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Factors Related to Psychological Distress of Multiparous Women in the First Trimester: A Cross-Sectional Study
No full text[[abstract]]Background: The birth rate in Taiwan has declined rapidly; thus, encouraging women to give birth is an important issue in the country. Pregnant women may experience psychological distress, which may negatively impact the health of children and mothers. Prenatal psychological distress is more common in multiparous women than in primiparous women. In addition, compared with that in the second and third trimesters, psychological distress in the first trimester is relatively high. Understanding psychological distress and the associated factors for multiparous women in the first trimester is important to providing early interventions and preventing subsequent maternal and child health problems.
Purpose: This study was designed to examine the important predictive factors related to depression, anxiety, and stress among Taiwanese multiparous women in the first trimester.
Methods: A cross-sectional design was used. In all, 216 multiparous women at 16 weeks of pregnancy were recruited from three hospitals in Taiwan. Self-reported questionnaires were used to gather data on demographic characteristics, the parenting stress of motherhood, spousal support, and psychological distress. A multiple logistic regression analysis was conducted to examine the factors associated with psychological distress.
Results: The prevalence of depression, anxiety, and stress in multiparous women was found to be 31.9%, 42.6%, and 11.1%, respectively. The multiple logistic regression analysis indicated that the stress related to parent-child interaction was a significant predictor of depression and anxiety, the stress related to child-rearing was a significant predictor of anxiety, and low spousal instrumental support was a significant predictor of stress. The model respectively explained 30%, 27%, and 23% of the variance in depression, anxiety, and stress.
Conclusions/implications for practice: Reducing the stress related to parent-child interaction and child-rearing and encouraging spousal instrumental support should be considered during prenatal care when designing interventions to reduce the psychological distress of multiparous women in their first trimester
Ursolic acid silences CYP19A1/Aromatase to suppress gastric cancer growth
No full text[[abstract]]Introduction: Gastric cancer (GCa) is a malignancy with few effective treatments. Ursolic acid (UA), a bioactive triterpenoid enriched in Hedyotis diffusa Willd, known to suppress GCa without identified target. CYP19A1 (cytochrome P450 family 19A1; also known as aromatase, Ar) was correlated to GCa prognosis. Relatedly, Ar silencers, which halt the expression of Ar exhibited anti-GCa effects in experimental models, are currently being investigated.
Method: The docking simulation score of UA was compared with Ar inhibitors, e.g., letrozole, exemestane, in Ar protein crystallization. Hedyotis diffusa Willd ethanol extract, UA, or 5-fluracil were applied onto AGS, SC-M1, MKN45 GCa cells for cancer inhibition tests. Immunoblot for measuring gene expressions upon drug treatments, or gene knockdown/overexpression. Treatments were also applied in a MKN45 implantation tumor model. A web-based GCa cohort for Ar expression association with prognosis was performed.
Result: The ethanol extracts of Hedyotis diffusa Willd, enrich with UA, exhibited cytotoxic activity against GCa cells. Molecular docking simulations with the 3D Ar structure revealed an excellent fitting score for UA. UA increase cytotoxic, and suppressed colony, in addition to its Ar silencing capacity. Moreover, UA synergistically facilitated 5-FU, (a standard GCa treatment) regimen in vitro. Consistent with those results, adding estradiol did not reverse the cancer-suppressing effects of UA, which confirmed UA acts as an Ar silencer. Furthermore, UA exhibited tumor-suppressing index (TSI) score of 90% over a 6-week treatment term when used for single dosing in xenograft tumor model. In the clinical setting, Ar expression was found to be higher in GCa tumors than normal parental tissue from the TCGA (The Cancer Genome Atlas) cohort, while high Ar expression associated with poor prognosis. Together, the results indicate UA could be used to treat GCa by silencing Ar expression in GCa. Hedyotis diffusa Willd ethanol extract could be an functional food supplements
Women's trajectories of postpartum depression and social support: A repeated-measures study with implications for evidence-based practice
No full text[[abstract]]Background: Postpartum depression is one of the most common psychological disorders of women after childbirth. Despite the importance of social support as an influencing factor, there have been few studies on the trends and characteristics of social support as it relates to postpartum depression.
