen ble gjort på oppdrag fra Miljødirektoratet, som er forvaltningsmyndighet for Konvensjonen om internasjonal handel med truede arter av vill flora og fauna, CITES, i Norge. VKM er vitenskapelig myndighet for CITES i Norge, og utarbeider vitenskapelige vurderinger (såkalte ‘non-detriment findings’) i tråd med metodikk publisert av Verdens naturvernunion (IUCN) og CITES. Del denne sideNon-detriment finding for ringtailed lemurpublishedVersio
Practicable strategies parents can apply in their daily routine to successfully implement the 50/50-split-model of paid work, childcare, and housework: a qualitative content analysis
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Relative vaccine effectiveness against COVID-19 hospitalisation in persons aged ≥ 65 years: results from a VEBIS network, Europe, October 2021 to July 2023
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Frequency and patterns of substance-induced psychosis in persons with concurrent mental health and substance use disorders during the COVID-19 pandemic: A Norwegian register-based cohort study.
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Experiences and consequences of remote schooling during the Covid-19 pandemic for children and youth in the Nordic countries: a scoping review
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Can revenue collection for public funding in health care be progressive? An assessment of 29 Countries
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Post-diagnosis adiposity and colorectal cancer prognosis: A Global Cancer Update Programme (CUP Global) systematic literature review and meta-analysis
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Improving alcohol and substance use screening in school-age children: translation, adaptation and psychometric evaluation of the CRAFFT tool for Lumasaaba, Uganda
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Digital Food Frequency Questionnaire Assessing Adherence to the Norwegian Food-Based Dietary Guidelines and Other National Lifestyle Recommendations: Instrument Validation Study
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Genetic associations with psychosis and affective disturbance in Alzheimer's disease
Get PDFIntroduction: Individuals with Alzheimer's disease (AD) commonly experience neuropsychiatric symptoms of psychosis (AD+P) and/or affective disturbance (depression, anxiety, and/or irritability, AD+A). This study's goal was to identify the genetic architecture of AD+P and AD+A, as well as their genetically correlated phenotypes. Methods: Genome-wide association meta-analysis of 9988 AD participants from six source studies with participants characterized for AD+P AD+A, and a joint phenotype (AD+A+P). Results: AD+P and AD+A were genetically correlated. However, AD+P and AD+A diverged in their genetic correlations with psychiatric phenotypes in individuals without AD. AD+P was negatively genetically correlated with bipolar disorder and positively with depressive symptoms. AD+A was positively correlated with anxiety disorder and more strongly correlated than AD+P with depressive symptoms. AD+P and AD+A+P had significant estimated heritability, whereas AD+A did not. Examination of the loci most strongly associated with the three phenotypes revealed overlapping and unique associations. Discussion: AD+P, AD+A, and AD+A+P have both shared and divergent genetic associations pointing to the importance of incorporating genetic insights into future treatment development. Highlights: It has long been known that psychotic and affective symptoms are often comorbid in individuals diagnosed with Alzheimer's disease. Here we examined for the first time the genetic architecture underlying this clinical observation, determining that psychotic and affective phenotypes in Alzheimer's disease are genetically correlated.Nevertheless, psychotic and affective phenotypes in Alzheimer's disease diverged in their genetic correlations with psychiatric phenotypes assessed in individuals without Alzheimer's disease. Psychosis in Alzheimer's disease was negatively genetically correlated with bipolar disorder and positively with depressive symptoms, whereas the affective phenotypes in Alzheimer's disease were positively correlated with anxiety disorder and more strongly correlated than psychosis with depressive symptoms.Psychosis in Alzheimer's disease, and the joint psychotic and affective phenotype, had significant estimated heritability, whereas the affective in AD did not.Examination of the loci most strongly associated with the psychotic, affective, or joint phenotypes revealed overlapping and unique associations. Keywords: Alzheimer's disease; affective disturbance; genome‐wide association; heritability; psychosis. © 2024 The Authors. Alzheimer's & Dementia: Translational Research & Clinical Interventions published by Wiley Periodicals LLC on behalf of Alzheimer's Association.publishedVersio