Aims: To explore the trends in postpartum depression and social support, to cross-analyze the correlation between the postpartum depression trajectory and the social support trajectory, and to investigate predictors of changes in postpartum depression trajectories.
Methods: A prospective repeated-measure study and convenience sampling were used to recruit 230 women at 1, 3, and 6 months after childbirth. Structured questionnaires were used for data collection. Trajectory analysis was used to explore the trajectories of postpartum depression and social support during the 6 months after childbirth, and polynomial logistic regression was used to explore predictors of the trajectory of postpartum depression.
Results: Postpartum depression was at its most serious in the third month after childbirth, showing patterns of low-risk, moderate-risk, and high-risk trajectories. Social support also showed low, moderate, and high patterns, and the trajectory of postpartum depression was significantly related to the trajectory of social support. The predictors of moderate-risk and high-risk postpartum depression were also found in this study.
Linking evidence to action: Postpartum mental health education and online learning systems should be used to increase social support for women after childbirth and reduce the incidence of postpartum depression
嚴重特殊傳染性肺炎：新冠肺炎之居家照護
No full text[[abstract]]新冠肺炎已造成全球大流行，大量的病患不但考驗醫療體系的量能，也造成醫護人員沉重的負擔。新冠肺炎無症狀或輕症患者大多可採居家照護方式進行居家隔離，不需要到醫院治療。本文利用文獻查證說明新冠肺炎疾病特性、居家照護評估、照顧者及患者在居家環境上的準備、患者自我照顧注意事項，以期無症狀或輕症患者可於家中進行適當的自我隔離照護，對減少醫療量能負荷有所幫助。[[abstract]]Coronavirus disease 2019 (COVID-19) has become a global pandemic. High volumes of COVID-20 patients have not only tested the capacity of the medical system, but have placed a heavy burden on medical and nursing professionals as well. Most patients with as 堝??????? ? 攁愓? ? ? ? ? ? ?? ???耀罈翹 ? ???螈螇螇???????????膗????? ??隗?彰? ?成????? ?? ?? ?? ? ? ?? ? ?? ?? ? ?? ? ? ?? ?? ?? ? 齰? ??? ?? ?? ?? ? ?? ? ? ! " ? ? ?? ?? ? ? ? ??楩? ? ?? ?? ??祔? ???? 颲??????? ? ? ? ? ??膗????? ? 攁愓? ? ? ? ? ? ?? ???耀罈翹 輒考螈螇??梲????????????????? ?????? ?成? ??? ???考?? ?? ? ????? ? ???考 ?? ? ???
Comparative effects of cannabinoid CB1 receptor agonist and antagonist on timing impulsivity induced by d-amphetamine in a differential reinforcement of low-rate response task in male rat.
No full text[[abstract]]Rationale: In human beings and experimental animals, maladaptive impulsivity is manifested by the acute injection of psychostimulants, such as amphetamine. Cannabinoid CB1 receptors have been implicated in the regulation of stimulant-induced impulsive action, but the role of CB1 receptors in timing-related impulsive action by amphetamine remains unknown.
Methods: Male rats were used in evaluating the effects of CB1 receptor antagonist and agonist (SR141716A and WIN55,212-2, respectively) systemically administered individually and combined with d-amphetamine on a differential reinforcement of low-rate response (DRL) task, an operant behavioral test of timing and behavioral inhibition characterized as a type of timing impulsive action.
Results: A distinct pattern of DRL behavioral changes was produced by acute d-amphetamine (0, 0.5, 1.0, and 1.5 mg/kg) treatment in a dose-dependent fashion, whereas no significant dose effect was detected for acute SR141716A (0, 0.3, 1, and 3 mg/kg) or WIN55,212-2 (0, 0.5, 1, and 2 mg/kg) treatment. Furthermore, DRL behavior altered by 1.5 mg/kg d-amphetamine was reversed by a noneffective dose of SR141716A (3 mg/kg) pretreatment. The minimally influenced DRL behavior by 0.5 mg/kg d-amphetamine was affected by pretreatment with a noneffective dose of WIN55,212-2 (1 mg/kg).
Conclusion: These findings reveal that the activation and blockade of CB1 receptors can differentially modulate the timing impulsive action of DRL behavior induced by acute amphetamine treatment. Characterizing how CB1 receptors modulate impulsive behavior will deepen our understanding of the cannabinoid psychopharmacology of impulsivity and may be helpful in developing an optimal pharmacotherapy for reducing maladaptive impulsivity in patients with some psychiatric disorders
Prostate Cancer after Percutaneous Arterial Embolization of the Prostate: A Case Report
No full text[[abstract]]We report a patient with prostate cancer found 2 years after percutaneous arterial embolization (PAE) of the prostate with a rapid increase in prostate specific antigen (PSA) 3 months later, even though the initial result was low. He did not consult a urologist during or after PAE until acute urinary retention developed. The clinical stage was cT2cN1M1b with Gleason grade 5 + 5 = 10. An increase in PSA a short interval after PAE may suggest the presence of prostate cancer. We suggest that patients undergoing PAE should consult a urologist, and that PSA levels should be checked every 3 months in the first year after PSA
行動美術館概念運用於幼兒園美感教育之實證研究-以水墨藝術為例
No full text[[abstract]]當美術館走入幼兒園會發生什麼有趣好玩的事呢？本文製作出兩組由主題名稱物件及10項展示教材組成的「水墨藝術行動美術館」，將其設置在兩個北部私立幼兒園大班教室為期四週，透過訪談及觀察記錄，採集25位幼兒、兩位教師及筆者的參與情形，再將蒐得資料加以比對、分析與歸納。研究結果發現行動美術館在美感教育的運用成效：一則，幼兒教師增進了對該水墨藝術行動美術館的認識，並肯定它運用在幼兒師生教與學的行動經驗；另則，幼兒的學習表現包括：在水墨藝術情境中參與體驗，增進美感的探索體驗與感受覺察；表現對水墨創作主動正向的情意與態度，並嘗試以多元技法表現與創作；以及欣賞水墨作品的內容、視覺元素並表達個人想法，提升認知與理解美感的能力。[[abstract]]What happens when an art museum meets a preschool classroom? Two curriculum models for a Mobile Art Museum of Ink Art were created, composed of theme-related objects and ten teaching materials for the exhibition. Then the mobile art museums were set up in the kindergarten classrooms of two private preschools in northern Taiwan for four weeks. Interviews, observation, and records were used to collect information on the participation and situation of 25 children, two teachers, and the researcher. The collected data was used for comparison, analysis, and classification. The resulting study outcomes were: First, the teachers felt that the Mobile Art Museum exceeded their expectations. They were able to become more familiar with it thanks to its location in the classroom, and their experience affirmed its teaching and learning value. In addition, the young children's learning performance includes: They became immersed in and participated in the scenarios presented by the ink art, which enhanced their aesthetic exploration experience and perception; they showed a proactive attitude towards producing ink artworks and attempted to express and create using a variety of methods; and they appreciated the content and visual elements of the ink artworks and expressed their personal thoughts, which improved their ability to recognize and understand aesthetic
How to improve the problem of hotel manpower shortage in the COVID?19 epidemic environment? Exploring the efectiveness of the hotel practice training system
No full text[[abstract]]This study aimed to examine the role of effective employee training in the sustainable growth and corporate social responsibility of hotels during the postpandemic period. An initial respondent pool was selected using purposive sampling, and 280 questionnaires were finally obtained by snowball sampling from September 2019 to February 2020. The sample was analyzed using basic statistical tests, the Pearson correlation coefficient, and multivariate regression. We then interpreted the sample data through consultation with scholars and practitioners in hotel management. Finally, the data were analyzed using multivariate verification. The results indicated that China Binhai Hotel could not foster consistent employee enthusiasm and fulfill its corporate social responsibilities during the postpandemic period due to deficiencies in its human resources training, employee benefit, job rotation, and incentive systems. We suggest for hotels to promote corporate culture, improve the system of promotion, increase employee benefits, and adjust the workplace environment and equipment provided to employees. These will improve employee attitudes toward hotel management, improve work efficiency, increase retention, and solve the problem of personnel shortage during the postpandemic period